Abstract: The invention refers to a capillary insert (100) or cap that comprises a cone (110) in its upper part that ends in a skirt (120) forming a single piece, which leaves evidence if something in the insert (100) has changed or has been altered improperly. The capillary insert or cap of the present invention prevents its reuse and tampering through one or more breaking zones (130) located along the insert.

Abstract: Provided herein are methods of preparing a template nucleic acid for next-generation sequencing. The methods comprise performing primer extension using c7dGTP instead of dGTP, which then allows for the input nucleic acids to be selectively digested by c7dGTP-resistant restriction enzymes, thereby enriching the template nucleic acid prior to next-generation sequencing library preparation.

Abstract: Controlling motion of an autonomous vehicle may comprise determining a state space representation of the environment associated with the autonomous vehicle based at least in part on sensor data. The autonomous vehicle may parameterize the state space according to arc length and lateral distance from a route reference. The autonomous vehicle may determine a state in the state space upon which to base trajectory generation (e.g., via a tree search, via a state space sampling technique based on cost) and may determine a set of control instructions (i.e., a trajectory) that would bring the autonomous vehicle to the arc length and lateral distance specified by the state. Determining the state for generating the trajectory may be based on a heuristic for determining approximately where the trajectory would bring the vehicle, since the arc length parameterized state space doesn't include an indication of location.

Abstract: The disclosed technology is generally directed to downlink prioritization of on-orbit spaceborne data. In one example of the technology, image metadata and raw image data obtained from sensors on the constrained-environment device are stored. The raw image data includes a plurality of images. A plurality of images tiles is provided such that the plurality of images tiles includes, for each image of the plurality of images, evenly-spaced portions of the image. Via an embedding-generation model, a plurality of embeddings is generated based on the plurality of image tiles. The plurality of embeddings is used to perform a prioritization of image tiles among the plurality of image tiles. During a downlink session from the constrained-environment device, image tiles from among the plurality of image tiles are downlinked based, at least in part, on the prioritization.

Abstract: A vehicle computing system may implement techniques to determine whether two objects in an environment are related as an articulated object. The techniques may include applying heuristics and algorithms to object representations (e.g., bounding boxes) to determine whether two objects are related as a single object with two portions that articulate relative to each other. The techniques may include predicting future states of the articulated object in the environment. One or more model(s) may be used to determine presence of the articulated object and/or predict motion of the articulated object in the future. Based on the presence and/or motion of the articulated object, the vehicle computing system may control operation of the vehicle.

Abstract: The techniques discussed herein may comprise an autonomous vehicle guidance system that generates a group of candidate trajectories based at least in part on sensor data. This group of candidate trajectories is clustered into two or more clusters and one or more representative trajectories may be determined for each cluster. The representative trajectory may be one of the trajectories in the cluster or a separately determined trajectory that represents the trajectories in a cluster, such as a mean or median trajectory. The representative trajectory may be used to predict how a dynamic object would react to the representative trajectory. This prediction may be used to determine potentially different costs associated with the different trajectories of the cluster with which the representative trajectory is associated. These costs may include costs to induce following behavior by the autonomous vehicle and/or cost(s) associated with conditionally available roadway portions.

Abstract: A masked packet checksum is utilized to provide error detection and/or error correction for only discrete portions of a packet, to the exclusion of other portions, thereby avoiding retransmission if transmission errors appear only in portions excluded by the masked packet checksum. A bitmask identifies packet portions whose data is to be protected with error detection and/or error correction schemes, packet portions whose data is to be excluded from such error detection and/or error correction schemes, or combinations thereof. A bitmask can be a per-packet specification, incorporated into one or more fields of individual packets, or a single bitmask can apply equally to multiple packets, which can be delineated in numerous ways, and can be separately transmitted or derived. Bitmasks can be generated at higher layers with lower layer mechanisms deactivated, or can be generated lower layers based upon data passed down.

Abstract: A vehicle computing system may implement techniques to determine whether two objects in an environment are related as an articulated object. The techniques may include applying heuristics and algorithms to object representations (e.g., bounding boxes) to determine whether two objects are related as a single object with two portions that articulate relative to each other. The techniques may include predicting future states of the articulated object in the environment. One or more model(s) may be used to determine presence of the articulated object and/or predict motion of the articulated object in the future. Based on the presence and/or motion of the articulated object, the vehicle computing system may control operation of the vehicle.

Abstract: The invention provides a compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle; and R2 is an optionally substituted 5- or 6-membered aromatic heterocycle. Also provided are pharmaceutical compositions comprising a compound of formula (I).

Abstract: Disclosed is a substance which down-regulates the activity of a MAST gene, or the activity of a transcription or translation product of a MAST gene, for use in the prevent and/or treatment of an inflammatory skin condition in a mammalian subject.

Abstract: Various embodiments are described herein for a system and a method for assessing a risk of ventricular arrhythmias for a patient. For example, the method may comprise receiving ECG data obtained from the patient; analyzing the ECG data to detect abnormal QRS peaks; determining the risk of ventricular arrhythmias for the patient based on the detected abnormal QRS peaks; and providing an indication of the risk of ventricular arrhythmias for the patient. The system may be configured to perform this method.

Abstract: The invention refers to a capillary insert (100) or cap that comprises a cone (110) in its upper part that ends in a skirt (120) forming a single piece, which leaves evidence if something in the insert (100) has changed or has been altered improperly. The capillary insert or cap of the present invention prevents its reuse and tampering through one or more breaking zones (130) located along the insert.

Abstract: A vehicle computing system may implement techniques to determine whether two objects in an environment are related as an articulated object. The techniques may include applying heuristics and algorithms to object representations (e.g., bounding boxes) to determine whether two objects are related as a single object with two portions that articulate relative to each other. The techniques may include predicting future states of the articulated object in the environment. One or more model(s) may be used to determine presence of the articulated object and/or predict motion of the articulated object in the future. Based on the presence and/or motion of the articulated object, the vehicle computing system may control operation of the vehicle.

Abstract: Techniques and algorithms for monitoring network congestion and for triggering a flow to follow a new path through a network. The network is monitored, and network feedback data is acquired, where that data indicates whether the network is congested. If the network is congested, a feedback-driven algorithm can trigger a flow to follow a new path. By triggering the flow to follow the new path, congestion in the network is reduced. To identify congestion, the feedback data is analyzed to determine whether flows are colliding. The feedback-driven algorithm determines that a network remapping event is to occur in an attempt to alleviate the congestion. A flow is then selected to be remapped to alleviate the congestion.

Abstract: The invention provides a compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle; and R2 is an optionally substituted 5- or 6-membered aromatic heterocycle. Also provided are pharmaceutical compositions comprising a compound of formula (I).

Abstract: Disclosed is a substance which down-regulates the activity of a MAST gene, or the activity of a transcription or translation product of a MAST gene, for use in the prevent and/or treatment of an inflammatory skin condition in a mammalian subject.

Abstract: The techniques discussed herein include modifying a Kalman filter to additionally include a loss component that dampens the effect measurements with large errors (or measurements indicating states that are rather different than the predicted state) have on the Kalman filter and, in particular, the updated uncertainty and/or updated prediction. In some examples, the techniques include scaling a Kalman gain based at least in part on a loss function that is based on the innovation determined by the Kalman filter. The techniques additionally or alternatively include a reformulation of a Kalman filter that ensures that the uncertainties determined by the Kalman filter remain symmetric and positive definite.

Abstract: A multi-threaded imperative programming language includes a language construct defining a function call. A circuit implementation for the construct includes a first pipeline, a second pipeline, and a third pipeline. The first hardware pipeline outputs variables to a first queue and outputs parameters for the function to a second queue. The second hardware pipeline obtains the function parameters from the second queue, performs the function, and stores the results of the function in a third queue. The third hardware pipeline retrieves the results generated by the second pipeline from the second queue and retrieves the variables from the first queue. The third hardware pipeline performs hardware operations specified by the source code using the variables and the results of the function. A single instance of the circuit implementation can be utilized to implement calls to the same function made from multiple locations within source code.