Abstract: Methods and systems for managing operation of endpoint devices are disclosed. To manage the operation of endpoint devices, a management framework may be used. The management framework may allow users to define desired outcomes for operation of endpoint devices. Once defined, the management framework may supplement the desired outcomes with additional context. The desired outcomes and additional context may be used to determine how to configure the endpoint devices. For example, applications for deployment to the endpoint devices may be identified and confirmed with the requestors via use of the management framework.

Abstract: A method for managing applications includes obtaining an application resolution report from an administrative system, wherein the application resolution report comprises a customer query and a response, applying a neural network algorithm on a set of tokens associated with the application resolution report to obtain a vector representation of the application resolution report, performing a probability analysis on each vector in the vector representation, based on the probability analysis, identifying an unanswered portion of the application resolution report, and in response to the unanswered portion of the application resolution report, performing a query resolution.

Abstract: The present disclosure relates, in part, to compounds, compositions, and methods for treatment, ameliorating, and/or prevention of certain neurodegenerative diseases and/or cancers.

Abstract: Provided are multilayer films including ethylene-based polymers. The multilayer films can be fully compatible with polyethylene recycling streams. The multilayer films include a first outer layer, a second outer layer, and a core, the core including a first core layer that includes an ethylene-propylene copolymer. The multilayer films of the present invention can exhibit improved, maintained, or desirable properties, such as high tear resistance, in comparison to existing multilayer film structures that are not fully compatible with polyethylene recycling streams.

Abstract: A method for training a machine learning model for categorizing data is provided. The method comprising receiving labeled positive training data and negative training data. The positive training data and negative training data are lemmatized and then vectorizing the lemmatized into a vector space. A machine learning model is trained with the vectorized positive training data and negative training data to identify a new category of data from existing categories in the positive training data and negative training data.

Abstract: A method for performing a plasma etch process is provided. The method initiates with receiving a substrate into a chamber. A high frequency (HF) RF signal is generated, said HF RF signal being pulsed in at least a three-state cycle including a first state, a second state, and a third state. The first state is configured at a first power level; the second state is configured at a second power level less than the first power level; and, the third state is configured at a third power level less than the second power level. The second power level of the HF RF signal being in the range of about 0 W to 3500 W. The HF RF signal is applied to an electrode of the chamber for performing the plasma etch process.

Abstract: A breath-enhanced nebulizer adapted for use in administering an aerosolized pharmaceutical composition to a patient by inhalation wherein the patient is connected to a mechanical ventilator is disclosed. The nebulizer has a Venturi driven by a nebulizer air supply that draws a solution of a pharmaceutical composition into a shear zone where the solution is atomized. The Venturi effect is amplified by the internal configuration of the nebulizer to increase the rate of nebulization of drug. Optionally, breath-actuated nebulization is used, employing a pressure sensor interposed between the nebulizer and mechanical ventilator that controls the nebulizer air supply, such that nebulizer air and concomitant nebulization only occurs during the inhalation phase of a breathing cycle.

Abstract: This disclosure relates generally to a method and system for predicting safe time of operation for a rotary kiln. Over the period of time, the rotary kiln develops a ring within the inner walls of the kiln and suffers sudden shut down due to choking of the kiln. State-of-the-art methods provide the various methods of predicting safe time of operation, but the prediction is based on limited features and hence suffers accuracy. The disclosed method predicts safe time of operation for a rotary kiln based on mathematical model that estimates size of ring by estimating plurality of derived parameters based on operational parameters and design parameters. The derived parameters are the estimations provided by a solid bed height variation model, a gas stream model, a solid stream, a melt model, an agglomeration model, a volatile model, and a ring formation model.

Abstract: An embodiment for synchronization of physical delivery with a metaverse activity is provided. The embodiment may include receiving real-time and historical data relating to a metaverse activity. The embodiment may also include identifying a context of the metaverse activity. The embodiment may further include in response to determining at least one user requires physical delivery of one or more physical objects, identifying a time at which the at least one user requires the physical delivery of the one or more physical objects during the metaverse activity. The embodiment may also include causing at least one robotic device to onboard the one or more physical objects to be delivered in advance of the required time. The embodiment may further include deploying the at least one robotic device to deliver the onboarded one or more physical objects to a physical location of the at least one user at the required time.

Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells with a combination of antibodies specific for CD117, and agents that modulate immunoregulatory signaling pathways, e.g. agonists of immune costimulatory molecules, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment, even in immunocompetent recipients.

Abstract: An embodiment for synchronization of physical delivery with a metaverse activity is provided. The embodiment may include receiving real-time and historical data relating to a metaverse activity. The embodiment may also include identifying a context of the metaverse activity. The embodiment may further include in response to determining at least one user requires physical delivery of one or more physical objects, identifying a time at which the at least one user requires the physical delivery of the one or more physical objects during the metaverse activity. The embodiment may also include causing at least one robotic device to onboard the one or more physical objects to be delivered in advance of the required time. The embodiment may further include deploying the at least one robotic device to deliver the onboarded one or more physical objects to a physical location of the at least one user at the required time.

Abstract: A computer-implemented method for authenticating an individual to one or more IoT devices. The method may include: receiving active behavioral data from the personal electronic device; retrieving an active behavioral profile corresponding to the individual; comparing the active behavioral data with the active behavioral profile; and authenticating the individual based at least in part on the comparison.

Abstract: Electronic devices including a textured component such as a cover member positioned over one or more components of the electronic device. Different surface regions of the textured component may be textured differently in order to provide optical contrast. For example, differently textured surface regions may differ in gloss, translucency, or both. In some cases the cover member defines a protruding feature and a surface region of the protruding feature is textured differently than an adjacent surface region.

Abstract: Generally discussed herein are devices, systems, and methods for calibration of a gaze indicator. A method can include receiving gaze tracker output data that indicates a gaze location on a display at which a user is gazing, determining an expected gaze location to which the user is expected to gaze after the gaze location, receiving further gaze tracker output data that indicates a subsequent gaze location on the display at which the user is gazing, and adjusting, based on the subsequent gaze location and the expected gaze location, a location of a visual gaze indicator on the display.

Abstract: Provided are multilayer films including ethylene-based polymers. The multilayer films can be fully compatible with polyethylene recycling streams. The multilayer films include a first outer layer, a second outer layer, and a core, the core including a first core layer that includes an ethyl ene-propylene copolymer. The multilayer films of the present invention can exhibit improved, maintained, or desirable properties, such as high tear resistance, in comparison to existing multilayer film structures that are not fully compatible with polyethylene recycling streams.

Abstract: Provided are multilayer films including ethylene-based polymers. The multilayer films can be fully compatible with polyethylene recycling streams. The multilayer films comprise a first outer layer, a second outer layer, and a core, the core including a first core layer that includes an ethylene-propylene copolymer. The multilayer films of the present invention can exhibit improved, maintained, or desirable properties, such as high tear resistance, in comparison to existing multilayer film structures that are not fully compatible with polyethylene recycling streams.

Abstract: A method, system, and computer program product for management of large multi-database installations. The method form commences by analyzing a multiple database installation to determine a set of candidate upgrade operations to apply to individual instances of heterogeneous databases in the multiple database installation, and then scheduling an order in which order to apply individual operations from among the set of candidate upgrade operations. In exemplary operation, the candidate upgrade operations comprise database version upgrades, database stack upgrades, and/or database listener upgrades. Some embodiments exploit homogeneity and/or groupings in order to parallelize performance of various upgrade operations during mass upgrade of multi-database installations. In addition to performing upgrade operations in the form of database version upgrades, database stack upgrades, and/or database listener upgrades, the installation can be upgraded by receiving application upgrades.

Abstract: The disclosure is generally directed to spherical nucleic acids (SNAs), nanostructures with a core surrounded by a radial presentation of oligonucleotides, that can activate a cytoplasmic DNA sensor including but not limited to cyclic GMP-AMP synthase (cGAS). In some embodiments, the SNAs also inactivate a transcription factor including but not limited to signal transducer and activator of transcription 3 (STATS). Methods of making and using the SNAs are also provided herein. In some aspects, the present disclosure provides a spherical nucleic acid (SNA) comprising (a) a nanoparticle core; and (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising a double-stranded or single-stranded stem loop DNA oligonucleotide that activates cyclic GMP-AMP synthase (cGAS) and is at least 15 base pairs in length.

Abstract: The present application provides methods and systems for detecting and quantifying chromosomal instability from histology images with machine-learning. Also described herein are methods for selecting treatments for a medical disease, by determining a chromosomal instability metric from histology images. The disclosed methods and systems may also be used to investigate disease progression and prognosis.

Abstract: Provided are methods for creating a diagnostic model for determining a disease of a subject, methods to identify disease-associated metaepigenomic biomarkers and methods to employ these biomarkers to accurately diagnose certain diseases from a tissue or liquid biopsy sample, based on epigenetic data from the subject's genome and microbial genomes contained within that subject