Abstract: A stippling tool comprising includes a cylindrical main body defining an ink containing chamber therein, a slender ink transfer member having a proximal end portion to which ink in the ink containing chamber is supplied, and a distal end portion extending to an opening of the main body, in which ink is transferred from the proximal end portion to the distal end portion, and a porous elastic stippling member provided on the distal end portion of the ink transfer member, through which the ink permeates. The stippling member having a stippling distal end surface outwardly projecting in a curved shape, and the distal end surface being elastically deformed by a stroke pressure.

Abstract: In a heavy duty pneumatic tire comprising a tread, the tread is made of a rubber composition comprising 20-67 parts by weight of carbon black and 3-20 parts by weight of silica based on 100 parts by weight of diene based rubber, wherein the carbon black has a ratio of a dibutyl phthalate (DBP) absorption to a 24M4 DBP absorption (DBP absorption/24M4 DBP absorption) of not less than 1.20 and a ratio of the DBP absorption to a nitrogen adsorption specific area (N2SA) of not less than 0.8.

Abstract: A magnetic disk device, which is provided with a magnetic head slider mounted with a magnetic head and a magnetic disk, and of which the magnetic head slider has the possibility of contacting the magnetic disk at the vicinity of the magnetic head,

Abstract: The present invention is to provide a polyamide laminated film comprising a resin layer A and a resin layer B formed on at least one surface of the resin layer A, the resin layer A being composed mainly of a m-xylylene group-containing polyamide polymer (a-1) which is one prepared from monomer components containing a xylylenediamine compound as a main diamine component and an &agr;,&ohgr;-aliphatic dicarboxylic acid having from 6 to 12 carbon atoms as a main dicarboxylic acid component, the xylylenediamine compound being m-xylylenediamine alone or a mixture of m-xylylenediamine and p-xylylenediamine, and the resin layer B being mainly composed of a mixed polymer (b-3) which is a mixture of from 99 to 80% by weight of an aliphatic polyamide (b-1) and from 1 to 20% by weight of an elastomer (b-2). The laminated film is good in a gas barrier property and also in a flexural fatigue resistance and a transparency.

Abstract: A lead material for an electronic part having no adverse effect on the environment, having excellent solderability, desirable welding strength during welding and a low degree of nonuniform thickness of the plated layer during reflow processing. The lead material has a first plated layer and a second plated layer, both of which do not contain Pb, laminated on the surface of a conductive substrate in such order. The melting point of the second plated layer is lower than that of the first plated layer. The first and second plated layers are made of a Sn substance and a Sn alloy, respectively or vice versa.

Abstract: A low-bed type seismic isolator for a display case, which includes: at least two lines of arcuate X-rails (3) fixed to a lower plate (1) on a foundation and having lower central portions and higher end portions; at least two lines of arcuate Y-rails (4) fixed to a lower surface of an upper plate (2) above the X-rails (3) and having higher central portions and lower end portions in a direction perpendicularly to the X-rails; connection blocks (5) having lower portions clamping the X-rails, upper portions clamping the Y-rails, and a disk spring provided at the central portions thereof; absorbers (8) disposed on the ends of the X-rails and Y-rails and recesses which fixedly accommodates support legs (7) fixed to the lower surface of the upper plate and protruded downwardly from a seismic isolation object.

Abstract: The present invention relates to D-pentofuranose derivatives represented by the following formulas (1) through (4): ##STR1## (wherein A represents a chlorobenzoyl group; R.sup.1 represents a hydrogen atom, an aliphatic lower acyl group, a substituted or unsubstituted benzoyl group; each of X and Y represents a lower alkyl group; Z represents an ethynyl group or tri-lower alkyl silylethynyl group; the sugar moiety in formula (1) represents xylose; and the sugar moiety of each of formulas (3) and (4) represents ribose). The present invention also relates to a process for preparing the compound (2) characterized by oxidizing the compound of formula (1) with a hypochlorite in the presence of a catalytic amount of 2,2,6,6-tetramethylpiperidinoxy compound, and these compounds are useful as intermediates in the synthesis of 3'-C-substituted ribonucleoside derivatives having excellent antitumor activities.

Abstract: A seismic isolation sliding bearing for a structure, is made up of a dish 1 having a conical concave surface having a predetermined inclination or a spherical concave surface in its central portion, and a bearing element 2 in which the bearing element includes a base 3 whose portion for contact with the concave surface of the dish 1 is formed by a low-friction material, and a holder 6 which holds the base 3 so as to press it against the concave surface of the dish 1. The seismic isolation sliding bearing of the present invention neither resonates to the vibration period of any earthquake nor causes a large oscillation during a normal small vibration, but has a restoring force because of its structure which enables the bearing element to readily return to its original position after an earthquake ceases.

Abstract: The present invention relates to 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides having excellent antitumor activity, represented by formula ?I!: ##STR1## wherein B represents a pyrimidine or purine base, R.sub.1 and R.sub.2, which may be the same or different, represent hydrogen, a cyano group or alkyl group, and R.sub.3 represents hydrogen or a phosphoric acid residue, and a method for producing the same, and a use of the same.

Abstract: The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): ##STR1## wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may be substituted by a group represented by the formula: ##STR2## in which R.sup.a, R.sup.b and R.sup.c are individually a lower alkyl group or a phenyl group, or an oxiranyl group which may have at least one lower alkyl group, R.sup.1 and R.sup.2 individually represent H or an ester-forming residue capable of easily leaving in a living body, and R.sup.3 is H, a mono- or polyphosphoric acid residue, or an ester-forming residue capable of easily leaving in a living body, with the proviso that the sugar moiety is ribose, or a pharmaceutically acceptable salt thereof. The 3'-substituted nucleoside derivative according to the invention has an excellent antitumor activity and is hence useful for treatment for and prevention of cancers.

Abstract: 2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, anticancer compositions containing one or more of these compounds and methods for production of these compounds.Said compounds and salts thereof exhibit noticeable antitumor activities and are useful as anticancer agents.

Abstract: The present invention is directed toward anionic polymerization employing lithio aldimines mixed with an organic alkali metal compound and optionally, a chelating reagent. The lithio aldimines have the general formula (A)Li, where A is derived from a substituted aldimine. The invention is also directed toward polymers and other products made using the initiator, and methods therefor. Further, the invention contemplates a polymer, a polymer composition and products therefrom, which include a functional group from the reaction product of a substituted aldimine and an organolithium compound. The resulting polymers may be modified with a terminating, coupling or linking agent, which may provide the polymer with a multifunctionality.

Abstract: Novel 2'-methylidenenucleotide compounds of the formula (I) ##STR1## wherein R is a hydrogen or a halogen, R.sup.1 and R.sup.2 are the same or different and each is a fatty acid residue or a hydrocarbon residue, and R.sup.3 and R.sup.4 are the same or different and each is a hydrogen, a halogen or an alkyl; salts thereof; methods for production thereof; and pharmaceutical use thereof. The compounds and salts thereof show an excellent antitumor effect in mammals. More specifically, they show a remarkable activity of inhibiting growth of mouse tumors, cultured human tumor cells, and human tumors transplanted to nude mice, and are useful for the treatment and prevention of recurrence of lung cancer, gastrointestinal cancer, breast cancer, cervical cancer, gynecological cancer, urinological cancer, leukemia, melanoma, lymphogenous metastatic tumor and the like in mammals. They are also useful as antitumor agents since they have an increased bioavailability and low toxicity.

Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.

Abstract: A process for preparing a compound of the formula: ##STR1## wherein R.sup.1 is a hydroxyl or an amino which may optionally be substituted; R.sup.2 is a hydrogen or a C.sub.1 -C.sub.4 alkyl; and R.sup.4a and R.sup.5a together represent a group of the formula: --R.sup.6 R.sup.7 Si--O--SiR.sup.6' R.sup.7', wherein R.sup.6, R.sup.7, R.sup.6' and R.sup.7' are the same or different and each is a C.sub.1 -C.sub.4 alkyl, which process comprises reacting a reducing agent and a cyanolating agent with a compound of the formula: ##STR2## wherein R.sup.9 is an alkoxythiocarbonyl having a C.sub.1 -C.sub.4 alkyl or an arylthiocarbonyl having a C.sub.6 -C.sub.10 aryl.

Abstract: The pyrimidine compounds of the present invention are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein, R.sup.1 represents a hydroxyl or an amino which may be substituted by an acyl group; R.sup.2 represents a hydrogen atom or an alkyl having 1 to 4 carbons; R.sup.3 represents a hydrogen or a hydroxyl; and R.sup.4 and R.sup.5 each represent a hydrogen or together form a group --R.sup.6 R.sup.7 Si--O--SiR.sup.6' R.sup.7' --, wherein R.sup.6, R.sup.7, R.sup.6' and R.sup.7' are the same or different from one another and each represent an alkyl having 1 to 4 carbons. The compounds of the present invention exhibit an excellent antitumor effect.

Abstract: A plating method for a nickel-titanium alloy member is provided which comprises the steps of: subjecting a nickel-titanium alloy member to an anodic electrolyzing treatment and a cathodic electrolyzing treatment in succession by using an electrolyte containing hydrochloric acid as an essential component thereof, in particular, an electrolyte having a chloride ion concentration of 0.1 mol/l or more and a pH value of 2 or less, or an electrolyte having a chloride ion concentration of 0.4 mol/l or more, or still preferably, an electrolyte having a chlorine ion concentration of 0.3 mol/l or more and a pH value of 2 or less; strike plating the treated nickel-titanium alloy member with a desired metal; and electroplating the struck nickel-titanium alloy member with a desired metal. The adhesion between the nickel-titanium alloy member and a plating layer is very good.

Abstract: The present invention relates to a novel compound represented by the following formula [I] which is useful as a synthetic intermediate of a 2-alkynyladenosine.The present invention also relates to a process for producing the compound and a process for producing a 2-alkynyladenosine [IV] by way of the compound.Further, the present invention relates to a 2-alkynyladenosine derivative represented by the following formula [V] having excellent storage stability and, to a method of storing the 2-alkynyladenosine in the form of that derivative. ##STR1## [I] A=a leaving group, [II] A=NH.sub.2,[V] A=NHR.sup.4,wherein R.sup.1 through R.sup.4 represent a hydrogen atom or a protective group, and n denotes an integer of 1 to 15, provided that R.sup.1 through R.sup.4 do not represent a hydrogen atom simultaneously.

Abstract: Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof. These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent. Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

Abstract: In a polypropylene resin/silicone rubber integrally molded article, a polypropylene resin having an aliphatic unsaturated bond is integrally joined to an addition type silicone rubber at high bond strength. It is prepared by injection molding a modified polypropylene resin into a preform, injection molding a silicone rubber composition over the preform, and curing the composition at a temperature below the softening point of the polypropylene resin. Stronger bond is established when the silicone rubber contains a tackifier in the form of a compound containing in a molecule at least one hydrogen atom directly attached to a silicon atom and an alkoxysilyl, glycidyl or acid anhydride group or a --(CH.sub.2).sub.n -- linkage.