Abstract: Disclosed is a process for producing a pyrazole carboxylic acid derivative which is useful as a significant intermediate of an 11?HSD-1 inhibitor. A compound represented by the Formula (XI): is useful as a significant intermediate of an 11?HSD-1 inhibitor, wherein R1 and R2 are each independently hydrogen or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl and R4 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.

Abstract: The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect. A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein Rh and Rj are taken together to form a bond; Ra and Rb and/or Rd and Re are taken together to form oxo or the like; Rc is hydrogen, substituted or unsubstituted alkyl or the like; Rf is —(CR4aR4b)n—R2; R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like; R2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; —Rg is —X—R3; —X— is —O—, —S— or the like; R3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.

Abstract: An AI pipe (1) is formed with a first housing (11) and a second housing (21). The first housing (11) is made from a thin metal sheet and has a clamp portion (C1) that was left remaining. The second housing (21) is also made of a thin metal sheet and also has a clamp portion (C2) that was left remaining. When fitted together, the first housing (11) and the second housing (21) form a pipe portion (31). With this AI pipe (1), a through-hole (H) which is punched out by press working is formed in at least one of the clamping portion (C1) and the clamping portion (C2).

Abstract: There is provided a rolling bearing which comprises at least: an outer ring 10 and an inner ring 20 disposed rotatable relative to each other; and plurality of rolling elements 40 respectively interposed rollably between the outer and inner rings. The outer ring is fitted into a housing (not shown) and the inner ring is fitted with a shaft (not shown), whereby the rolling bearing supports rotation between the shaft and housing. Between the fitting surface (not shown) of the housing and the outer circumferential surface 13 of the outer ring and/or between the fitting surface of the shaft and the inner circumferential surface 23 of the inner ring, there is interposed an O-ring 30 made of an elastic member having a reduced friction coefficient between the fitting surface of the housing and the outer circumferential surface of the outer ring or between the fitting surface of the shaft and the inner circumferential surface of the inner ring.

Abstract: The present invention is directed to provide a novel preparation of anticancer-active tricyclic compounds via alkyne coupling reaction. The present invention provides a process for preparing a compound of formula (Ia) or (Ib): wherein R1 is optionally substituted C1-6 alkyl, etc.; W is O, S or NR2; R2 is hydrogen atom, etc., which comprises Step (a) in which a compound of formula (II): wherein R1 is the same as defined above, and a compound of formula (III) or (IV): wherein R2 is the same as defined above; R3 is hydrogen atom, etc.; X is halogen atom, etc., are reacted in the presence of a base, a copper catalyst and a palladium catalyst in an aprotic polar solvent.

Abstract: An oil pan (20) includes: a pair of oil pan rail portions (21a, 21b), which are spaced apart from each other under an engine body (10a), and are fastened to the engine body (10a); a pair of side wall portions (22a, 22b), facing each other, which are formed integrally with the oil pan rail portions (21a, 21b); and a cylindrical portion (23), which surrounds a driving axle (19L, 19R) passed through the oil pan (20), and is integrally joined with the pair of side wall portions (22a, 22b) near the pair of oil pan rail portions (21a, 21b). At least one axial end (23a, 23b) of the cylindrical portion (23), an upper half portion (23c) of the cylindrical portion (23) positioned over the driving axle (19L, 19R) is thickened upward up to the level near the upper surface of the oil pan rail portion (21a, 21b).

Abstract: One of the problems to be resolved by the present invention is to stably and sustainably produce active ingredients contained in Bignoniaceous plants of which a mass production is difficult in a conventional manner. The present invention relates to a method for efficiently preparing an anticancer active ingredient NQ801 by a cell cultivation of Bignoniaceous plants under specific culture conditions. An ingredient-production system in the present invention has an anticancer activity.

Abstract: There is provided a rolling bearing which comprises at least: an outer ring 10 and an inner ring 20 disposed rotatable relative to each other; and plurality of rolling elements 40 respectively interposed rollably between the outer and inner rings. The outer ring is fitted into a housing (not shown) and the inner ring is fitted with a shaft (not shown), whereby the rolling bearing supports rotation between the shaft and housing. Between the fitting surface (not shown) of the housing and the outer circumferential surface 13 of the outer ring and/or between the fitting surface of the shaft and the inner circumferential surface 23 of the inner ring, there is interposed an O-ring 30 made of an elastic member having a reduced friction coefficient between the fitting surface of the housing and the outer circumferential surface of the outer ring or between the fitting surface of the shaft and the inner circumferential surface of the inner ring.

Abstract: An oil pan (20) includes: a pair of oil pan rail portions (21a, 21b), which are spaced apart from each other under an engine body (10a), and are fastened to the engine body (10a); a pair of side wall portions (22a, 22b), facing each other, which are formed integrally with the oil pan rail portions (21a, 21b); and a cylindrical portion (23), which surrounds a driving axle (19L, 19R) passed through the oil pan (20), and is integrally joined with the pair of side wall portions (22a, 22b) near the pair of oil pan rail portions (21a, 21b). At least one axial end (23a, 23b) of the cylindrical portion (23), an upper half portion (23c) of the cylindrical portion (23) positioned over the driving axle (19L, 19R) is thickened upward up to the level near the upper surface of the oil pan rail portion (21a, 21b).

Abstract: An object of the present invention is to provide a method for efficiently preparing (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]-furan-4,9-dione useful as a medicine at a low cost and in large amounts. According to the present invention, the desired (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione can be prepared with high efficiency at a low cost and in large amounts by asymmetrically reducing 2-acetyl-5-hydroxynaphtho[2,3-b]furan-4,9-dione in the presence of an asymmetric ruthenium complex and a hydrogen donor.

Abstract: An AI pipe (1) is formed with a first housing (11) and a second housing (21). The first housing (11) is made from a thin metal sheet and has a clamp portion (C1) that was left remaining. The second housing (21) is also made of a thin metal sheet and also has a clamp portion (C2) that was left remaining. When fitted together, the first housing (11) and the second housing (21) form a pipe portion (31). With this AI pipe (1), a through-hole (H) which is punched out by press working is formed in at least one of the clamping portion (C1) and the clamping portion (C2).

Abstract: An object of the present invention is to provide a method for efficiently preparing (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]-furan-4,9-dione useful as a medicine at a low cost and in large amounts. According to the present invention, the desired (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione can be prepared with high efficiency at a low cost and in large amounts by asymmetrically reducing 2-acetyl-5-hydroxynaphtho[2,3-b]furan-4,9-dione in the presence of an asymmetric ruthenium complex and a hydrogen donor.

Abstract: A magnetic head slider, for sliding on a magnetic disk, which has a leading edge, a trailing edge, an air bearing surface having a front step bearing of submicron depth made from the leading edge, and a rail surface made from the front step bearing. A negative pressure recess which is deeper than the front step bearing, is formed as a recess from the rail surf ace, and a side step bearing with a depth identical to that of the front step bearing is made from the rail surface. Side padB are provided which each have a width W and length L, wherein W is greater than L.

Abstract: A magnetic head slider for sliding on the magnetic disk, which comprises: a leading edge; a trailing edge, wherein the air bearing surface has a front step bearing with submicron depth of the air bearing surface was made from said leading edge in the continuity, a rail surface made from this front step bearing in the continuity, a negative pressure recess which is more profound than said front step bearing made in the continuity from this rail surface and a side step bearing with the depth identical with said front step bearing made in the continuity from the rail surface, whereby the ratio of depth R of said recess and depth ?s of said front step bearing is R/?s ?5.

Abstract: A magnetic head slider, for sliding on a magnetic disk, which comprises a leading edge, a trailing edge, an air bearing surface having a front step bearing of submicron depth made from the leading edge, and a rail surface made from the front step bearing. A negative pressure recess, which is more profound than the front step bearing, is made from the rail surface, and a side step bearing with a depth identical to that of the front step bearing is made from the rail surface, wherein the ratio of depth R of the recess and depth ?s of the front step bearing is R/?s?5.

Abstract: A magnetic disk drive includes a magnetic head slider, a magnetic head slider support mechanism for supporting the magnetic head slider and moving it to a predetermined position, and a load/unload mechanism for detaching the magnetic head slider from the surface of a magnetic disk or moving it thereto. When the magnetic head slider is detached from the magnetic disk surface for unloading, the magnetic head slider support mechanism is restrained against displacement in at least one direction perpendicular to the magnetic disk surface by a restraining part which is provided at a position, on other than the load/unload mechanism, between the magnetic head slider and a pivot of the magnetic head slider support mechanism.

Abstract: A magnetic head slider for sliding on the magnetic disk, which comprises:

Abstract: A magnetic head slider for sliding on a magnetic disk includes a leading edge, a trailing edge, an air bearing surface having a front step bearing of submicron depth made from the leading edge, and a rail surface made from the front step bearing. A negative pressure recess which is more profound than the front step bearing is made from the rail surface, and a side step bearing having a depth identical with the front step bearing is made from the rail surface. The ratio of the depth R of the recess to the depth &dgr;S of the front step bearing is R/&dgr;s>5.

Abstract: A magnetic head slider for sliding on the magnetic disk, which comprises: a leading edge; a trailing edge, wherein the air bearing surface has a front step bearing with submicron depth of the air bearing surface was made from said leading edge in the continuity, a rail surface made from this front step bearing in the continuity, a negative pressure recess which is more profound than said front step bearing made in the continuity from this rail surface and a side step bearing with the depth identical with said front step bearing made in the continuity from the rail surface, whereby the ratio of depth R of said recess and depth &dgr; s of said front step bearing is R/&dgr;s>5.

Abstract: In a magnetic disk drive which comprises a magnetic head slider, a magnetic head slider support mechanism for supporting the magnetic head slider and moving it to a predetermined position, and a load/unload mechanism for detaching the magnetic head slider from the surface of a magnetic disk or moving it thereto, when the magnetic head slider is detached from the magnetic disk surface for unloading, the magnetic head slider support mechanism is restrained against displacement in at least one direction perpendicular to the magnetic disk surface by a restraining part which is provided at a position, on other than the load/unload mechanism, between the magnetic head slider and a pivot of the magnetic head slider support mechanism. Thus, it is possible to enhance impact resistance of the magnetic disk drive during non-ration.