Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An adjustable bottle support for a pump used in medical procedures comprises first and second support members mounted on an attachment member which is attachable to a pump body. The second support member is pivotally mounted on the attachment member for rotation between a first position in which in which the first and second support members are aligned and level with one another and a second position in which the second support member is tilted and slopes upwardly in a direction away from the first support member.

Abstract: An authoring platform for authoring a client workflow includes an arrangement of shapes representing steps and connections representing relationships between the steps. Online content retrieved from an online resource may be associated with steps of the client workflow. An authoring service receives the client workflow from the client interface via a network and directs a graph database to store a database workflow corresponding to the client workflow. A search platform is provided for creating and searching workflows using a tag database taxonomy. An author creates a workflow wherein a tag is linked to a workflow item. The workflow is stored as a database workflow and a node in the database workflow representing the workflow item is linked to a node in the database taxonomy representing the tag. Multiple workflows are created in a similar manner to link the workflows to the database taxonomy to provide efficient searching of the workflows.

Abstract: A cable management device comprises first and second arms and a base together defining an enclosure for one or more cables. The device includes an attachment and spacer device and a stabilizing clip to releasably attach the device to a support element and to space the enclosures of adjacent devices from one another.

Abstract: An authoring platform for authoring a client workflow includes an arrangement of shapes representing steps and connections representing relationships between the steps. Online content retrieved from an online resource may be associated with steps of the client workflow. An authoring service receives the client workflow from the client interface via a network and directs a graph database to store a database workflow corresponding to the client workflow. A search platform is provided for creating and searching workflows using a tag database taxonomy. An author creates a workflow wherein a tag is linked to a workflow item. The workflow is stored as a database workflow and a node in the database workflow representing the workflow item is linked to a node in the database taxonomy representing the tag. Multiple workflows are created in a similar manner to link the workflows to the database taxonomy to provide efficient searching of the workflows.

Abstract: An adjustable bottle support for a pump used in medical procedures comprises first and second support members mounted on an attachment member which is attachable to a pump body. The second support member is pivotally mounted on the attachment member for rotation between a first position in which in which the first and second support members are aligned and level with one another and a second position in which the second support member is tilted and slopes upwardly in a direction away from the first support member.

Abstract: An adjustable bottle support for a pump used in medical procedures comprises first and second support members pivotally connected together. The first and second support members can be moved between a first position in which they are aligned and level, and a second position in which the second support member is tilted relative to the first support member, to enable the support to hold different configurations of bottle.

Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.

Abstract: A cable management device comprises first and second arms and a base together defining an enclosure for one or more cables. The device includes an attachment and spacer device and a stabilizing clip to releasably attach the device to a support element and to space the enclosures of adjacent devices from one another.

Abstract: A cap for a container holding a liquid for medical use comprises a lid portion and an aperture for receiving a tube. The aperture comprises a slot with first and second ends. The width of the slot is smaller than the length between the first and second ends and the slot tapers from the first end towards the second end. Preferably, a gripping feature such as a protruding rim around the perimeter of the aperture is provided to engage the surface of a tube passing through the aperture.

Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.

Abstract: A filtration unit for purifying or treating fluid that includes one or more membrane units having a permeate section. The permeate section of the membrane units is fed fluid that passes through a sealing insert having a fluid inlet and a passage that discharges in fluid communication with the permeate section. The sealing insert is arranged in a support frame of the membrane unit to form a fluid channel for delivering fluid through the insert and along an outer perimeter surface that maintains performance of the membrane unit during operation.

Abstract: A tank is disclosed as having a tub therein that divides the volume of the tank into an anoxic chamber inside the tub and an equalization chamber outside of the tub. The anoxic chamber anoxically treats wastewater while the equalization chamber equalizes fluctuations in wastewater influent as well as provides a holding space for wastewater if power to the tank is cut off. The tank can be part of a system for treating wastewater, such as one with an anaerobic tank having an anaerobic chamber for anaerobically treating wastewater, an aerobic/filtration tank having a filtration sub-tank therein that divides the volume of the tank into a filtration chamber inside the sub-tank and an aerobic chamber outside of the sub-tank. The aerobic chamber can aerobically treat wastewater while the filtration chamber has a membrane unit for filtering wastewater.

Abstract: A wastewater treatment system includes a biological reactor having anaerobic, anoxic, and aerobic chambers. A lift station including a pump is operatively connected to a tertiary filter downstream of the biological reactor. The lift station receives biologically treated liquid from the tertiary filter and pumps the liquid from the lift station. A filtration subsystem is operatively connected to the lift station. The filtration subsystem receives and filters the liquid pumped by the lift station. The filtration subsystem includes a preliminary filter and a salt-rejecting membrane filter having a recycle conduit operatively connected to recirculate salt-rejecting membrane filter, thereby forming a salt concentration loop between biological reactor and the salt-rejecting membrane filter. A post-filtration subsystem is operatively connected to receive salt-rejecting membrane filter permeate, and includes an adsorbent and oxidation system.

Abstract: A filtration unit for purifying or treating fluid that includes one or more membrane units having a permeate section. The permeate section of the membrane units is fed fluid that passes through a sealing insert having a fluid inlet and a passage that discharges in fluid communication with the permeate section. The sealing insert is arranged in a support frame of the membrane unit to form a fluid channel for delivering fluid through the insert and along an outer perimeter surface that maintains performance of the membrane unit during operation.

Abstract: An authoring platform for authoring a client workflow includes an arrangement of shapes representing steps and connections representing relationships between the steps. Online content retrieved from an online resource may be associated with steps of the client workflow. An authoring service receives the client workflow from the client interface via a network and directs a graph database to store a database workflow corresponding to the client workflow. A search platform is provided for creating and searching workflows using a tag database taxonomy. An author creates a workflow wherein a tag is linked to a workflow item. The workflow is stored as a database workflow and a node in the database workflow representing the workflow item is linked to a node in the database taxonomy representing the tag. Multiple workflows are created in a similar manner to link the workflows to the database taxonomy to provide efficient searching of the workflows.

Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.