Patents by Inventor Adam R. Renslo

Adam R. Renslo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CASPASE 6 INHIBITORS AND USES THEREOF
    Publication number: 20230202974
    Abstract: Disclosed herein, inter alia, are compounds and methods for inhibiting Caspase 6 and the treatment of diseases, pharmaceutical composition including a compound as described herein and a pharmaceutically acceptable excipient and methods of inhibiting human Caspase 6 protein activity, the method including: contacting the human Caspase 6 protein with a compound as described herein.
    Type: Application
    Filed: November 20, 2020
    Publication date: June 29, 2023
    Inventors: Adam R. Renslo, Michelle R. Arkin, R. Jeffrey Neitz, Raymond Ng, Peter Lee
  • PROTEIN-PROTEIN INTERACTION STABILIZERS
    Publication number: 20230142739
    Abstract: Provided herein, inter alia, are stabilizers of protein-protein interactions and methods of identifying and using the same.
    Type: Application
    Filed: April 2, 2021
    Publication date: May 11, 2023
    Inventors: Michelle R. Arkin, Lucas Brunsveld, Christian Ottmann, Adam R. Renslo, R. Jeffrey Neitz, Mengqi Zhong, Kenneth K. Hallenbeck, Priyadarshini Jaishankar, Shubhankar Dutta, John K. Morrow, Eline Sijbesma, Bente Aminhan Somsen, Galen Patrick Miley, Emira Josien Visser, Peter James Cossar, Madita Wolter, Thorsten Genski, Laura Mariana Levy, Torsten Hoffmann, Dimitrios Tzalis, Dario Valenti, Markella Konstantinidou
  • TASPASE1 INHIBITORS AND USES THEREOF
    Publication number: 20230052528
    Abstract: Disclosed herein, inter alia, are compounds and methods for inhibiting Taspase1 and the treatment of cancer.
    Type: Application
    Filed: November 20, 2020
    Publication date: February 16, 2023
    Inventors: Michelle R. Arkin, R. Jeffrey Neitz, Adam R. Renslo, James Hsieh, Shubhankar Dutta, Clifford Bryant, William J. Moore, Alex G. Waterson, Lidia Sambucetti, Somnath Jana, lan M. Romaine, Alexander P. Lamers, Yassir Younis Adam, Claire Repellin
  • K-Ras modulators
    Patent number: 11541044
    Abstract: Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: January 3, 2023
    Assignees: The Regents of the University of California, Leidos Biomedical Research, Inc.
    Inventors: Frank McCormick, Adam R. Renslo, David Turner, Stephan Gysin, Anna E. Maciag, Oleg Chertov
  • METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
    Publication number: 20220226508
    Abstract: Provided, inter alia, are methods and compositions for treating epilepsy. In one aspect, provided herein is a method of selecting a compound for treating epilepsy, said method includes, contacting a test compound with 5-hydroxytryptamine-2B receptor (5-HT2B), and measuring the 5-HT2B agonistic activity of the test compound. In another aspect, provided herein is a method of treating an epilepsy in a subject in need thereof. The method includes administering to said subject an effective amount of a 5-HT2B specific receptor agonist.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 21, 2022
    Inventors: Scott C. BARABAN, Aliesha L. GRIFFIN, Adam R. RENSLO, Priyadarshini JAISHANKAR
  • CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
    Publication number: 20220017559
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 22, 2021
    Publication date: January 20, 2022
    Inventors: Adam R. Renslo, Erica M.W. Lauterwasser, Shaun D. Fontaine, Benjamin B. Spangler, James A. Wells
  • Modulators of the eIF2alpha pathway
    Patent number: 11220477
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: January 11, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • K-RAS MODULATORS
    Publication number: 20210196695
    Abstract: Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.
    Type: Application
    Filed: October 28, 2020
    Publication date: July 1, 2021
    Inventors: Frank MCCORMICK, Adam R. Renslo, David Turner, Stephan Gysin, Anna E. Maciag, Oleg Chertov
  • Cyclic peroxides as prodrugs for selective delivery of agents
    Patent number: 11014955
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: May 25, 2021
    Assignee: The Regents of the University of California
    Inventors: Adam R. Renslo, Erica M. W. Lauterwasser, Shaun D. Fontaine, Benjamin B. Spangler, James A. Wells
  • K-Ras modulators
    Patent number: 10857140
    Abstract: Provided herein, inter alia, are methods and compounds of formula (I) for inhibiting K-Ras and for treating cancer.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: December 8, 2020
    Assignees: The Regents of the University of California, Leidos Biomedical Research, Inc.
    Inventors: Frank McCormick, Adam R. Renslo, David Turner, Stephan Gysin, Anna E. Maciag, Oleg Chertov
  • CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
    Publication number: 20200317714
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 8, 2020
    Inventors: Adam R. Renslo, Erica M.W. Lauterwasser, Shaun D. Fontaine, Benjamin B. Spangler, James A. Wells
  • Cyclic peroxides as prodrugs for selective delivery of agents
    Patent number: 10662215
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: May 26, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adam R. Renslo, Erica M. W. Lauterwasser, Shaun D. Fontaine, Benjamin B. Spangler, James A. Wells
  • Compositions, methods of use, and methods of treatment
    Patent number: 10604493
    Abstract: Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: March 31, 2020
    Assignees: University of South Florida, The Regents of the University of California
    Inventors: Yu Chen, Derek Nichols, Adam R. Renslo, Priyadarshini Jaishankar, Erica M. W. Lauterwasser
  • MODULATORS OF THE EIF2ALPHA PATHWAY
    Publication number: 20190375704
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: May 21, 2019
    Publication date: December 12, 2019
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
    Publication number: 20190284224
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: March 26, 2019
    Publication date: September 19, 2019
    Inventors: Adam R. Renslo, Erica M.W. Lauterwasser, Shaun D. Fontaine, Benjamin B. Spangler, James A. Wells
  • Modulators of the eIF2alpha pathway
    Patent number: 10343981
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: July 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Cyclic peroxides as prodrugs for selective delivery of agents
    Patent number: 10287312
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: May 14, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adam R. Renslo, Erica M. W. Lauterwasser, Shaun D. Fontaine, Benjamin B. Spangler, James A. Wells
  • K-RAS MODULATORS
    Publication number: 20180289683
    Abstract: Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.
    Type: Application
    Filed: May 6, 2016
    Publication date: October 11, 2018
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, LEIDOS BIOMEDICAL RESEARCH, INC.
    Inventors: Frank MCCORMICK, Adam R. RENSLO, David TURNER, Stephan GYSIN, Anna E. MACIAG, Oleg CHERTOV
  • Modulation of K2P channels
    Patent number: 9862684
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment of diseases, for example pain, neurodegeneration, or mood disorders, and for modulating the activity of a K2P channel.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: January 9, 2018
    Assignee: The Regents of the University of California
    Inventors: Daniel L. Minor, Jr., Sviatoslav N. Bagriantsev, Adam R. Renslo
  • MODULATORS OF THE EIF2ALPHA PATHWAY
    Publication number: 20170342020
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: June 5, 2017
    Publication date: November 30, 2017
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas