Patents by Inventor Ae Nim Pae

Ae Nim Pae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180119169
    Abstract: Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.
    Type: Application
    Filed: September 20, 2017
    Publication date: May 3, 2018
    Applicant: Korea Institute of Science and Technology
    Inventors: Do Hee KIM, Seul Gi Shin, Sung Su Lim, Ae Nim Pae, Dong Jin Kim, Yun Kyung Kim
  • Publication number: 20180057527
    Abstract: The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of consisting of a carbazole compound which shows excellent anti-proliferative efficacy against hepatitis C virus (HCV), a pharmaceutically acceptable salt thereof, a hydrate thereof, and an isomer thereof; an anti-virus pharmaceutical composition including the novel compound as an active ingredient; a pharmaceutical composition for preventing or treating liver diseases caused by hepatitis C virus; and a method of preparing the novel compound.
    Type: Application
    Filed: August 25, 2017
    Publication date: March 1, 2018
    Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Gyo Chang KEUM, Eunice Eun Kyeong KIM, Sung Key JANG, Hee Sun KIM, Ae Nim PAE, Hua LI, Jin Hyeong PARK, Jin Sook KWAK
  • Publication number: 20170298011
    Abstract: The present disclosure relates to an ?-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.
    Type: Application
    Filed: September 24, 2015
    Publication date: October 19, 2017
    Inventors: Ki Duk PARK, ChangJoon Justin LEE, Dong Jin KIM, Ae Nim PAE, Hyun Ah CHOO, Sun Joon MIN, Yong Koo KANG, Yun Kyung KIM, Hyo Jung SONG, Ji Won CHOI, Min Ho NAM, Jun Young HEO, Seul Ki YEON, Bo Ko JANG, Eun Ji JU, Seon Mi JO, Jong-Hyun PARK
  • Patent number: 9493423
    Abstract: Disclosed herein are an N-(pyrazolylmethyl)arylsulfonamide derivative useful as a calcium ion channel blocker, a pharmaceutically acceptable salt thereof, and the medicinal use thereof as a therapeutic agent using its calcium ion channel blocking effect.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: November 15, 2016
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ghil Soo Nam, Kyung Il Choi, Jung Hyun Kim, Ae Nim Pae, Jin Ri Hong, Jae Kyun Lee
  • Publication number: 20150329533
    Abstract: Disclosed herein are an N-(pyrazolylmethyl)arylsulfonamide derivative useful as a calcium ion channel blocker, a pharmaceutically acceptable salt thereof, and the medicinal use thereof as a therapeutic agent using its calcium ion channel blocking effect.
    Type: Application
    Filed: February 26, 2015
    Publication date: November 19, 2015
    Inventors: Ghil Soo NAM, Kyung Il CHOI, Jung Hyun KIM, Ae Nim PAE, Jin Ri HONG, Jae Kyun LEE
  • Patent number: 9012481
    Abstract: Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: April 21, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Hoh-Gyu Hahn, Kee-Dal Nam, Dong-Yun Shin, Chan-Ho Park, Sung-Woo Cho, Eun-A Kim, Ghil-Soo Nam, Kyung-Il Chol, Seon-Hee Seo, Hee-Sup Shin, Dong-Jin Kim, Ae-Nim Pae, Hye-Jin Chung, Hyun-Ah Choo, Hye-Whon Rhim, Yong-Seo Cho, Eun-Joo Roh, Gyo-Chang Keum, Kee-Hyun Choi, Kye-Jung Shin, Chan-Seong Cheong, Jae-Kyun Lee, Yong-Koo Kang, Young-Soo Kim, Woong-Seo Park, Key-Sun Kim, He-Sson Chung, Chi-Man Song, Sun-Joon Min, Eunice Eun-Kyeong Kim, Cheol-Ju Lee, Soon-Bang Kang
  • Patent number: 8993766
    Abstract: The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an Aza-Prins cyclization reaction in the presence of an oxidant and an oxidation reaction.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 31, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Sun Joon Min, Yong Seo Cho, Jae Kyun Lee, Ae Nim Pae, Young Wook Son
  • Patent number: 8946431
    Abstract: Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: February 3, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Sun Joon Min, Yong Seo Cho, Ae Nim Pae, Eun Jeong Lim, Ji Yeong Kim, Myung Hee Son, Jae Kyun Lee
  • Patent number: 8895602
    Abstract: The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: November 25, 2014
    Assignee: Korea Institute of Science and Technology
    Inventors: Ghil Soo Nam, Kyung Il Choi, Ae Nim Pae, Seon Hee Seo, Hyun Ah Choo, Gyo Chang Keum, Jung Hyun Kim
  • Patent number: 8895558
    Abstract: The present invention relates to novel arylpiperazine-containing pyrrole 3-carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof which is useful for preventing or treating depressive disorders. The present invention also provides a method for preparing the arylpiperazine-containing pyrrole 3-carboxamide derivatives or the pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating depressive disorders.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: November 25, 2014
    Assignee: Green Cross Corporation
    Inventors: Jinhwa Lee, Suk Youn Kang, Eun-Jung Park, Kwang-Seop Song, Min Ju Kim, Hee Jeong Seo, Suk Ho Lee, Jeongmin Kim, Ae Nim Pae, Woo-Kyu Park
  • Publication number: 20140343295
    Abstract: The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.
    Type: Application
    Filed: August 29, 2013
    Publication date: November 20, 2014
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ghil Soo NAM, Kyung Il CHOI, Ae Nim PAE, Seon Hee SEO, Hyun Ah CHOO, Gyo Chang KEUM, Jung Hyun KIM
  • Patent number: 8835436
    Abstract: A novel arylpiperazine-containing imidazole 4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a depressive disorder are provided.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: September 16, 2014
    Assignee: Green Cross Corporation
    Inventors: Jinhwa Lee, Hee Jeong Seo, Suk Youn Kang, Eun-Jung Park, Min Ju Kim, Suk Ho Lee, Jong Yup Kim, Jeongmin Kim, Myung Eun Jung, Hyun Jung Kim, Mi-soon Kim, Ho Kyun Han, Kwang Woo Ahn, Min Woo Lee, Ki-Nam Lee, Ae Nim Pae, Woo-Kyu Park
  • Publication number: 20140206876
    Abstract: Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).
    Type: Application
    Filed: July 16, 2013
    Publication date: July 24, 2014
    Inventors: Sun Joon MIN, Yong Seo CHO, Ae Nim PAE, Eun Jeong LIM, Ji Yeong KIM, Myung Hee SON, Jae Kyun LEE
  • Patent number: 8785453
    Abstract: A novel arylpiperazine-containing purine derivatives and a pharmaceutical composition comprising the same as an active ingredient, which are useful for preventing or treating depressive disorders, are provided.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: July 22, 2014
    Assignee: Green Cross Corporation
    Inventors: Jinhwa Lee, Eun-Jung Park, Suk Youn Kang, Younggyu Kong, Junwon Lee, Hyun Jung Kim, Myung Eun Jung, Ki-Nam Lee, Jeongmin Kim, Ae Nim Pae, Woo-Kyu Park
  • Patent number: 8748422
    Abstract: The present invention relates to a pharmaceutical composition containing one or more quinazoline compounds as an active ingredient, which has antagonistic activity against serotonin 5-HT3A and is effective for the prevention and treatment of central nervous system (CNS) diseases, including emesis, nausea, alcoholism, drug abuse, depression, compulsive neurosis, anxiety, seizure, Alzheimer's disease, Parkinson's disease, Huntington's chorea, psychosis, schizophrenia, suicidal tendency, sleep disorder, appetite disorder and migraine.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: June 10, 2014
    Assignee: Korea Institute of Science and Technology
    Inventors: Ghil Soo Nam, Hye Whon Rhim, Ae Nim Pae, Hyun Ah Choo, Kyung Il Choi, Seung Yeol Nah
  • Publication number: 20140114067
    Abstract: Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.
    Type: Application
    Filed: October 8, 2013
    Publication date: April 24, 2014
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ae Nim PAE, Sun Joon MIN, Eun Joo ROH, Ha Yun YANG, Tae Hoon KIM, Beoung Gun PARK, Yong Seo CHO
  • Patent number: 8507540
    Abstract: The present invention relates to oxazolidinone derivatives containing new bicyclic group, having antibacterial activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, an antibacterial composition comprising the oxazolidinone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a method for treating an infectious disease caused by pathogen using the same. The oxazolidinone derivative or a pharmaceutically acceptable salt thereof may exhibit excellent antibacterial activity against gram positive bacteria including various resistant strains.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: August 13, 2013
    Assignee: Korean Institute of Science and Technology
    Inventors: Gyo-Chang Keum, Eunice Eun-Kyeong Kim, Ae-Nim Pae, Kyung-Il Choi, Soon-Bang Kang, Seon-Hee Seo, Deepak Bhattaral, Ju-Hyeon Lee
  • Publication number: 20130197227
    Abstract: The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an Aza-Prins cyclization reaction in the presence of an oxidant and an oxidation reaction.
    Type: Application
    Filed: September 14, 2012
    Publication date: August 1, 2013
    Applicant: Korea Institute of Science and Technology
    Inventors: Sun Joon MIN, Yong Seo Cho, Jae Kyun Lee, Ae Nim Pae, Young Wook Son
  • Patent number: 8492384
    Abstract: Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: July 23, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Kyung Il Choi, Ghilsoo Nam, Hye Ran Kim, Hyewhon Rhim, Seon Hee Seo, Yoon Jee Kim, Hee Sup Shin, Dong Jin Kim, Ae Nim Pae, Hye Jin Chung, Yong Seo Cho, Hyunah Choo, Eun Joo Roh, Soon Bang Kang, Kye Jung Shin, Hoh Gyu Hahn, Dong Yun Shin, Chan Seong Cheong, Kee Dal Nam, Yong Koo Kang, Jae Kyun Lee, Woong Seo Park, Youngsoo Kim, Eunice Eun-Kyeong Kim, Key-Sun Kim, Hesson Chung, Gyo Chang Keum, Cheolju Lee, Kee Hyun Choi
  • Patent number: 8383631
    Abstract: Provided are a novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound, a pharmaceutically acceptable salt compound thereof, a method for preparing the compound, and an anticancer pharmaceutical composition including the compound as an effective ingredient.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: February 26, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Ghilsoo Nam, Ae Nim Pae, Kyung Il Choi, Hyunah Choo, Vani Nelamane Devegowda, Seon Hee Seo