Abstract: The present invention is related to a preparation for use in therapy, wherein therapy comprises local administration of the preparation to a subject, wherein the local administration is selected from the group consisting of intramuscular administration, subcutaneous administration, intravitreal administration, intrathecal administration, intratumoral administration, intracerebral administration and intradermal administration, wherein the preparation comprises lipid nanoparticles, wherein the lipid nanoparticles comprise a lipid composition comprising a first and a second lipid, and a therapeutically active nucleic acid molecule, and, wherein the lipid nanoparticles are amphoteric, overall neutrally charged lipid nanoparticles.

Abstract: A computer-implemented method for authenticating an individual to one or more IoT devices. The method may include: receiving active behavioral data from the personal electronic device; retrieving an active behavioral profile corresponding to the individual; comparing the active behavioral data with the active behavioral profile; and authenticating the individual based at least in part on the comparison.

Abstract: Methods are provided for targeting cells for depletion, including without limitation tumor cells, in a regimen comprising contacting the targeted cells with a combination of agents that modulate immunoregulatory signaling. Immunoregulatory modulating agents include (i) an agent that blockades CD47 activity; and (ii) an agent that agonizes an immune costimulatory molecule, e.g. CD137. The regimen may further comprise an agent that specifically binds to the target cell, e.g. an antibody or biologically active fragment or derivative thereof. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single immunoregulatory modulating agent is used; and the effect may be synergistic relative to a regimen in which a single immunoregulatory modulating agent is used.

Abstract: A geographically distributed data store including a number of geographically distributed regions may be implemented using replication groups that include multiple regions configured according to replication criteria. First tier replication of particular changes to data stored in the distributed data store may be performed in compliance with the replication criteria, where management of replication state is performed with respect to replication across the replication groups. Independent of the first tier replication, individual replication groups may implement second tier replication of changes to data where management of replication state is performed with respect to replication within the particular replication group. Replication group configuration may be determined using the replication criteria which may include thresholds for replication resource utilization, replication latency and utilization of data change logs.

Abstract: Embodiments of the present disclosure are directed to post-consumer recycled (PCR) resin formulations comprising: PCR resin comprising a blend of polyethylene recovered from post-consumer material, pre-consumer material, or combinations thereof; and virgin polyethylene resin formulation, wherein the virgin polyethylene resin formulation comprises: a density from 0.910 to 0.950 g/cc, an improved comonomer content distribution (iCCD) wt. fraction greater than 30 wt. % at a temperature range of 35 to 90° C., and an iCCD wt. fraction greater than 8 wt. % at a temperature range of 99 to 115° C. The PCR resin formulation comprises an overall density of from 0.910 to 0.930 g/cc; an iCCD second elution peak occurring at a temperature greater than 99° C.; an iCCD wt. fraction greater than 6 wt. % at a temperature range of 99 to 115° C.; and an iCCD wt. fraction greater than 60 wt. % at a temperature range of 35 to 90° C.

Abstract: Systems and processes for operating a digital assistant are provided. An example method for processing an image include receiving an image, generating, based on the image, a question corresponding to a first object in the image, generating, based on the image, a caption corresponding to a second object of the image, receiving an utterance from a user, and determining a plurality of speech recognition results from the utterance based on the question and the caption.

Abstract: A first natural language understanding (NLU) model associated with a first language is obtained. A second natural language understanding model associated with a second language different from the first language is obtained. The second NLU model is functionally consistent with the first NLU model. A change to a functionality of the first NLU model is detected. In response to detecting the change to the functionality of the first NLU model, the change is automatically propagated to the second NLU model.

Abstract: Methods, systems, and computer programs are presented for generating a question for a group and prompting the user to post that question. One method includes determining, for one or more groups of a user network, at least one group skill associated with the groups. A prompt is generated based on one or more user skills of a first user, including inserting at least one user skill into a prompt template to generate the prompt, where the prompt template includes a request to generate questions for the respective group. The prompt is provided as input into a generative artificial intelligence (GAI) model, a question is selected from the output of the GAI model, and a group is selected for based on the user skill inserted into the prompt template and the group skills associated with the groups. The selected question and the selected group are presented on a user interface.

Abstract: Disclosed is a curly fiber having a fiber centroid and comprising a first region having a first centroid and a second region wherein the first region comprises an ethylene/alpha olefin interpolymer composition in an amount of at least 75 weight percent based on total weight of the first region and wherein the ethylene/alpha olefin interpolymer composition is characterized by a low temperature peak and a high temperature peak on an elution profile via improved comonomer composition distribution (ICCD) procedure, and a full width at half maximum of the high temperature peak is less than 6.0° C. and the second region is a material comprising a polymer which is different from the ethylene/alpha-olefin interpolymer of the first region and wherein the regions are arranged such that at least one of the first centroid and the second centroid is not the same as the fiber centroid.

Abstract: Provided are bicomponent fibers with curvature. The bicomponent fiber includes a first region and a second region. The first region includes a polypropylene blend and second region includes an ethylene/alpha-olefin interpolymer composition. The polypropylene blend includes a polypropylene homopolymer and a propylene-ethylene interpolymer, wherein the propylene-ethylene interpolymer has a density of from 0.860 to 0.880 g/cc and a melt flow rate of greater than 12 g/10 min. The ethylene/alpha-olefin interpolymer composition has a density of greater than 0.920 g/cc and a melt index (I2) of from 10 to 25 g/10 min. The bicomponent fiber can be used to form a nonwoven.

Abstract: In some aspects, a method includes storing a configuration database at a media platform. The configuration database includes base customization data associated with the media platform and manufacturer customization data associated with a plurality of manufacturers of television devices. The method includes receiving a configuration request from a television device, where the configuration request includes a location and/or a device identifier of the television device. The method includes selecting a portion of the manufacturer customization data that correspond to the location and/or the device identifier of the television device, generating server-based customization data for the television device based on the portion of the manufacturer customization data and the base customization data, and transmitting the server-based customization data to the television device, where the server-based customization data is configured to be used by the television device to customize a user interface of the media platform.

Abstract: A trained machine learning algorithm processes time series production data. The time series production data are representative of a control process within a facility control loop. The machine learning training algorithm is trained using positive training data that are representative of a normal operation of components within the facility control loop and negative training data that are representative of an abnormal operation of components within the facility control loop. Output of the trained machine learning algorithm identifies abnormalities in the facility control loop.

Abstract: Systems and processes for operating a digital assistant are provided. An example method for processing an image include receiving an image, generating, based on the image, a question corresponding to a first object in the image, generating, based on the image, a caption corresponding to a second object of the image, receiving an utterance from a user, and determining a plurality of speech recognition results from the utterance based on the question and the caption.

Abstract: A specification of a first natural language understanding (NLU) machine learning model for a first human communication language is received. The specification specifies a language content associated with one or more intents of the first NLU machine learning model in the first human communication language. An identification of an association between the first NLU machine learning model and a second NLU machine learning model for a second human communication language is received. The first NLU machine learning model and the second NLU machine learning model are managed together. This includes detecting a change to the first NLU machine learning model in the first human communication language and a software using the first NLU and in response automatically assisting in maintaining consistency in the second NLU machine learning model in the second human communication language by respectively updating the software with respect to the detected change.

Abstract: Methods are provided for targeting cells for depletion, including without limitation tumor cells, in a regimen comprising contacting the targeted cells with a combination of agents that modulate immunoregulatory signaling. Immunoregulatory modulating agents include (i) an agent that blockades CD47 activity; and (ii) an agent that agonizes an immune costimulatory molecule, e.g. CD137. The regimen may further comprise an agent that specifically binds to the target cell, e.g. an antibody or biologically active fragment or derivative thereof. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single immunoregulatory modulating agent is used; and the effect may be synergistic relative to a regimen in which a single immunoregulatory modulating agent is used.

Abstract: A method, a system and an electronic device are disclosed herein for providing a controlled transmission of a content pack from a primary electronic device 104 to the electronic device being used by a child. The primary electronic device 104 is configured to operate, via a server 108 in a communication network 106, a content delivery module 110 for delivering at least one part of the content pack. The electronic device is configured to receive the at least one part of the content pack from the primary electronic device 104, wherein the at least one part of the content pack is pre-selected from the content pack by a user associated with the primary electronic device 104.

Abstract: A valved holding chamber is provided for the administration of drugs to a patient by inhalation from a metered dose inhaler having an exhalation filter on an exhalation pathway adapted to trapping aerosols and droplets in exhaled air. The exhalation filter may be angled at an approximately 45° angle away from the face of the patient. The exhalation filter prevents transmission of airborne diseases such as COVID-19 or influenza, or drug particles that could be sensitizing agents for caregivers or others in the patient's environment.

Abstract: The system and methods described herein determine whether to override commands to modify content presentation in a multi-user content consumption environment. A media guidance application detects a first and second user consuming content. Upon receiving a command from the first user to modify the presentation of the content, the media guidance application retrieves a user profile of the second user and compares attributes in the user profile to metadata for the segment of the content. Based on the comparison, the media guidance application determines whether to override the command, for example based on a predicted interest level or importance level determined by the comparison. In response to determining to override the command, the media guidance application refrains from executing the command by canceling or delaying the command and generates a notification message to the user with a reason why the command was overridden.

Abstract: Systems and methods are described for determining a second entity having a similar trademark portfolio as a first entity. In embodiments, a user submits a request identifying a first entity. A trademark portfolio generator compiles a trademark portfolio of the first entity by accessing a database of trademarks. A trademark portfolio analyzer analyzes the features of the trademark portfolio to form a trademark portfolio profile. A portfolio similarity score calculator determines a trademark portfolio similarity score based by determining the similarity between the trademark portfolio profile of the first entity and trademark portfolio profiles of the second entity. In embodiments, feature vectors related to trademark portfolio profiles of two or more entities are compared to generate portfolio similarity scores. Based on the portfolio similarity scores, a user interface presents the second entity to the user as an entity having a similar trademark portfolio as the first entity.

Abstract: Embodiments herein provide a system for electrically heated gas mixture mediated industrial plant processes providing a fossil fuel free approach. The system utilizes a gas mixture as heating medium that directly transfers heat to a raw material required for processing the raw material into an end product. The gas mixture used as a heating medium can be a byproduct generated during processing or a combination of stable gases that are reutilized and recirculated to carry heat and dissipate the heat at various stages of processing in accordance with a heating medium design loop. The heating medium design loop disclosed is designed such that it eliminates the need of heat management equipment like a Thermal Energy Storage (TES) system used by existing approaches. Entire heating of the plant is carried out using electric gas heaters heated using renewable electric sources to provide the fossil fuel free design.