Abstract: The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which induces production of memory CD4 T cells allows for the access of a therapeutic antibody to the immunoprivileged tissue.

Abstract: A network controller is configured to perform, to a new slice request, resource allocation from a resource of unallocated resource information managed by a resource information management unit, and to reallocate the resource to an existing slice request so that an unallocated resource increases based on unallocated resource information managed by the resource information management unit.

Abstract: The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which induces production of memory CD4 T cells allows for the access of a therapeutic antibody to the immunoprivileged tissue.

Abstract: The present invention provides combination therapies that are useful for treating and/or preventing certain cancers. In certain embodiments, the therapy comprises an immune-checkpoint inhibitor and a RIG-I agonist. In other embodiments, the therapy comprises a RIG-I agonist.

Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5?-triphosphate or a 5?-diphosphate.

Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5? triphosphate or a 5? diphosphate.

Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5? triphosphate or a 5? diphosphate.

Abstract: The present invention provides combination therapies that are useful for treating and/or preventing certain cancers. In certain embodiments, the therapy comprises an immune-checkpoint inhibitor and a RIG-I agonist. In other embodiments, the therapy comprises a RIG-I agonist.

Abstract: The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which induces production of memory CD4 T cells allows for the access of a therapeutic antibody to the immunoprivileged tissue.

Abstract: The present invention relates to a vaccination strategy that establishes protective immunity, including a protective memory T-cell population.

Abstract: A thermosensitive recording material having a high thermosensitivity and useful for recording thereon colored images having high storage persistency, comprises a thermosensitive colored image-forming layer formed on a surface of a substrate sheet and comprising a colorless dye precursor; a color-developing aromatic compound having, per molecule thereof, at least one arylsulfonylureido group of the formula (I): ##STR1## wherein R.sup.1 =aromatic group unsubstituted or substituted with at least one of lower alkyl and lower alkoxyl group and hologen atoms; a sensitizing aromatic amide compound of the formula (II): ##STR2## wherein Ar.sup.1, Ar.sup.2 =non-substituted phenyl or naphthyl group or substituted phenyl or naphthyl group with 1 to 3 substituent selected from aryl, aryloxy, aralkyl, alkyl, alkoxyl, trihalogenomethyl, nitro and alkylamino groups and halogen atoms; and a binder.

Abstract: A thermosensitive recording material for recording thereon clear colored images having an excellent storage persistency over a long time, comprises a thermosensitive colored image-forming layer formed on a substrate and comprising a colorless dye precursor, a binder and a color developing agent comprising at least one compound having at least one group of the formula (I): ##STR1## wherein R = unsubstituted aromatic group or substituted aromatic group having at least one substituent selected from alkyl, alkoxyl and halogen, and the thermosensitive colored image-forming layer further comprises an additive comprising at least one member selected from the compounds of the formulae (II) and (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 = alkyl, alkoxyl, aralkyl, aryl, aryloxy, nitro, acetylamino, acetoacetylamino, halogen or hydrogen; and Ar.sub.1, Ar.sub.

Abstract: A thermosensitive recording material capable of recording thereon colored images having high resistances to oily substances, plasticizers, moisture, and heat and an excellent storage persistency over a long time, comprises a thermosensitive colored image-forming layer formed on a sheet substrate and comprising a colorless dye precursor, a color developing agent, and a binder, the color developing agent comprising at least one compound of the formula (I): ##STR1## wherein X is an O or S atom, R is an unsubstituted aromatic group or an aromatic group substituted by a lower alkyl or halogen atom; A represents a multivalent group, and n is an integer of 2 or more.

Abstract: A thermosensitive recording material capable of recording thereon colored images having high resistances to oily substances, plasticizers, moisture, and heat and an excellent storage persistency over a long time, comprises a thermosensitive colored image-forming layer formed on a sheet substrate and comprising a colorless dye precursor, a color developing agent, and a binder, the color developing agent comprising at least one compound of the formula (I): ##STR1## wherein X is an O or S atom, R.sup.1 is an unsaturated aromatic group or a substituted phenyl group having a lower alkyl or halogen atom and R.sup.2 and R.sup.3 are respectively a hydrogen atom, alkyl, aralkyl, substituted alkyl having an aryloxy, unsubstituted aromatic group, or substituted aromatic group having at least one substituent selected from alkyl, aryl, aralkyl, alkyloxy, alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, and arylsulfonyl groups, and halogen atoms.

Abstract: A heat-sensitive recording material with an excellent recording sensitivity and capable of recording thereon high quality images at a high recording speed, comprising a heat-sensitive color-forming layer formed on a substrate sheet and comprising a colorless dye precursor, a color-developing agent, a binder and a sensitizing agent consisting essentially of 1,2-diphenoxybenzene.

Abstract: A heat-sensitive recording material with an excellent recording sensitivity, heat stability and resistance to the whitening phenomenon, comprising a heat-sensitive color developing layer formed on a substrate sheet and containing, in addition to a colorless dye precursor, color developing agent and binder, a heat-fusible sensitizing agent consisting essentially of at least one member selected from 1,4-bis(p-tolyloxy)benzene, 1,4-bis(3', 4'-dimethylphenyloxy)benzene and 1,4-bis(3',5'-dimethylphenyloxy)benzene, in an amount of 10% to 1,000% based on the weight of the color developing agent.