Abstract: A method and apparatus for tracking and responding to mobile events in a relationship management system is described. The method may include detecting a mobile event associated with a user of a relationship management system. Furthermore, the method may include analyzing the mobile event to determine at least one relationship management process associated with the user for which the mobile event is related. The method may also include generating one or more relationship management system notifications for transmission to the mobile device of the user prior to initiation of the mobile event, and generating one or more relationship management suggestions or relationship management system notifications for transmission to the mobile device of the user after a termination of the mobile event.

Abstract: A wellbore system comprising an autofill and circulation assembly comprising a housing defining a flowbore and comprising a first port and a second port, and a first sleeve slidable within the housing from a first position to a second position and from the second position to a third position, when the first sleeve is in the first position, the assembly allows fluid communication from an exterior of the housing to the flowbore via the first port and does not allow fluid communication from the flowbore to the exterior of the housing via the first port, when the first sleeve is in the second position, the assembly allows bidirectional fluid communication between the exterior of the housing and the flowbore via the second port, and, when the first sleeve is in the third position, the assembly disallows fluid communication between the exterior of the housing and the flowbore.

Abstract: A method and apparatus for communication sharing in a relationship management system is described. The method may include obtaining an electronic communication by a relationship management system and extracting identification data from the electronic communication. Furthermore, the method may include locating a collaborator and a relationship in the extracted identification data, wherein the collaborator and the relationship are participants in a relationship management process. The method may also include determining when the collaborator and the relationship are both members in a communications sharing list that is associated with the relationship management process, and distributing data associated with the electronic communication to collaborator members in the communications sharing list.

Abstract: A method and apparatus for tracking and responding to mobile events in a relationship management system is described. The method may include detecting a mobile event associated with a user of a relationship management system. Furthermore, the method may include analyzing the mobile event to determine at least one relationship management process associated with the user for which the mobile event is related. The method may also include generating one or more relationship management system notifications for transmission to the mobile device of the user prior to initiation of the mobile event, and generating one or more relationship management suggestions or relationship management system notifications for transmission to the mobile device of the user after a termination of the mobile event.

Abstract: Disclosed is reclosable sleeve assembly including a housing defining one or more flow ports that provide fluid communication between a wellbore annulus and an interior of the housing, an outer sleeve arranged within the housing and movable between a closed position, where the outer sleeve occludes the one or more flow ports, and an open position, where the one or more flow ports are exposed, and an inner sleeve concentrically arranged within the outer sleeve and defining a plurality of flow slots, the inner sleeve being movable between an open position and a closed position where, when in the open position, the plurality of flow slots are axially aligned with the one or more flow ports.

Abstract: A method and apparatus for the automatic suggestion generation in a relationship management system is described. The method may include obtaining an electronic communication associated with one or more users of a relationship management system, where the communication is part of a series of communications in a process managed by the relationship management system. Furthermore, the method may include analyzing content of the electronic communication to determine a suggested future action within the process managed by the relationship management system. The method may also include generating a suggestion by the relationship management system to notify at least one user of the suggested future action, and storing the generated suggestion within a database coupled with the relationship management system.

Abstract: A method and apparatus for the automatic creation of a relationship management system is described. The method may include receiving a request from a user to create a relationship management system, and receiving specification of one or more electronic communication systems and user access credentials that provide access to each of the corresponding accounts. Furthermore, the method may include obtaining past electronic communications using the received user access credentials and analyzing the past electronic communications to extract contact data. The method may also include creating the relationship management system for the user and adding the contact data as contacts associated with the user in the created relationship management system.

Abstract: The exchange-driven electronic market system disclosed herein allows increasing volume and efficiency of transactions between buyers and sellers in a marketplace. An implementation of the electronic market system includes a method comprising receiving a plurality of sale offers, each sale offer including required revenue values required volume values for a product, determining an offered market price based on the plurality of sale offers, displaying the offered market price to a plurality of buyers, receiving from the plurality of buyers a plurality of conditional offers for purchases (COPs), and completing a plurality of sales transactions, if the combination of one or more of the plurality of COPs meets the combination of one or more of the required revenue values.

Abstract: Disclosed are systems and methods for mechanically reclosing a hydraulically actuated sliding side door of a sleeve assembly. One sleeve assembly includes a housing defining one or more flow ports, a sliding sleeve arranged within the housing and movable between a closed position and an open position and back to the closed position, wherein, when in the closed position, the outer sleeve occludes the one or more flow ports, and, when in the open position, the one or more flow ports are exposed. A piston is movably arranged within a piston bore defined in the housing, and a locking mechanism is arranged within the piston bore and configured to engage the piston with the sliding sleeve, thereby allowing the piston to move the sliding sleeve to the open position.

Abstract: There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1 or SEQ ID NO:12, wherein the polypeptide binds to the extracellular domain ECD of HER-2 at an affinity of at least 108, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO:2 or SEQ ID NO:13, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier. Also disclosed are prognostic and diagnostic assays.

Abstract: There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1 or SEQ ID NO:12, wherein the polypeptide binds to the extracellular domain ECD of HER-2 at an affinity of at least 108, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO:2 or SEQ ID NO:13, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier. Also disclosed are prognostic and diagnostic assays.

Abstract: There is disclosed a a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO:1, wherein the polypeptide binds to the extracellular domain ECD of HER-2 with an affinity binding constant of at least 108 M?1, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO:2, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier. Also disclosed are prognostic and diagnostic assays.

Abstract: There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an iso lated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1, wherein the polypeptide binds to the extracellular domain ECD of HER-2 with an affinity binding constant of at least 108 M?1, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO. 2, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier. Also disclosed are prognostic and diagnostic assays.

Abstract: There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1 or SEQ ID NO:12, wherein the polypeptide binds to the extracellular domain ECD of HER-2 at an affinity of at least 108, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO:2 or SEQ ID NO:13, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier. Also disclosed are prognostic and diagnostic assays.