Abstract: The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV.

Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.

Abstract: The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV.

Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.

Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.

Abstract: The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV.

Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.

Abstract: The described invention consists of system and the computer methods of generating and manipulating value or gift cards which are cryptographically assigned to a person's identity and stored on double entry ledger called block chain. A functional module of the system allows the transfer of such value or gift cards to other persons. The functional module in the system further allows a person owning a card to split it into multiple value or gift cards, merge more than one value or gift cards to a single card, exchange a value or gift card with a specific merchant card, redeem a value or gift card at a store front in exchange for physical or digital good or cash it out in the currency it was issued. Each transaction associated with a customer is cryptographically signed and stored on the block chain.

Abstract: A highly agile low phase noise frequency synthesizer is provided for rapid generation of frequency specific signals. The frequency synthesizer is capable of rapidly generating signals at different output frequencies while maintaining low cross-coupling. Two or more signal generators utilize a reference frequency to generate two or more signals. These signals are limit processed to reduce cross-coupling prior to being presented to a switch. Responsive to a control signal, the switch outputs one of the signals to a frequency modification device, such as a frequency divider or multiplier. Responsive to a control signal, the frequency modification device scales the frequency of the switch output to convert the frequency of the switch output signal to a desired output frequency. By maintaining sufficient frequency separation between the switch input signals cross-coupling and phase noise is minimized and implementation on an integrated circuit may be achieved.

Abstract: Described herein are systems and methods for collecting and surfacing metrics with respect to their classification; and the use of the metrics by a workload manager and other application monitoring tools to provide quality-of-service and workload management. Each request is classified, either by the application server or another process. A request classification identifier (RCID) is associated with each request, and thereafter flows with that request as it is being processed. The RCID value is used by data collectors at various points in the system to aggregate the metrics, and a workload manager collects the metrics. The collected metrics are then processed by a rules engine at the workload manager, which analyzes the metrics and generates adjustment recommendations to provide quality-of-service and workload management.

Abstract: Described herein are systems and methods for collecting and surfacing metrics with respect to their classification; and the use of the metrics by a workload manager and other application monitoring tools to provide quality-of-service and workload management. Each request is classified, either by the application server or another process. A request classification identifier (RCID) is associated with each request, and thereafter flows with that request as it is being processed. The RCID value is used by data collectors at various points in the system to aggregate the metrics, and a workload manager collects the metrics. The collected metrics are then processed by a rules engine at the workload manager, which analyzes the metrics and generates adjustment recommendations to provide quality-of-service and workload management.

Abstract: Described herein are systems and methods for providing diagnostic information between an application server (e.g., a WebLogic server), and a virtual machine (VM) (e.g., a JRockit VM). In accordance with an embodiment, the system includes a diagnostic monitoring component adapted to obtain diagnostic data indicative of all available data on an application server, including diagnostic information from one or more application server components running on the application server, obtain diagnostic data from the virtual machine, and persists the diagnostic data obtained from the application server and the virtual machine into a diagnostic data image file. The system further includes a console that provides access to the diagnostic data persisted into the diagnostic image file.

Abstract: Described herein are systems and methods for collecting and surfacing metrics with respect to their classification; and the use of the metrics by a workload manager and other application monitoring tools to provide quality-of-service and workload management. Each request is classified, either by the application server or another process. A request classification identifier (RCID) is associated with each request, and thereafter flows with that request as it is being processed. The RCID value is used by data collectors at various points in the system to aggregate the metrics, and a workload manager collects the metrics. The collected metrics are then processed by a rules engine at the workload manager, which analyzes the metrics and generates adjustment recommendations to provide quality-of-service and workload management.

Abstract: Described herein are systems and methods for collecting and surfacing metrics with respect to their classification; and the use of the metrics by a workload manager and other application monitoring tools to provide quality-of-service and workload management. Each request is classified, either by the application server or another process. A request classification identifier (RCID) is associated with each request, and thereafter flows with that request as it is being processed. The RCID value is used by data collectors at various points in the system to aggregate the metrics, and a workload manager collects the metrics. The collected metrics are then processed by a rules engine at the workload manager, which analyzes the metrics and generates adjustment recommendations to provide quality-of-service and workload management.

Abstract: In one embodiment, services are not loaded if they are not needed by the user and if no services needed by the user are dependent upon them. In one embodiment, server services are represented as nodes in a graph data structure. Connections between the nodes indicate dependencies between the server services. The graph is sorted to create an ordered list of services which can be used to startup the services. In another embodiment a server services manager reads license files and user inputs and marks the ordered list of services to indicate which services are to startup.

Abstract: Described herein are systems and methods for providing diagnostic information between an application server (e.g., a WebLogic server), and a virtual machine (VM) (e.g., a JRockit VM). In accordance with an embodiment, the system includes a diagnostic monitoring component adapted to obtain diagnostic data indicative of all available data on an application server, including diagnostic information from one or more application server components running on the application server, obtain diagnostic data from the virtual machine, and persists the diagnostic data obtained from the application server and the virtual machine into a diagnostic data image file. The system further includes a console that provides access to the diagnostic data persisted into the diagnostic image file.

Abstract: Described are novel protease inhibitors and methods for using said protease inhibitors in the treatment of human immunodeficiency virus (HIV) infection.

Abstract: In accordance with embodiments, there are provided mechanisms and methods for providing interoperable management of application servers. These mechanisms and methods can enable a software developer to create client applications using one or more programming systems, i.e., .NET, C++, VISUAL C++, etc. that can discover and interact with management resources, such as objects, functions and so forth, deployed on an application server, such as an application server implemented using a disparate programming system, i.e., a J2EE Application server, for example. Embodiments employing interfaces that conform to an implemented standard, i.e., Web Service Description Language (WSDL), for example and conform to an implemented protocol, such as Simple Object Access Protocol (SOAP), Hyper-Text Transfer Protocol (HTTP) for example, can enable third parties, for example, to create software to monitor managed applications and/or servers.

Abstract: A highly agile low phase noise frequency synthesizer is provided for rapid generation of frequency specific signals. The frequency synthesizer is capable of rapidly generating signals at different output frequencies while maintaining low cross-coupling. Two or more signal generators utilize a reference frequency to generate two or more signals. These signals are limit processed to reduce cross-coupling prior to being presented to a switch. Responsive to a control signal, the switch outputs one of the signals to a frequency modification device, such as a frequency divider or multiplier. Responsive to a control signal, the frequency modification device scales the frequency of the switch output to convert the frequency of the switch output signal to a desired output frequency. By maintaining sufficient frequency separation between the switch input signals cross-coupling and phase noise is minimized and implementation on an integrated circuit may be achieved.

Abstract: The present invention provides compounds and compositions for inhibiting Vif and methods for treating viral infection, e.g., HIV infection.