Publication number: 20220268790
Abstract: An evaluating method includes an evaluating step of evaluating a pharmacological action of an immune checkpoint inhibitor in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hAnthA, hIAA, hKyn, hTrp, IAA, ILA, Kyn, KynA, NFKyn, NP, PA, QA, Serot, and XA in blood of the subject to be evaluated, or (ii) a value of a formula calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value.
Type:
Application
Filed:
April 27, 2022
Publication date:
August 25, 2022
Applicant:
AJINOMOTO CO., INC.
Inventors:
Sachise KARAKAWA, Tomoyuki TAGAMI, Rumi NISHIMOTO, Shinya KIKUCHI, Akira IMAIZUMI, Koichi AZUMA, Tomoaki HOSHINO, Takaaki TOKITO, Hidenobu ISHII, Norikazu MATSUO
Publication number: 20210172958
Abstract: An evaluating method includes an evaluating step of evaluating a state of ketosis in postpartum dairy cows for a dairy cow using at least one value of concentration values of Ala, Arg, Asn, Asp, BCAA, Cit, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, 3MeHis, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, and Val and concentration values of ALB, ALT, AST, BHBA, BUN, Ca, gGTP, Glc, NEFA, T-Bil, TCHO, TG, and TP in blood of the dairy cow before parturition.
Type:
Application
Filed:
February 18, 2021
Publication date:
June 10, 2021
Applicant:
AJINOMOTO CO., INC.
Inventors:
Takashi MIKAMI, Akira IMAIZUMI, Takayuki TANAKA, Yuki MIYAZAWA, Mina NAKAMURA, Kazuki NAKAGAWA, Takeshi FUJIEDA
Patent number: 10962547
Abstract: An evaluating method includes an evaluating step of evaluating a state of ketosis in postpartum dairy cows for a dairy cow using at least one value of concentration values of Ala, Arg, Asn, Asp, BCAA, Cit, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, 3MeHis, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, and Val and concentration values of ALB, ALT, AST, BHBA, BUN, Ca, gGTP, Glc, NEFA, T-Bil, TCHO, TG, and TP in blood of the dairy cow before parturition.
Type:
Grant
Filed:
December 26, 2018
Date of Patent:
March 30, 2021
Assignee:
Ajinomoto Co., Inc.
Inventors:
Takashi Mikami, Akira Imaizumi, Takayuki Tanaka, Yuki Miyazawa, Mina Nakamura, Kazuki Nakagawa, Takeshi Fujieda
Publication number: 20190227071
Abstract: An evaluating method includes an evaluating step of evaluating a state of pancreatic cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of N-Me-bABA, bABA, GABA, N6-Acetyl-L-Lys, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, Homoarginine, Hypotaurine, Kinurenine, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.
Type:
Application
Filed:
April 2, 2019
Publication date:
July 25, 2019
Applicant:
AJINOMOTO CO., INC.
Inventors:
Hidehiro NAKAMURA, Natsumi NISHIKATA, Akira IMAIZUMI, Kazutaka SHIMBO, Naoko ARASHIDA, Rumi NISHIMOTO
Publication number: 20190228844
Abstract: An evaluating method includes an evaluating step of evaluating a state of colorectal cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of bABA, N-Me-bABA, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, GABA, Homoarginine, Hypotaurine, Kinurenine, N6-Acetyl-L-Lys, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, SDMA, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.
Type:
Application
Filed:
April 2, 2019
Publication date:
July 25, 2019
Applicant:
AJINOMOTO CO., INC.
Inventors:
Hidehiro NAKAMURA, Natsumi NISHIKATA, Akira IMAIZUMI, Kazutaka SHIMBO, Naoko ARASHIDA, Rumi NISHIMOTO
Publication number: 20190204332
Abstract: An evaluating method includes an evaluating step of evaluating a state of ketosis in postpartum dairy cows for a dairy cow using at least one value of concentration values of Ala, Arg, Asn, Asp, BCAA, Cit, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, 3MeHis, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, and Val and concentration values of ALB, ALT, AST, BHBA, BUN, Ca, gGTP, Glc, NEFA, T?Bil, TCHO, TG, and TP in blood of the dairy cow before parturition.
Type:
Application
Filed:
December 26, 2018
Publication date:
July 4, 2019
Applicant:
AJINOMOTO CO., INC.
Inventors:
Takashi MIKAMI, Akira IMAIZUMI, Takayuki TANAKA, Yuki MIYAZAWA, Mina NAKAMURA, Kazuki NAKAGAWA, Takeshi FUJIEDA