Abstract: An object of the present invention is to provide a bispecific antibody having an agonist activity to a GM-CSF receptor, and a bispecific antibody fragment thereof. The present invention relates to a bispecific antibody or a bispecific antibody fragment thereof containing: a first antigen-binding domain; and a second antigen-binding domain, in which one of the first antigen-binding domain and the second antigen-binding domain is an antigen-binding domain binding to CD116, and the other one is an antigen-binding domain binding to CD131.

Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.

Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.

Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.

Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.

Abstract: There is provided an applicator that applies a coating liquid onto the upper surface of a web, and an application method which are capable of sufficiently enhancing the evenness of a coating surface. The applicator includes: a bar which rotates while coming into contact with the upper surface of the continuously travelling web via the coating liquid; and a barrier plate which is provided on an upstream side of the bar in a travelling direction of the web and allows the coating liquid to flow in a direction toward the web between the barrier plate and the bar, in which, when a distance between the barrier plate and an end edge portion of the bar, which is closest to the barrier plate, is referred to as A and a distance between the barrier plate and the web is referred to as B, A is 0.5 mm to 5 mm, B is 0.5 mm to 5 mm, and B?A is satisfied.

Abstract: There is provided an applicator that applies a coating liquid onto the upper surface of a web, and an application method which are capable of sufficiently enhancing the evenness of a coating surface. The applicator includes: a bar which rotates while coming into contact with the upper surface of the continuously travelling web via the coating liquid; and a barrier plate which is provided on an upstream side of the bar in a travelling direction of the web and allows the coating liquid to flow in a direction toward the web between the barrier plate and the bar, in which, when a distance between the barrier plate and an end edge portion of the bar, which is closest to the barrier plate, is referred to as A and a distance between the barrier plate and the web is referred to as B, A is 0.5 mm to 5 mm, B is 0.5 mm to 5 mm, and is satisfied.

Abstract: A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as “RAGE”) than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.

Abstract: A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as “RAGE”) than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.

Abstract: A biochemical analysis unit comprises a base plate, which has holes, and a porous adsorptive material, which is filled in each of the holes and forms each of adsorptive regions. Each of the adsorptive regions is provided with a layer, which has pores having a comparatively small mean pore diameter, and a layer, which has pores having a comparatively large mean pore diameter. In cases where the layers, which constitute each of the adsorptive regions, are connected with the layers, which constitute an adjacent adsorptive region, at one of surfaces of the base plate, the biochemical analysis unit further comprises a signal absorbing layer for absorbing a signal, which passes through layers located under the base plate and thus propagates from a certain hole toward an adjacent hole.

Abstract: A continuous substrate and a continuous absorptive sheet are fed to a press station, and pressed continuously or intermittently. Part of the continuous absorptive sheet is charged in plural holes formed in the continuous substrate to form a biochemical analysis sheet. The biochemical analysis sheet is cut into predetermined tips to obtain a biochemical analysis unit.

Abstract: A dope is cast onto a casting drum from a casting die while forming a casting bead. Oxygen concentration at the vicinity of the casting bead is set to 0 vol % or more and less than 10 vol %, and a static electricity applying electrode applies static electricity between the casting drum and the casting bead. An intervening film forming device supplies intervening film forming liquid onto the casting drum to form an intervening film. A compression chamber decompresses a downstream area from the casting bead. Thereby, it is possible to form the casting bead having a stable shape, and enhance the extent of adhesion between a casting film and the casting drum. Accordingly, it is possible to enhance the extent of adhesion between the casting drum and the casting bead, prevent occurrence phenomenon of air entrainment, and speed up a film forming speed, thus forming a polymer film.

Abstract: In producing a biochemical analysis unit (1), an adhesive agent (25) is applied to a base. After calcinations, the adhesive agent (25) forms an adhesive layer (25a, 25b) on a wall of each holes (3) formed in the base (2). Thereafter, an excess adhesive agent (25c) remaining on the surface of the base (2) is removed. Then, a sheet of an absorptive material (4) is set to overlap the base (2). A press roller pair (27, 28) presses them to charge the absorptive material (4) in the holes (3). Thus the absorptive material (4) is fixed in the hole (3) of the base (2) through the adhesive layer (25a, 25b).

Abstract: There is provided a casting drum having an outer peripheral surface provided with an electrical insulating layer. Direct-current high voltage is applied to an electrode bar disposed in an upstream side from a discharge port to discharge toward the casting drum. Bead is attracted to the charged casting drum by electrostatic attraction. Thereby, the adhesion between the bead and the casting drum is increased, and therefore the occurrence of phenomenon of air entrainment can be prevented. A wet film obtained by peeling a casting film from the casting drum is dried. Accordingly, it is possible to produce a film having few defects such as voids and high quality such as excellent smoothness at high speed and stably.

Abstract: A polymer film producing apparatus includes a casting device, having a casting die, for ejecting dope to form a bead, and casting the bead on a support drum traveling continuously to form a cast film, the dope containing polymer, solvent and additive. A dryer dries the cast film stripped from the support drum, to obtain a polymer film. A voltage application device is connected with the support drum, for applying voltage to the support drum during casting of the casting device. Preferably, the support drum is electrically non-grounded, and has a surface coated with an electrical insulation film. A surface potential V of the support drum is in a range of 0.1 kV<|V|<3 kV. A decompression chamber is disposed close to a surface of the support drum, for tightening contact of the bead on the surface of the support drum.

Abstract: A biochemical analysis unit comprises a base plate, which has holes, and a porous adsorptive material, which is filled in each of the holes and forms each of adsorptive regions. Each of the adsorptive regions is provided with a layer, which has pores having a comparatively small mean pore diameter, and a layer, which has pores having a comparatively large mean pore diameter. In cases where the layers, which constitute each of the adsorptive regions, are connected with the layers, which constitute an adjacent adsorptive region, at one of surfaces of the base plate, the biochemical analysis unit further comprises a signal absorbing layer for absorbing a signal, which passes through layers located under the base plate and thus propagates from a certain hole toward an adjacent hole.

Abstract: A biochemical analysis unit comprises a base plate, which has holes, and a porous adsorptive material, which is filled in each of the holes and forms each of adsorptive regions. Each of the adsorptive regions is provided with a layer, which has pores having a comparatively small mean pore diameter, and a layer, which has pores having a comparatively large mean pore diameter. In cases where the layers, which constitute each of the adsorptive regions, are connected with the layers, which constitute an adjacent adsorptive region, at one of surfaces of the base plate, the biochemical analysis unit further comprises a signal absorbing layer for absorbing a signal, which passes through layers located under the base plate and thus propagates from a certain hole toward an adjacent hole.

Abstract: The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.

Abstract: The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.

Abstract: A dope is produced from TAC and a mixture solvent whose main compound is dichloromethane. The dope is cast from a casting die onto a casting drum. In an upstream side from the casting die, a decompression chamber having air pipes is provided. The difference from the ordinate pressure to the pressure inside the decompression chamber is ?2000 Pa to ?10 Pa. An air is fed through the air pipes into the decompression chamber. Thus the pressure fluctuation in the decompression chamber is reduced, and the pressure becomes almost constant in the widthwise direction. Therefore, the entrained air and another air are prevented from entering into the decompression chamber, which makes the shape of the bead of the discharged casting dope stable. When having self-supporting properties, the casting film is peeled as a film from the casting drum and dried to be a TAC film without thickness unevenness.