Abstract: Downhole tools and methods and systems related thereto, wherein the downhole tool comprises a body having a body inner flow bore, a port in the body, a valve member axially rotatable relative to the body between an open position and a closed position, and an actuable drive shaft of a gearbox and a motor connected to the valve member to axially rotate the valve member. The open position allows fluid communication between the port and the body inner flow bore and the closed position prevents fluid communication between the port and the body inner flow bore, and the gearbox and the motor are in the body and axially offset from the body inner flow bore.

Abstract: Downhole tools and methods and systems related thereto, wherein the downhole tool comprises a body having a body inner flow bore, a port in the body, a valve member axially rotatable relative to the body between an open position and a closed position, and an actuable drive shaft of a gearbox and a motor connected to the valve member to axially rotate the valve member. The open position allows fluid communication between the port and the body inner flow bore and the closed position prevents fluid communication between the port and the body inner flow bore, and the gearbox and the motor are in the body and axially offset from the body inner flow bore.

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

Abstract: An example ball valve includes a body defining a first valve port and a second valve port circumferentially offset from each other on the body by 180°. A valve member is positioned within the body and defines an inlet port and first and second outlet ports extending perpendicularly from the inlet port in opposing directions. First and second sealing elements are mounted on the valve member within corresponding first and second annular grooves, the first and second sealing elements being circumferentially offset from each other on the valve member by 180° and circumferentially offset from the first and second outlet ports by 90°. First and second seal systems are positioned within the first and second valve ports, respectively, and each include a valve seat engageable with the first and second sealing elements, a boost piston, and a bias spring.

Abstract: An actuating apparatus for a downhole valve including a tubular body, which includes an axial bore that extends through the body. The actuating apparatus also includes an operating member that is adapted to move relative to the tubular body. The movement of the operating member relative to the tubular body is between a first position and a second position such that fluid contained within a reservoir is displaced when such a downhole valve is actuated. The actuating apparatus is adapted to be fluidly coupled to the downhole valve.

Abstract: An example ball valve includes a body defining a first valve port and a second valve port circumferentially offset from each other on the body by 180°. A valve member is positioned within the body and defines an inlet port and first and second outlet ports extending perpendicularly from the inlet port in opposing directions. First and second sealing elements are mounted on the valve member within corresponding first and second annular grooves, the first and second sealing elements being circumferentially offset from each other on the valve member by 180° and circumferentially offset from the first and second outlet ports by 90°. First and second seal systems are positioned within the first and second valve ports, respectively, and each include a valve seat engageable with the first and second sealing elements, a boost piston, and a bias spring.

Abstract: A downhole valve assembly operable to control production fluid flow around an obstruction in a production tubing string. The obstruction may be caused by another valve or valve assembly located in the production tubing string, where the valve is closed and blocks flow through the production tubing. The downhole valve assembly comprises a tubular body that includes an axial passage extending through the body and one or more ports extending substantially radially through the body. The downhole valve assembly also includes one or more actuating members operable to move relative to the body. Movement of the actuating members selectively opens the ports such that a fluid flow path through the ports is defined between an annulus region outside of the valve assembly and the axial passage such that the blockage can be bypassed.

Abstract: An actuating apparatus for a downhole valve including a tubular body. The tubular body includes an axial bore that extends through the body. An inlet port extends radially and at least partially through the tubular body. When open, the inlet port is arranged to be in fluid communication with a region uphole of the actuating apparatus. The actuating apparatus also includes an actuating member that is operable by application of fluid pressure from a region uphole of the actuating apparatus via an open inlet port to actuate the valve.

Abstract: A tubing mounted completion assembly that includes at least one downhole valve assembly and at least one contingency device. The contingency device or devices can be associated with and can be separate from the downhole valve assembly. The contingency device or devices can be adapted to operate upon failure of operation of the downhole valve assembly.

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

Abstract: A downhole apparatus (10) adapted to be run on a workstring in a well bore. The apparatus has a body (12) including ports (42) and a valve (26) which is rotatable to open and close the ports to selectively allow fluid flow through the body between regions of a well bore above and below the apparatus. The valve is rotated via a gearbox (28) and motor (30) in the apparatus. A sealing arrangement between the valve and body is also described. A method of running the apparatus in a well bore and monitoring pressure above the apparatus in order to control opening and closing of the valve under predetermined conditions is presented.

Abstract: A downhole apparatus (10) adapted to be run on a workstring in a well bore. The apparatus has a body (12) including ports (42) and a valve (26) which is rotatable to open and close the ports to selectively allow fluid flow through the body between regions of a well bore above and below the apparatus. The valve is rotated via a gearbox (28) and motor (30) in the apparatus. A sealing arrangement between the valve and body is also described. A method of running the apparatus in a well bore and monitoring pressure above the apparatus in order to control opening and closing of the valve under predetermined conditions is presented.

Abstract: There is herein defined a control apparatus operable to control the opening and closing of downhole flow control devices. The apparatus includes first and second indexing modules, which are arranged in fluid communication with a respective downhole control device. Each of the modules includes two inlet ports and two outlet ports, where the inlet ports are each in fluid communication with one of two control lines. The first module is operable to open and close a first downhole control device on application of fluid pressure through the first control line and the second module is operable to open and close a second downhole control device on application of fluid pressure through the second control line.

Abstract: An apparatus comprising at least one processor and at least one memory including computer program code. The at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus at least to detect a first user input corresponding to a first command, begin a first process corresponding to a second command in response to said first user input, detect a second user input corresponding to the second command and complete said first process in response to said second user input.

Abstract: A support assembly for a deformable sealing element of a downhole tool, such as a packer or a bridge plug. The assembly comprises a first and a second support device. The first and the second support devices each comprise at least one support member which support member includes a plurality of segments located on an outer surface thereof, the segments being arranged such that when moved radially outwardly they maintain a continuous surface abutting the respective end of the sealing element. A downhole tool having a deformable sealing element and including a support assembly for a deformable sealing element is described.

Abstract: An electronic actuation system for a pressure equalizing device in a downhole apparatus such as a wellbore plug is described. The system includes a pressure sensor for measuring pressure in the wellbore, and means for setting a reference pressure value using a measurement from the pressure sensor. In a method of use, an applied pressure value is determined using a measurement from the pressure sensor and the reference pressure value, and the device is actuated, or opened, when the applied pressure meets a pre-determined condition, such as falling within a pressure window for certain time period. The invention allows natural changes in wellbore pressure to be accounted for when detecting a pressure actuation event.

Abstract: There is herein defined a control apparatus operable to control the opening and closing of downhole flow control devices. The apparatus includes first and second indexing modules, which are arranged in fluid communication with a respective downhole control device. Each of the modules includes two inlet ports and two outlet ports, where the inlet ports are each in fluid communication with one of two control lines. The first module is operable to open and close a first downhole control device on application of fluid pressure through the first control line and the second module is operable to open and close a second downhole control device on application of fluid pressure through the second control line.

Abstract: A valve for use in a downhole tool The valve has an inlet communicating with the work string from which it is anchored. The inlet provides a flow path of a first cross-sectional area. A sealing assembly comprising a spring biased seal cap moves within an outer tubular body to open and close a number of ports arranged through the body. The ports provide a flow path of a combined cross-sectional area greater than the first cross-sectional area and the valve is arranged such that fluid flow through the inlet moves the seal cap to open the valve and create an unimpeded flow path between the inlet and the ports with negligible pressure drop. An embodiment including a shear ring is described to facilitate pressure testing above. A further embodiment includes a load adjuster to assist in closing the valve. The valve can be a high lift injection valve.

Abstract: A support assembly for a deformable sealing element of a downhole tool, such as a packer or a bridge plug. The assembly comprises a first and a second support device. The first and the second support devices each comprise at least one support member which support member includes a plurality of segments located on an outer surface thereof, the segments being arranged such that when moved radially outwardly they maintain a continuous surface abutting the respective end of the sealing element. A downhole tool having a deformable sealing element and including a support assembly for a deformable sealing element is described.