Abstract: The present disclosure relates to a drug delivery device for setting and dispensing doses of a liquid drug. The device comprises a housing and a dose setting and drive mechanism with a dose setting member. The dose setting and drive mechanism is, at least partially, arranged within the housing and is configured to perform a dose setting operation for selecting a dose to be delivered by the drug delivery device by moving the dose setting member relative to the housing and a dose delivery operation for delivering the set dose by axially displacing the dose setting member along an axis. The maximum radial extension perpendicular to the axis of the dose setting member is smaller than the maximum radial extension of a region of the housing located adjacent to the dose setting member.

Abstract: The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.

Abstract: Methods and systems may support dynamic, real-time or near-real-time processing, analysis, and processing of data to automatically identify and obtain coupons corresponding to consumer products such that, in response to receiving a request to purchase one or more products, qualifying coupons may be automatically identified, retrieved, and applied to the purchase.

Abstract: A system and method are provided for simulating circuits that transmit bidirectional signals between some ports using simulators designed originally for electrical circuits and systems, that eliminate the need for different port interfaces. The system and method can be applied to simulate photonic circuits either standalone or integrated with electrical circuits and systems. In one method implemented by the system potential and flow representations, available for example in Verilog-A simulators, are used to create bidirectional signals on a single bus line to transmit optical signals. In another method implemented by the system, the system auto-configures each optical port type as left or right at runtime or during a pre-simulation initialization to allow for bidirectional signals with a single port interface.

Abstract: The present disclosure refers to a drug delivery device for setting and dispensing doses of a liquid drug which may be used together with a module for detecting the amount of a dose selected and/or delivered. The device comprises a housing and a dose setting and drive mechanism with a dose setting member. The dose setting and drive mechanism is configured to perform a dose setting operation for selecting a dose to be delivered by rotating the dose setting member relative to the housing and a dose delivery operation for delivering the set dose by pushing the dose setting member axially towards the housing without relative rotation therebetween. The dose setting member comprises a set of axially directed stop teeth formed at its distal end which are configured to engage with a set of counterstop teeth located on the housing at the end of the dose delivery operation.

Abstract: Systems and methods may be provided that may enable an individual to retrieve one or more prescription products (e.g., product refills) from a self-service retrieval location such as a counter, drive-thru, drop box, or kiosk. The individual may identify a medical prescription, and a unique-machine readable code may be generated, wherein the code is associated with the medical prescription and a particular station at an identified retrieval location. The unique machine-readable code may be transmitted to a computing device of the individual, who may scan the code at particular station to retrieve one or more prescription products associated with the medical prescription.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: A shim or badge is affixed to a golf cub body to produce a cap-back iron, giving the appearance of a hollow-body iron. In this way, the golf club can be manufactured with the performance benefits of a game improvement iron, while providing the appearance of a blade, player's iron, and/or a hollow-body iron. For example, by using a lightweight and rigid shim or badge to close a cavity opening and extend into the toe portion of the golf club body, the golf club head can provide increased stiffness in the topline, while lowering CG. Various shim or badge arrangements and materials can be used, and a filler material and/or damper can be included within the cavity to improve sound and feel, while minimizing loss in COR.

Abstract: A system and method that enables the ongoing communication, tracking, and management review of feedback among a population of workers and their management.

Abstract: To extract information from a customer's insurance card, an insurance policy recordation system obtains a scanned image of an insurance card and analyzes text in the insurance card image to identify labels describing insurance policy characteristics and insurance policy values corresponding to the insurance policy characteristics. The insurance policy recordation system compares the identified insurance policy values to a set of stored identifiers associated with various insurance plans. If the insurance policy values match one or more of the identifiers, the insurance policy recordation system may determine that the insurance policy values are valid and that the customer has the matching insurance plan. The insurance policy recordation system may obtain additional insurance policy information for the customer based on the stored information in association with the matching insurance plan.

Abstract: Engineered antibody compounds and conjugates thereof, are provided, said antibody compounds and conjugates thereof are useful as agents for cancer immunotherapy. Engineered antibody compounds may include one or more amino acid residue substitutions within the constant regions of the antibody engineered into a parental antibody. Amino acid residue substitutions may include substitution of cysteine or alanine.

Abstract: Systems and methods may be provided that may enable an individual to retrieve one or more prescription products (e.g., product refills) from a self-service retrieval location such as a counter, drive-thru, drop box, or kiosk. A unique-machine readable code may be associated with a particular one or more prescription products (e.g., associated with a medical prescription of a patient). The unique machine-readable code may be provided to a computing device of the individual, along with an anticipated time of preparedness of the one or more products for retrieval at the retrieval location. Identification of the unique machine-readable code may result in dispensing of the one or more prescription products associated at the retrieval location.

Abstract: Systems and methods of the present disclosure are directed toward digital signal processing using machine-learned differentiable digital signal processors. For example, embodiments of the present disclosure may include differentiable digital signal processors within the training loop of a machine-learned model (e.g., for gradient-based training). Advantageously, systems and methods of the present disclosure provide high quality signal processing using smaller models than prior systems, thereby reducing energy costs (e.g., storage and/or processing costs) associated with performing digital signal processing.

Abstract: A method for controlling an Air Handling Unit (AHU) of an HVAC (Heating, Ventilating and Air Conditioning) system servicing a building space of a building includes determining when there is an elevated pathogen transmission risk in the building space. In response to determining that there is an elevated pathogen transmission risk in the building space, the AHU is controlled to adjust operation of the AHU to alleviate the elevated pathogen transmission risk.

Abstract: A combustion burner employed in a submerged combustion vessel used to melt high index glass includes an arch positioned on a burner in the submerged combustion vessel. An amount of combustible gas flows through a first port disposed in a first haunch of the arch and through a second port disposed in a second haunch of the arch. Fuel is supplied through an end port in a fuel supply line. The end port is disposed under the arch. An amount of glass is fed into the submerged combustion vessel and is melted inside the submerged combustion vessel by igniting the burner. Some of the melted glass at least partially solidifies against a wall of the submerged combustion vessel such that the melted glass is contained in a vessel of itself.

Abstract: Disclosed herein, inter alia, are trioxolane compounds and methods of using the same for treatment and detection of diseases.

Abstract: Systems and methods may be provided that may enable an individual to retrieve one or more prescription products (e.g., product refills) from a self-service retrieval location such as a counter, drive-thru, drop box, or kiosk. The individual may identify a medical prescription, and a unique-machine readable code may be generated, wherein the code is associated with the medical prescription and a particular station at an identified retrieval location. The unique machine-readable code may be transmitted to a computing device of the individual, who may scan the code at particular station to retrieve one or more prescription products associated with the medical prescription.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter di of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Devices, methods, and systems for monitoring and/or assessing compliance with infectious disease guidance for reducing infectious disease transmissions are described herein. The systems may include sensing devices at or within a facility and computing devices to compare data based on outputs from the sensing devices with guidance and/or recommendations for mitigating infectious disease transmission. Various compliance parameters may be identified as being relevant to the guidelines and measurable with outputs from the sensing devices. Various compliance parameters may be identified as being relevant to the guidelines, but not measurable with outputs from the sensing devices. The compliance parameters may be individually scored or scored in groups, including the compliance parameters not measureable with outputs from the sensing devices, and a score relative to a facility or group of facilities may be provided. The scores may be presented to via a dashboard.

Abstract: A system and method that enables the ongoing communication, tracking, and management review of feedback among a population of workers and their management.