Abstract: A light-weight reciprocating element is disclosed. The reciprocating element may include a body defining a cavity, the body having a closed distal end and an open proximal end opposite the closed distal end, wherein the body is configured to apply a pressure to a working fluid. The cavity extends from the open proximal end towards the closed distal end. The reciprocating element may include an insert disposed in the cavity, the insert is configured to prevent debris from accumulating within the cavity.

Abstract: Systems and methods may be provided that may enable an individual to retrieve one or more prescription products (e.g., product refills) from a self-service retrieval location such as a counter, drive-thru, drop box, or kiosk. A unique-machine readable code may be associated with a particular one or more prescription products (e.g., associated with a medical prescription of a patient). The unique machine-readable code may be provided to a computing device of the individual, along with an anticipated time of preparedness of the one or more products for retrieval at the retrieval location. Identification of the unique machine-readable code may result in dispensing of the one or more prescription products associated at the retrieval location.

Abstract: A computer-implemented method includes receiving a task performance request; retrieving a stored task specification corresponding to the task performance request; generating a task implementation request including the stored task specification and an execution context; generating a task implementation corresponding to the task implementation request, the task implementation including a sequence of task execution commands; and causing execution of the sequence of task execution commands.

Abstract: An electronic module for a wearable sensor system including a housing, a support frame, a sensor module and an attachment element for the sensor module. The support frame includes several partitions and defines several compartments within the housing, wherein the attachment element is a component part that is separate from the support frame and is attached to the support frame. The sensor module is located in one of the compartments, termed sensor compartment, and is attached to the attachment element. Moreover, a wearable sensor device is shown.

Abstract: This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4 (referred to as “aP2”) for use in treating disorders such as diabetes, obesity, cardiovascular disease, fatty liver disease, and/or cancer, among others. In one aspect, improved treatments for aP2 mediated disorders are disclosed in which serum aP2 is targeted and the biological activity of aP2 is neutralized or modulated using low-binding affinity aP2 monoclonal antibodies, providing lower fasting blood glucose levels, improved systemic glucose metabolism, increased systemic insulin sensitivity, reduced fat mass, reduced liver steatosis, reduced cardiovascular disease and/or a reduced risk of developing cardiovascular disease.

Abstract: The various implementations described herein include techniques and apparatuses for handwriting and other user gesture detection and recognition. In one aspect, a method includes receiving, via one or more sensors of a wearable device worn by a user, neuromuscular data generated from performance of a hand gesture by the user. The method also includes generating, using one or more encoders, one or more encodings by encoding the neuromuscular data; and identifying, using a language model, one or more terms from the one or more encodings. The method further includes causing display of the one or more terms to the user during performance of the hand gesture.

Abstract: Systems, methods, and apparatuses for generating and using machine learning models using genetic data. A set of input features for training the machine learning model can be identified and used to train the model based on training samples, e.g., for which one or more labels are known. As examples, the input features can include aligned variables (e.g., derived from sequences aligned to a population level or individual references) and/or non-aligned variables (e.g., sequence content). The features can be classified into different groups based on the underlying genetic data or intermediate values resulting from a processing of the underlying genetic data. Features can be selected from a feature space for creating a feature vector for training a model. The selection and creation of feature vectors can be performed iteratively to train many models as part of a search for optimal features and an optimal model.

Abstract: A vehicle storage system includes a base that is configured to be disposed on seating assemblies within a rear seating space. A first partition is coupled to the base, and the first partition extends along a first edge of the base. A second partition is spaced from the first partition. The second partition is coupled to the base and extends along a second opposing edge of the base. A cross member is coupled to a top edge of each of the first partition and the second partition. The cross member extends adjacent to a headliner.

Abstract: Glass-based articles that include a compressive stress layer extending from a surface of the glass-based article to a depth of compression are formed by exposing glass-based substrates to water vapor containing environments. The methods of forming the glass-based articles may include elevated pressures and/or multiple exposures to water vapor containing environments.

Abstract: Methods for a reusable space vehicle to land at substantially the same location as its launching site. The vehicle traveling in a particular orbit, which is a repeating ground track orbit, allows for launching and landing at the same location once per day. The repeating ground track orbits that allow for launching and landing at the same location once per day overfly the launch and landing site once per day. Launching and landing at the same site provides a number of direct advantages. For example, the just-landed vehicle may be transported a relatively short distance to the launch site, reconditioned relatively quickly, and be ready for a quick turn-around launch.

Abstract: Configurations are described for assisting execution of a percutaneous procedure while protecting the vascular pathway to the target treatment area. One example is directed to an embolic protection system for deploying a device to a distal location across a diseased vessel, the embolic protection system which may include an expandable introducer, an embolic protection device, and a loading sleeve.

Abstract: An electrical header for use in an electrical connector assembly includes a body adapted to mount to an object and having an opening formed therethrough for receiving an electrical terminal. The body further defines a plug on a first side thereof and adapted to engage with a mating electrical connector of the assembly. The plug includes a pair of first opposing sidewalls extending from the body and defining a locking feature adapted to engage with a corresponding locking feature of the mating connector, and a pair of second opposing sidewalls extending from the body and defining a keying feature. The first and second pairs of opposing sidewalls are adapted to mate with a first mating connector oriented in a first direction, and mate with a second mating connector oriented in a second direction distinct from the first direction.

Abstract: In some examples, an embolic protection system is provided for deploying a device in a diseased vessel of a vasculature, the embolic protection system comprising: an embolic protection device (EPD) including: an EPD shaft; a dual-hoop filter provided at a distal end of the EPD shaft, the dual-hoop filter including a distal hoop provided at a distal end of the dual-hoop filter, and a proximal hoop provided at a proximal end of the dual-hoop filter; and a filter actuator located at or towards a proximal end of the EPD, the filter actuator operable to selectively open or close the distal hoop and the proximal hoop of the dual-hoop filter.

Abstract: A drug delivery device for setting and dispensing doses of a liquid drug is described. The device includes a housing and a dose setting and drive mechanism with a dose setting member and a dose setting drum. The dose setting and drive mechanism is configured to perform a dose setting operation for setting a dose to be delivered by the drug delivery device by rotating the dose setting member relative to the housing and a dose delivery operation for delivering the set dose during rotation of the dose setting drum relative to dose setting member the housing. The dose setting drum includes an array of encoder features at its proximal end. The dose setting member has at least one aperture located in a proximal end surface that is coincident with at least a portion of the array of encoder features of the dose setting drum.

Abstract: In one embodiment, a method of intermingling stereoscopic and conforming virtual content to a bounded surface is performed at a device that includes one or more processors, non-transitory memory, and one or more displays. The method includes displaying a bounded surface within a native user computer-generated reality (CGR) environment, wherein the bounded surface is displayed based on a first set of world coordinates characterizing the native user CGR environment. The method further includes displaying a first stereoscopic virtual object within a perimeter of a first side of the bounded surface, wherein the first stereoscopic virtual object is displayed in accordance with a second set of world coordinates that is different from the first set of world coordinates characterizing the native user CGR environment.

Abstract: The present disclosure relates to a drug delivery device for setting and dispensing doses of a liquid drug. The device comprises a housing and a dose setting and drive mechanism with a dose setting member. The dose setting and drive mechanism is, at least partially, arranged within the housing and is configured to perform a dose setting operation for selecting a dose to be delivered by the drug delivery device by moving the dose setting member relative to the housing and a dose delivery operation for delivering the set dose by axially displacing the dose setting member along an axis. The maximum radial extension perpendicular to the axis of the dose setting member is smaller than the maximum radial extension of a region of the housing located adjacent to the dose setting member.

Abstract: The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.

Abstract: Methods and systems may support dynamic, real-time or near-real-time processing, analysis, and processing of data to automatically identify and obtain coupons corresponding to consumer products such that, in response to receiving a request to purchase one or more products, qualifying coupons may be automatically identified, retrieved, and applied to the purchase.

Abstract: A system and method are provided for simulating circuits that transmit bidirectional signals between some ports using simulators designed originally for electrical circuits and systems, that eliminate the need for different port interfaces. The system and method can be applied to simulate photonic circuits either standalone or integrated with electrical circuits and systems. In one method implemented by the system potential and flow representations, available for example in Verilog-A simulators, are used to create bidirectional signals on a single bus line to transmit optical signals. In another method implemented by the system, the system auto-configures each optical port type as left or right at runtime or during a pre-simulation initialization to allow for bidirectional signals with a single port interface.