Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Embodiments of such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5a, R5b, X and Y, are defined herein.

Abstract: The disclosure provides a calibration method, a system and a device of an on-wafer S parameter of a vector network analyzer. The method comprises the steps of: acquiring a first parameter of a first crosstalk calibration piece measured by the vector network analyzer; obtaining a main crosstalk error term based on the first parameter of the first crosstalk calibration piece and a calibration parameter of the first crosstalk calibration piece; acquiring a second parameter of a second crosstalk calibration piece measured by the vector network analyzer based on the main crosstalk error term; and obtaining a secondary crosstalk error term based on the second parameter of the second crosstalk calibration piece and a calibration parameter of the second crosstalk calibration piece, wherein the main crosstalk error term and the secondary crosstalk error term are used for calibrating the vector network analyzer.

Abstract: Methods and apparatus for milling a window for a lateral wellbore in a casing string. An example method introduces a milling assembly into a primary wellbore, the milling assembly comprising: a whipstock, a guide bar coupled to the whipstock, and a wash pipe coupled to the guide bar. The method further includes running the milling assembly to a depth at which it is adjacent to the window in the casing string; securing the whipstock in the casing string; decoupling the wash pipe from the guide bar; guiding the wash pipe to mill the guide bar without milling the whipstock; and milling the window in the casing string with the wash pipe.

Abstract: The present disclosure relates to a novel in vitro dissolution method to assess the release of a bioactive agent from an intracutaneous microneedle system wherein the bioactive agent is coated on or integral to the microneedles. The present disclosure further relates to a novel sample holder clip assembly specially adapted for use with microneedle arrays and patches.

Abstract: Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products.

Abstract: The present invention relates to an inbuilt seat leg support and a seat. The seat leg support is mounted in a seat. The seat includes a base frame and a cushion frame located above the base frame. A receiving space is formed between the base frame and the cushion frame. The seat leg support includes a leg support frame configured to be received in the receiving space. The leg support frame is movable and adjustable relative to the cushion frame. Movement and adjustment of the leg support frame cause the leg support frame to extend out of the receiving space to be in an extended state or to retract into the receiving space to be in a received state. According to the present invention, a receiving space for a leg support frame is reserved between a base frame and a cushion frame, and the leg support frame is disposed to be movable so that the leg support frame can be received in the receiving space when not in use. Receiving a leg support in a seat causes the present invention to be space-saving.

Abstract: A use of a substance for inhibiting SOAT1 gene expression and/or protein activity. The use is selected from at least one of: (a) Preparation of kits for liver cancer diagnosis; (b) Preparation of kits for liver cancer prognosis; (c) Preparation of companion diagnostic kits for treatment of liver cancer; (d) For the preparation of drugs for the prevention and/or treatment of cancer; (e) For the preparation of drugs for the prevention and/treatment of cancer spread and metastasis; (f) For the preparation of drugs that promote the apoptosis of cancer cells; (g) For the preparation of drugs for inhibiting cancer cell formation; (h) For the preparation of drugs that inhibit the proliferation and growth of cancer cells in vitro. Experiments have shown that SOAT1 is highly expressed in liver cancer tissues and serum, and its high abundance indicates poor prognosis of liver cancer patients.

Abstract: The invention provides recombinant DNA molecules that are unique to the maize MON 87419 event and transgenic maize plants, plant parts, seeds, cells, and agricultural products containing the MON 87419 event as well as methods of using and detecting the maize MON 87419 event. Transgenic maize plants containing the MON 87419 event exhibit tolerance to dicamba and glufosinate herbicides.

Abstract: The present application is applicable to the technical field of terahertz on-wafer measurement, and provides a new on-wafer S-parameter calibration method and device. The method includes: performing two-port calibration on a waveguide end face when a probe is not connected to a test system; performing one-port calibration on each of two probe end faces when the probe is connected to the test system; and fabricating a crosstalk calibration standard equal to a device under test in length on a substrate of the device under test, and correct a crosstalk error of the test system according to the crosstalk calibration standard. The present application can realize accurate characterization and correction of crosstalk error in a high-frequency on-wafer S-parameter calibration process, and improve the accuracy of error correction in high-frequency on-wafer S-parameter measurement.

Abstract: Methods and apparatus for milling a window for a lateral wellbore in a casing string. An example method introduces a milling assembly into a primary wellbore, the milling assembly comprising: a whipstock, a guide bar coupled to the whipstock, and a wash pipe coupled to the guide bar. The method further includes running the milling assembly to a depth at which it is adjacent to the window in the casing string; securing the whipstock in the casing string; decoupling the wash pipe from the guide bar; guiding the wash pipe to mill the guide bar without milling the whipstock; and milling the window in the casing string with the wash pipe.

Abstract: The present disclosure provides an electronic device. The electronic device includes a body and a display screen. The display screen is fixed to the body. A back of the body includes a spacing area not covered by the display screen, the spacing area including a conductor layer. The electronic device further includes an antenna of the electronic device disposed in the spacing area to emit or receive radio frequency signals. The antenna includes the conductor layer.

Abstract: A system and method to protect downhole tools and equipment used in transporting fluids with erosional and/or corrosive characteristics is disclosed according to one or more embodiments. The protection assembly engages with a latch coupling or other surface in need of protection to form a barrier between the latch coupling surface and any erosional or corrosive fluids. The protection assembly comprises a barrier sleeve portion and a support sleeve portion disposed in the barrier sleeve. The support sleeve is moveable between a first and second position within the barrier sleeve. In a first position of the support sleeve, collet fingers in the barrier sleeve may flex to allow movement through the latch coupling while in a second position of the support sleeve, the collet fingers may not flex and the barrier sleeve is engaged and protecting the latch coupling.

Abstract: The present disclosure relates to relates generally to metal alloys. The present disclosure relates more particularly to High Entropy Alloys having relatively high strength and relatively low weight. In one aspect, the present disclosure provides a multiple-principal-element high-entropy AlCrTiV metal alloy comprising Al in an amount of 5-50 at %; Cr in an amount of 5-50 at %; Ti in an amount of 5-60 at %; and V in an amount of 5-50 at %, wherein the total amount of Al, Cr, Ti and V is at least 80 at %.

Abstract: A display panel and a method of manufacturing the same are provided. The display pane includes an array substrate and a color filter substrate disposed opposite to each other, and a liquid crystal layer disposed between the array substrate and the color filter substrate. The array substrate includes a transparent electrode layer. The transparent electrode layer includes a pixel electrode and a data line black matrix less (DBS) electrode spaced with each other, a height of the DBS electrode is 0 to 1 micrometer lower than a height of the pixel electrode.

Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.

Abstract: An LED splicing display panel includes at least one repeat unit. Each of the repeat unit includes four sub-LED display panels spliced to each other. Each of the sub-LED display panels includes a display region and fan-out regions. A plurality of slits are between two adjacent sub-LED display panels. The two adjacent sub-LED display panels share the plurality of fan-out regions. The plurality of sub-pixels in the four display regions include a plurality of irregular-shaped sub-pixels and a plurality of regular-shaped sub-pixels. Each of the plurality of irregular-shaped sub-pixels abuts to the corresponding fan-out region.

Abstract: A system for providing entertainment on a vehicle for passengers is described. The system includes (a) a server storing media files and corresponding media keys and (b) monitors storing subsets of the media files and the corresponding media keys. The system includes a server disposed on the vehicle to store the media files and the media keys for the vehicle; monitors disposed on the vehicle to present media selections to passengers corresponding to the media files stored by the server, locally, or on other monitors disposed on the vehicle, and receive an input from a passenger for playing one of the selections. The system also includes selectively revoking the media keys on the server or the monitors. Program logic executed by the server and the monitors implements secure, digital rights management processes as they pertain to the media files presented on the vehicle.

Abstract: The disclosure provides the construction and use of tandem epitope polypeptide of outer membrane protein of campylobacter jejuni, gene, recombinant, plasmid recombinant bacteria, belonging to the technical field of genetic engineering vaccines. The tandem epitope polypeptide of outer membrane protein of campylobacter jejuni can activate the immune response of mice, and has the effect of efficiently preventing Campylobacter jejuni colonization. The tandem epitope polypeptide of the disclosure can be used for preparing vaccines for preventing campylobacter jejuni infection.