Patents by Inventor Alain Claude
Alain Claude has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12380968Abstract: A method for executing multiple chemical programs in parallel in an array of chemical reactors using a single array of substance containers may be provided. The method includes receiving a plurality of chemical programs, building a plurality of records comprising each a chemical program. Thereby, each record includes a key and a data field, wherein the key is indicative of the reactants required for the respective chemical reaction, and wherein the data field includes the chemical program. The method further includes creating an ordered data structure of the data records based on the keys, selecting a next record from the ordered data structure, assigning the selected next record to selected ones of the array of chemical reactors, repeating the steps of selecting and assigning until, as a maximum, each chemical reactor has a defined record assigned to it, and executing the chemical programs according to their defined records in parallel.Type: GrantFiled: August 18, 2020Date of Patent: August 5, 2025Assignee: International Business Machines CorporationInventors: Leonidas Georgopoulos, Aleksandros Sobczyk, Alain Claude Vaucher, Philippe Schwaller, Joppe Geluykens, Teodoro Laino
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Patent number: 11854670Abstract: A method for executing multiple chemical experiments in parallel may be provided. The method comprises receiving a list of actions to be performed for synthesizing a chemical product. Thereby, the actions correspond to at least two chemical partial reactions and the list comprises a delimiter symbol separating two chemical partial reactions, determining identical chemical partial reactions, and building a reaction commonality tree (RCT) of the chemical reactions. Furthermore, the method comprises executing a plurality of the identical chemical partial reactions independent of a sequence of chemical partial reactions of the reaction commonality tree only once. Each of the identical chemical partial reactions is executed in a different chemical reactor and each resulting intermediate product has a quantity of the sum of the related identical chemical partial reactions.Type: GrantFiled: August 18, 2020Date of Patent: December 26, 2023Assignee: International Business Machines CorporationInventors: Leonidas Georgopoulos, Aleksandros Sobczyk, Alain Claude Vaucher, Philippe Schwaller, Vishnu Harikrishnan Nair, Joppe Geluykens, Teodoro Laino
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Publication number: 20220359045Abstract: Disclosed is a method for predicting at least one aspect of an enzymatically catalyzed chemical reaction. The method comprises providing a trained machine learning model, and inputting one or two input strings into the training model. Each input string is selected from a group of strings consisting of: a string representation of at least one educts of the chemical reaction, a string representation of at least one product of the chemical reaction, and/or a string representation of amino acids of an enzyme which is supposed to transform the educts into the products in the reaction. The trained machine learning model predicts at least the one or more strings which were not provided as input and the prediction is performed as a function of the one or two strings provided as input. The method outputting the prediction result for predicting or optimizing the chemical reaction.Type: ApplicationFiled: May 7, 2021Publication date: November 10, 2022Inventors: Matteo Manica, Teodoro Laino, Daniel Probst, Alain Claude Vaucher
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Patent number: 11485710Abstract: Disclosed are compounds having the formula: wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.Type: GrantFiled: January 22, 2021Date of Patent: November 1, 2022Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Niall Andrew Anderson, Deepak Bandyopadhyay, Alain Claude-Marie Daugan, Frederic G. Donche, Patrick M. Eidam, Nicolas Eric Faucher, Nicolas S. George, Philip Anthony Harris, Jae U. Jeong, Bryan W. King, Clark A. Sehon, Gemma Victoria White, David Duff Wisnoski
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Publication number: 20220257569Abstract: The present application pertains to methods of using indole-oxadiazole compounds of Formula I to modulate cannabinoid receptor activity: I In particular diseases, disorders or conditions that benefit from modulating cannabinoid receptor activity, such as non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), schizophrenia, bipolar disorder, psychosis, metabolic syndrome, type-2 diabetes, dyslipidaemia, obesity, eating disorders, cardiovascular diseases and disorders, and other conditions as described herein, may be treated. Also included in the present application are certain novel compounds of Formula Ia and pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: September 12, 2019Publication date: August 18, 2022Applicants: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEENInventors: Iain Robert GREIG, Ruth ROSS, Amy RAMSEY, Catherine MIELNIK, Laurent Alain Claude TREMBLEAU, Mostafa Hamed ABDELRAHMAN
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Publication number: 20220059193Abstract: A method for executing multiple chemical programs in parallel in an array of chemical reactors using a single array of substance containers may be provided. The method includes receiving a plurality of chemical programs, building a plurality of records comprising each a chemical program. Thereby, each record includes a key and a data field, wherein the key is indicative of the reactants required for the respective chemical reaction, and wherein the data field includes the chemical program. The method further includes creating an ordered data structure of the data records based on the keys, selecting a next record from the ordered data structure, assigning the selected next record to selected ones of the array of chemical reactors, repeating the steps of selecting and assigning until, as a maximum, each chemical reactor has a defined record assigned to it, and executing the chemical programs according to their defined records in parallel.Type: ApplicationFiled: August 18, 2020Publication date: February 24, 2022Inventors: Leonidas Georgopoulos, Aleksandros Sobczyk, Alain Claude Vaucher, Philippe Schwaller, Joppe Geluykens, Teodoro Laino
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Publication number: 20220059192Abstract: A method for executing multiple chemical experiments in parallel may be provided. The method comprises receiving a list of actions to be performed for synthesizing a chemical product. Thereby, the actions correspond to at least two chemical partial reactions and the list comprises a delimiter symbol separating two chemical partial reactions, determining identical chemical partial reactions, and building a reaction commonality tree (RCT) of the chemical reactions. Furthermore, the method comprises executing a plurality of the identical chemical partial reactions independent of a sequence of chemical partial reactions of the reaction commonality tree only once. Each of the identical chemical partial reactions is executed in a different chemical reactor and each resulting intermediate product has a quantity of the sum of the related identical chemical partial reactions.Type: ApplicationFiled: August 18, 2020Publication date: February 24, 2022Inventors: Leonidas Georgopoulos, Aleksandros Sobczyk, Alain Claude Vaucher, Philippe Schwaller, Vishnu Harikrishnan Nair, Joppe Geluykens, Teodoro Laino
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Publication number: 20220058337Abstract: A computer-implemented method for generating an organic synthesis procedure from a simplified molecular-input line-entry system (SMILES) string may be provided. The method includes receiving a plurality of SMILES strings describing a desired chemical product and required reactants, and predicting procedure steps for an organic synthesis procedure for producing the desired chemical product by a deep machine-learning model system trained with sets of SMILES strings describing respective desired chemical products, reactants and related procedure steps as training data. The sets can be extracted from a corpus of associated chemical documents, and the predicted procedure steps are human readable. The method includes further receiving a modification signal for a modification to the predicting procedure steps, storing the plurality of received SMILES strings, the predicted procedure steps and the modification of the predicting procedure steps.Type: ApplicationFiled: August 18, 2020Publication date: February 24, 2022Inventors: Leonidas Georgopoulos, Joppe Geluykens, Alain Claude Vaucher, Philippe Schwaller, Aleksandros Sobczyk, Vishnu Harikrishnan Nair, Teodoro Laino
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Publication number: 20210253532Abstract: Disclosed are compounds having the formula: wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.Type: ApplicationFiled: January 22, 2021Publication date: August 19, 2021Inventors: Niall Andrew Anderson, Deepak Bandyopadhyay, Alain Claude-Marie Daugan, Frederic G. Donche, Patrick M. Eidam, Nicolas Eric Faucher, Nicolas S. George, Philip Anthony Harris, Jae U. Jeong, Bryan W. King, Clark A. Sehon, Gemma Victoria White, David Duff Wisnoski
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Publication number: 20210117869Abstract: Method(s), apparatus and system(s) are provided for generating and using an ensemble model. The ensemble may be generated by training a plurality of models based on a plurality of datasets associated with compounds; calculating model performance statistics for each of the plurality of trained models; selecting and storing a set of optimal trained model(s) from the trained models based on the calculated model performance statistics; and forming one or more ensemble models, each ensemble model comprising multiple models from the set of optimal trained model(s). The ensemble model may be used by retrieving the ensemble model and inputting, to the ensemble model, data representative of one or more labelled dataset(s) used to generate and/or train the model(s) of the ensemble model; and receiving, from the ensemble model, output data associated with labels of the one or more labelled dataset(s).Type: ApplicationFiled: March 29, 2019Publication date: April 22, 2021Applicant: BENEVOLENTAI TECHNOLOGY LIMITEDInventors: Dean PLUMBLEY, Matthew SELLWOOD, Marco FISCATO, Alain Claude VAUCHER
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Patent number: 10899716Abstract: Disclosed are compounds having the formula: wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.Type: GrantFiled: January 31, 2020Date of Patent: January 26, 2021Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITEDInventors: Niall Andrew Anderson, Deepak Bandyopadhyay, Alain Claude-Marie Daugan, Frederic G. Donche, Patrick M. Eidam, Nicolas Eric Faucher, Nicolas S. George, Philip Anthony Harris, Jae U. Jeong, Bryan W. King, Clark A. Sehon, Gemma Victoria White, David Duff Wisnoski
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Publication number: 20200165205Abstract: Disclosed are compounds having the formula: wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.Type: ApplicationFiled: January 31, 2020Publication date: May 28, 2020Inventors: Niall Andrew ANDERSON, Deepak BANDYOPADHYAY, Alain Claude-Marie DAUGAN, Frederic G. DONCHE, Patrick M. EIDAM, Nicolas Eric FAUCHER, Nicolas S. GEORGE, Philip Anthony HARRIS, Jae U. JEONG, Bryan W. KING, Clark A. SEHON, Gemma Victoria WHITE, David Duff WISNOSKI
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Patent number: 10590085Abstract: Disclosed are compounds having the formula (I): wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.Type: GrantFiled: May 19, 2016Date of Patent: March 17, 2020Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITEDInventors: Niall Andrew Anderson, Deepak Bandyopadhyay, Alain Claude-Marie Daugan, Frederic G. Donche, Patrick M. Eidam, Nicolas Eric Faucher, Nicolas S. George, Philip Anthony Harris, Jae U. Jeong, Bryan W. King, Clark A. Sehon, Gemma Victoria White, David Duff Wisnoski
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Publication number: 20190345138Abstract: Disclosed are compounds having the formula: wherein R1 and R2 are as defined herein, and methods of making and using the same.Type: ApplicationFiled: November 17, 2017Publication date: November 14, 2019Inventors: Alain Claude-Marie DAUGAN, Frederic G. DONCHE, Nicolas Eric FAUCHER, Nicolas S. GEORGE
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Publication number: 20180237441Abstract: The invention is directed to substituted pyrrolidinone and imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined herein.Type: ApplicationFiled: September 15, 2016Publication date: August 23, 2018Inventors: Jeffrey Michael AXTEN, Alain Claude-Marie DAUGAN, Nicolas Eric FAUCHER, Raghava Reddy KETHIRI, Rajendra KRISTAM, Chandregowda VENKATESHAPPA
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Publication number: 20180134665Abstract: Disclosed are compounds having the formula (I): wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.Type: ApplicationFiled: May 19, 2016Publication date: May 17, 2018Inventors: Niall Andrew ANDERSON, Deepak BANDYOPADHYAY, Alain Claude-Marie DAUGAN, Frederic G. DONCHE, Patrick M. EIDAM, Nicolas Eric FAUCHER, Nicolas S. GEORGE, Philip Anthony HARRIS, Jae U. JEONG, Bryan W. KING, Clark A. SEHON, Gemma Victoria WHITE, David Duff WISNOSKI
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Patent number: 9855260Abstract: The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.Type: GrantFiled: May 11, 2015Date of Patent: January 2, 2018Assignee: GLAXOSMITHKLINE LLCInventors: Alain Claude-Marie Daugan, Yann Lamotte, Olivier Mirguet
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Publication number: 20150238480Abstract: The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.Type: ApplicationFiled: May 11, 2015Publication date: August 27, 2015Inventors: Alain Claude-Marie DAUGAN, Yann LAMOTTE, Olivier MIRGUET
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Patent number: 9061998Abstract: The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.Type: GrantFiled: March 5, 2012Date of Patent: June 23, 2015Assignee: GlaxoSmithKline LLCInventors: Alain Claude-Marie Daugan, Olivier Mirguet, Yann Lamotte
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Publication number: 20130345243Abstract: The present invention relates to pyrimidinedione compounds of formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds of formula (I) or salts thereof as activators of AMPK.Type: ApplicationFiled: March 5, 2012Publication date: December 26, 2013Applicant: GLAXOSMITHKLINE LLCInventors: Anne Marie Jeanne Bouillot, Alain Claude-Marie Daugan, Yann Lamotte, Olivier Mirguet