Abstract: The present invention concerns a method of degrading target proteins, by forming fusion proteins which comprise hole-modified mutant BET bromodomains conjugated to the target protein and using a degrader compound to initiate protein degradation.

Abstract: A system for basing drones is described. A network of geographically diverse hangars provides storage and charging locations as well as backhaul communications infrastructure and video monitoring. As drones are needed, a central command point tasks an available drone, which may or may not already be located in proximity to a target. If additional drones are needed, drones can be flown to the area of interest and continuous coverage provided by charging drones while an active drone is conducting the mission, then rotating charged drones into the active mission. Structures for the hangars, the overall system, and methods of operation are described.

Abstract: Instrument free “plasticware” is provided that enables multi-step molecular reactions in a diagnostics context. A hollow plunger that is movable within a surrounding tube defines a reaction chamber inside the plunger. By moving the plunger to different positions in the tube, a sample can be collected, then the sample can be washed, and finally the reaction chamber can be sealed to perform diagnostic reactions on the sample. The juxtaposition of large sample collection/washing volume with small reaction volume allows one to conduct a wide range of diagnostic assays including a LAMP (Loop mediated isothermal amplification) based saliva test in a small, portable self-contained device. Applications include Molecular diagnostics for health applications (including COVID19 test), Environmental Monitoring, Disease surveillance, and Veterinary health.

Abstract: A system for controlling a multi-zone resistive heater. The system includes a first zone of the multi-zone resistive heater formed from a material having a negative temperature coefficient of resistivity (TCR) and configured to receive a first power to generate thermal energy. The system further includes a second zone of the multi-zone resistive heater formed from the material having the negative TCR, separated from the first zone by a gap, and configured to receive a second power to generate the thermal energy.

Abstract: A system for basing drones is described. A network of geographically diverse hangars provides storage and charging locations as well as backhaul communications infrastructure and video monitoring. As drones are needed, a central command point tasks an available drone, which may or may not already be located in proximity to a target. If additional drones are needed, drones can be flown to the area of interest and continuous coverage provided by charging drones while an active drone is conducting the mission, then rotating charged drones into the active mission. Structures for the hangars, the overall system, and methods of operation are described.

Abstract: A system for basing drones is described. A network of geographically diverse hangars provides storage and charging locations as well as backhaul communications infrastructure and video monitoring. As drones are needed, a central command point tasks an available drone, which may or may not already be located in proximity to a target. If additional drones are needed, drones can be flown to the area of interest and continuous coverage provided by charging drones while an active drone is conducting the mission, then rotating charged drones into the active mission. Structures for the hangars, the overall system, and methods of operation are described.

Abstract: A system for heating an aircraft surface having a thermally disadvantaged zone includes a carbon nano-tube (CNT) sheet heating element having a power inlet configured to receive power from an external electrical power source and provide it to the CNT sheet heating element that extends across the thermally disadvantaged zone. The CNT sheet heating element is configured and arranged such upon application of power from the external electrical power source to the CNT sheet heating element, the CNT sheet heating element produces a first heat output in a first zone and a second heat output in the thermally disadvantaged zone with the second heat output being greater than the first heat output.

Abstract: A heating element and conductive element system may include a heater conductive element and a heating element. The heater conductive element and the heating element may be integral components. The heater conductive element and the heating element may be discrete components. The heater conductive element may be configured for enhanced mechanical fatigue compared to typical conductive element.

Abstract: A heating element and conductive element system may include a heater conductive element and a heating element. The heater conductive element and the heating element may be integral components. The heater conductive element and the heating element may be discrete components. The heater conductive element may be configured for enhanced mechanical fatigue compared to typical conductive element.

Abstract: Instrument free “plasticware” is provided that enables multi-step molecular reactions in a diagnostics context. A hollow plunger that is movable within a surrounding tube defines a reaction chamber inside the plunger. By moving the plunger to different positions in the tube, a sample can be collected, then the sample can be washed, and finally the reaction chamber can be sealed to perform diagnostic reactions on the sample. The juxtaposition of large sample collection/washing volume with small reaction volume allows one to conduct a wide range of diagnostic assays including a LAMP (Loop mediated isothermal amplification) based saliva test in a small, portable self-contained device. Applications include Molecular diagnostics for health applications (including COVID19 test), Environmental Monitoring, Disease surveillance, and Veterinary health.

Abstract: A system for controlling a multi-zone resistive heater. The system includes a first zone of the multi-zone resistive heater formed from a material having a negative temperature coefficient of resistivity (TCR) and configured to receive a first power to generate thermal energy. The system further includes a second zone of the multi-zone resistive heater formed from the material having the negative TCR, separated from the first zone by a gap, and configured to receive a second power to generate the thermal energy.

Abstract: An additively manufactured heating element is printed on a flexible substrate and attached to an aircraft component having a complex geometric surface. The heating element is made of a plurality of layers of a conductive ink, which is electrically connected to a controller through one or more leads.

Abstract: A heating element and conductive element system may include a heater conductive element and a heating element. The heater conductive element and the heating element may be integral components. The heater conductive element and the heating element may be discrete components. The heater conductive element may be configured for enhanced mechanical fatigue compared to typical conductive element.

Abstract: Notification of an event related to a performance degradation in a network node of a plurality of network nodes in a network is received. The notification is forwarded to a client device. Cache priming is performed based, at least in part, on a network graph that defines connectivity among at least some of the plurality of network nodes. Cache priming includes determining a set of impacted network nodes of the plurality of network nodes that is impacted by the performance degradation based on the connectivity defined by the network graph. Cache priming includes reducing the set of impacted network nodes to a subset of the impacted network nodes. Cache priming also includes retrieving from a persistent data storage device, data defining the subset of the impacted network nodes and storing the data defining the subset of the impacted network nodes in a memory.

Abstract: An additively manufactured heating element is printed on a flexible substrate and attached to an aircraft component having a complex geometric surface. The heating element is made of a plurality of layers of a conductive ink, which is electrically connected to a controller through one or more leads.

Abstract: Methods and systems for monitoring containerized applications are disclosed herein. In one aspect, a containerized application that includes application program instructions and application runtime environment components is installed within an application server. An application manager determines an operational configuration of the containerized application within the application server. The application manager determines a monitor container image based, at least in part, on the determined operational configuration and an application container image of the containerized application. The application manager installs the monitor container image as a containerized monitor application that includes monitor program instructions and monitor runtime environment components that operate as a distinct execution unit managed by the same virtualization engine and the operating system kernel that manage runtime processes of the containerized application.

Abstract: A data processing apparatus contains branch prediction circuitry including a micro branch target buffer, a full branch target buffer and a global history buffer. The branch target buffer entries contain history data which indicates whether or not a number of the following blocks of program instructions, subsequent to and sequential to a block of program instruction identified by that branch target buffer entry containing a branch instruction, do themselves contain any branch instructions. If the history data indicates that the following blocks of program instructions do not contain branches, then the operation of the branch prediction circuitry is suppressed for these following blocks of program instructions so as to save energy.

Abstract: A cache hierarchy and a method of operating the cache hierarchy are disclosed. The cache hierarchy comprises a first cache level comprising an instruction cache, and predecoding circuitry to perform a predecoding operation on instructions having a first encoding format retrieved from memory to generate predecoded instructions having a second encoding format for storage in the instruction cache. The cache hierarchy further comprises a second cache level comprising a cache and the first cache level instruction cache comprises cache control circuitry to control an eviction procedure for the instruction cache in which a predecoded instruction having the second encoding format which is evicted from the instruction cache is stored at the second cache level in the second encoding format. This enables the latency and power cost of the predecoding operation to be avoided when the predecoded instruction is then retrieved from the second cache level for storage in the first level instruction cache again.

Abstract: A tool holder. The tool holder is mounted to a platform (9) and comprises a plurality of legs (1) extending from respective positions on the platform (9) for connecting the platform (9) to respective positions on the workpiece. Each leg (1) has a first joint system (8a) at its platform end allowing each leg (1) to pivot relative to the platform (9). Each first joint system (8a) has an actuator arrangement (34) having a first operating mode in which the actuator arrangement (34) is configured to apply a load to move the respective leg (1), and a second operating mode in which the actuator arrangement (34) is configured to allow free movement of the respective leg (1).

Abstract: An apparatus comprises processing circuitry, an instruction cache, decoding circuitry to decode program instructions fetched from the cache to generate macro-operations to be processed by the processing circuitry, and predecoding circuitry to perform a predecoding operation on a block of program instructions fetched from a data store to generate predecode information to be stored to the cache with the block of instructions. In one example the predecoding operation comprises generating information on how many macro-operations are to generated by the decoding circuitry for a group of one or more program instructions. In another example the predecoding operation comprises generating information indicating whether at least one of a given subset of program instructions within the prefetched block is a branch instruction.