Patents by Inventor Alain Claude
Alain Claude has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030153575Abstract: Compounds of a general structural formula (I) and salts and solvates thereof, and use of the compounds as PDES inhibitor.Type: ApplicationFiled: November 22, 2002Publication date: August 14, 2003Inventors: Mark W. Orme, Alain Claude-Marie Daugan, Agnes Bombrun
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Patent number: 6576768Abstract: Preparation of alkylthio and/or arylthio-substituted diketo-diaryl-pyrrolopyrroles (DPPs) of the formula Ia and dithio-bridged bis-diketo-diaryl-pyrrolopyrroles (bis-DPPs) of the formula Ib in which in formula Ia G is phenyl substituted by at least one arylthio or alkylthio group, and G1 is G or a carbocyclic or heterocyclic radical, by reacting a haloaryl with a thiol or thiolate, and in formula Ib G5 is a phenylene, G6 is G1 but not G, and G7 is alkylene, cycloalkylene or phenylene, by reacting two haloaryls with a dithiol or dithiolate, which comprises reacting a thiol or thiolate with a halo-diketo-diaryl-pyrrolopyrrole (“halo-DPP”) of the formula IIa in which G2 is a halogenated phenyl group and G3 is G2 or G1, or reacting a dithiol or dithiolate with two halo-diketo-diaryl-pyrrolopyrroles (“halo-DPPs”) of the formula IIb in which Hal is halogen such as fluorine, chlorine, bromine or iodine, and G6 is G1, and also novel DPPs aType: GrantFiled: April 20, 1999Date of Patent: June 10, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Zhimin Hao, Alain Claude Rochat, Nancy Schlöder-Tebaldi
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Patent number: 6552022Abstract: The invention relates to therapeutic benzamide compounds of formula (I) wherein A, X, Z, R1, Y, R2, R3, are as defined herein, and physiologically acceptable salts, solvates or derivatives thereof. The present invention also provides pharmaceutical compositions, processes for the preparation of compounds of formula (I) and their use in the treatment of conditions mediated by ApoB-100 regulation.Type: GrantFiled: May 15, 2001Date of Patent: April 22, 2003Assignee: SmithKline Beecham CorporationInventor: Alain Claude-Marie Daugan
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Publication number: 20020119976Abstract: A compound of formula (I) 1Type: ApplicationFiled: February 5, 2002Publication date: August 29, 2002Applicant: ICOS CorporationInventor: Alain Claude-Marie Daugan
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Patent number: 6369059Abstract: A compound of formula (I) and salts and solvates thereof, in which: R0 represents hydrogen, halogen or C1-6 alkyl; R1 represents hydrogen, C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, haloC1-6alkyl, C3-8cycloalkyl, C3-8cycloalkylC1-3alkyl, arylC1-3alkyl or heteroarylC1-3alkyl; R2 represents an optionally substituted monocyclic aromatic ring selected from benzene, thiophene, furan and pyridine or an optionally substituted bicyclic ring attached to the rest of the molecule via one of the benzene ring carbon atoms and wherein the fused ring A is a 5- or 6-membered ring which may be saturated or partially or fully unsaturated and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulphur and nitrogen; and R3 represents hydrogen or C1-3 alkyl, or R1 and R3 together represent a 3- or 4-membered alkyl or alkenyl chain.Type: GrantFiled: August 7, 2000Date of Patent: April 9, 2002Assignee: ICOS CorporationInventor: Alain Claude-Marie Daugan
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Patent number: 6218400Abstract: A compound of formula and salts and solvates thereof, wherein R0, R1, and R2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor of cGMP-specific PDE and has utility in a variety of therapeutic areas where such inhibition is beneficial.Type: GrantFiled: August 24, 1999Date of Patent: April 17, 2001Assignee: ICOS CorporationInventors: Alain Claude-Marie Daugan, Richard Frederic LaBaudiniere
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Patent number: 6143757Abstract: Compounds of the general structural formula ##STR1## and use of the compounds and salts and solvates thereof, as therapeutic agents.Type: GrantFiled: September 16, 1998Date of Patent: November 7, 2000Assignee: ICOS CorporationInventors: Alain Claude-Marie Daugan, Richard Frederick LaBaudiniere
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Patent number: 6143746Abstract: A compound of formula (I) and salts and solvates thereof, in which: R.sup.0 represents hydrogen, halogen, or C.sub.1-6 alkyl; R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, haloC.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkylC.sub.1-3 alkyl, arylC.sub.1-3 alkyl, or heteroarylC.sub.1-3 alkyl; R.sup.2 represents an optionally substituted monocyclic aromatic ring selected from benzene, thiophene, furan, and pyridine, or an optionally substituted bicyclic ring (a) attached to the rest of the molecule via one of the benzene ring carbon atoms, and wherein the fused ring (A) is a 5- or 6-membered ring which may be saturated or partially or fully unsaturated, and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulphur, and nitrogen; and R.sup.3 represents hydrogen or C.sub.1-3 alkyl, or R.sup.1 and R.sup.3 together represent a 3- or 4-membered alkyl or alkenyl chain.Type: GrantFiled: September 16, 1998Date of Patent: November 7, 2000Assignee: ICOS CorporationInventors: Alain Claude-Marie Daugan, Francoise Gellibert
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Patent number: 6140329Abstract: The use of (6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-p yrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione, (3S 6R,12aR)-2,3,6,7,12,12a-hexahydro-2,3-dimethyl-6-(3,4-methylenedioxyhenyl) -pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione, and physiologically acceptable salts and solvates thereof, in methods and compositions for the treatment of impotence.Type: GrantFiled: March 10, 1998Date of Patent: October 31, 2000Assignee: ICOS CorporationInventor: Alain Claude-Marie Daugan
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Patent number: 6127542Abstract: A compound of formula (I) ##STR1## and salts and solvates thereof, in which: R.sup.0 represents hydrogen, halogen or C.sub.1-6 alkyl;R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, haloC.sub.1-6 alkyl, C.sub.3-8 cyloalkyl, C.sub.3-8 cycloalkylC.sub.1-3 alkyl, arylC.sub.1-3 alkyl or heteroarylC.sub.1-3 alkyl;R.sup.2 represents an optionally substituted monocyclic aromatic ring selected from benzene, thiophene, furan and pyridine or an optionally substituted bicyclic ring ##STR2## attached to the rest of the molecule via one of the benzene ring carbon atoms and wherein the fused ring A is a 5- or 6-membered ring which may be saturated or partially or fully unsaturated and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulphur and nitrogen; andR.sup.3 represents hydrogen or C.sub.1-3 alkyl, or R.sup.1 and R.sup.3 together represent a 3- or 4-membered alkyl or alkenyl chain.Type: GrantFiled: September 21, 1999Date of Patent: October 3, 2000Assignee: ICOS CorporationInventor: Alain Claude-Marie Daugan
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Patent number: 6025494Abstract: A compound of formula (I) ##STR1## and salts and solvates thereof, in which: R.sup.0 represents hydrogen, halogen or C.sub.1-6 alkyl;R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, haloC.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkylC.sub.1-3 alkyl, arylC.sub.1-3 alkyl or heteroarylC.sub.1-3 alkyl;R.sup.2 represents an optionally substituted monocyclic aromatic ring selected from benzene, thiophene, furan and pyridine or an optionally substituted bicyclic ring ##STR2## attached to the rest of the molecule via one of the benzene ring carbon atoms and wherein the fused ring A is a 5- or 6-membered ring which may be saturated or partially or fully unsaturated and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulphur and nitrogen; andR.sup.3 represents hydrogen or C.sub.1-3 alkyl, or R.sup.1 and R.sup.3 together represent a 3- or 4-membered alkyl or alkenyl chain.Type: GrantFiled: August 12, 1998Date of Patent: February 15, 2000Assignee: ICOS CorporationInventor: Alain Claude-Marie Daugan
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Patent number: 6001847Abstract: A compound of formula ##STR1## and salts and solvates thereof, wherein R.sup.0, R.sup.1, and R.sup.2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor of cGMP-specific PDE and has utility in a variety of therapeutic areas where such inhibition is beneficial.Type: GrantFiled: June 8, 1998Date of Patent: December 14, 1999Assignee: ICOS CorporationInventors: Alain Claude-Marie Daugan, Richard Frederic LaBaudiniere
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Patent number: 5981527Abstract: A compound having the formula (I) ##STR1## and solvates thereof, wherein: R.sup.0 represents hydrogen, halogen or C.sub.1-6 alkyl;R.sup.1 represents hydrogen or C.sub.1-6 alkyl;R.sup.2 represents the bicyclic ring ##STR2## which may be optionally substituted by one or more groups selected from halogen and C.sub.1-3 alkyl; andR.sup.3 represents hydrogen or C.sub.1-3 alkyl is disclosed.The compounds are potent and selective inhibitors of cGMP-specific PDE, and are useful in a variety of therapeutic areas where such inhibition is beneficial.Type: GrantFiled: May 15, 1998Date of Patent: November 9, 1999Assignee: ICOS CorporationInventors: Alain Claude-Marie Daugan, Francoise Gellibert
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Patent number: 5973146Abstract: A process for the preparation of compounds of formula I ##STR1## by reacting a pyrrolopyrrole of formula ##STR2## wherein X.sub.1 is a group selected from ##STR3## X.sub.2 is a group selected from ##STR4## or has the same meaning as X.sub.1, with a secondary amine of formula ##STR5## in the molar ratio 1:2, in the presence of an anhydrous dipolar aprotic solvent and of an amount 0.1 to 15 times in excess of stoichiometric proportion, based on the amine of formula III, of an anhydrous organic base, in the temperature range from 50.degree. to 230.degree. C. and under a pressure from 0 to 10 bar.The substituents R.sub.1 to R.sub.8, Y and Hal are as defined in claim 1.The compounds of formula I are especially suitable for use as photoconductive substances.Type: GrantFiled: September 29, 1993Date of Patent: October 26, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Alain Claude Rochat, Olof Wallquist, Abul Iqbal, Jin Mizuguchi
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Patent number: 5859006Abstract: A compound of formula (I) ##STR1## and salts and solvates thereof, in which: R.sup.0 represents hydrogen, halogen or C.sub.1-6 alkyl;R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, haloC.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkylC.sub.1-3 alkyl, arylC.sub.1-3 alkyl or heteroarylC.sub.1-3 alkyl; R.sup.2 represents an optionally substituted monocyclic aromatic ring selected from benzene, thiophene, furan and pyridine or an optionally substituted bicyclic ring ##STR2## attached to the rest of the molecule via one of the benzene ring carbon atoms and wherein the fused ring A is a 5- or 6-membered ring which may be saturated or partially or fully unsaturated and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulphur and nitrogen; andR.sup.3 represents hydrogen or C.sub.1-3 alkyl, or R.sup.1 and R.sup.3 together represent a 3- or 4-membered alkyl or alkenyl chain.Type: GrantFiled: July 16, 1996Date of Patent: January 12, 1999Assignee: ICOS CorporationInventor: Alain Claude-Marie Daugan
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Patent number: 5663179Abstract: Compounds are described of general formula (I) ##STR1## and salts and solvates thereof, including physiologically acceptable salts and solvates thereof, in which:Z represents either Het, ##STR2## Het represents an optionally substituted bicyclic or tricyclic ring selected from acricine isoquinolin-1-yl, isoquinolin-3-yl,The novel compounds of formula (I) can sensitize multi-drug resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an anti-tumour drug.Type: GrantFiled: December 29, 1994Date of Patent: September 2, 1997Assignee: Laboratoires Glaxo SAInventors: Bernard Andre Dumaitre, Nerina Dodic, Alain Claude-Marie Daugan, Pascal Maurice Charles Pianetti
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Patent number: 4001266Abstract: Process for the manufacture of 2-(2-hydroxyphenyl)benztriazoles of the formula I ##STR1## wherein R.sub.1 denotes hydrogen or halogen, R.sub.2 denotes hydrogen, alkyl, alkoxy, alkylsulphonyl, acylamino, --SO.sub.3 H, --COOH or halogen, R.sub.3 denotes hydrogen, alkyl, cycloalkyl, aralkyl, aryl or halogen, R.sub.4 denotes hydrogen, alkyl, alkoxy or --OH and R.sub.5 denotes hydrogen, alkyl, cycloalkyl, aralkyl, aryl, carboxyalkyl, alkoxy, acylamino or halogen, characterized in that a 2-(2-hydroxyphenyl)-benztriazole-1 oxide in the formula III ##STR2## is reacted with 0.5 to 0.6 mol equivalent of hydrazine hydrate at a temperature above 100.degree. C, in a high-boiling ether as the solvent and in the presence of a base.Type: GrantFiled: November 25, 1974Date of Patent: January 4, 1977Assignee: Ciba-Geigy CorporationInventors: Jean Rody, Alain Claude Rochat
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Patent number: 3998804Abstract: Substituted 2-nitro-2'-hydroxy-azobenzenes are manufactured by coupling a phenol dispersed with a dispersing agent in water with a solution, in an inorganic acid, of a diazotized o-nitroaniline at a pH value not exceeding 2.The azobenzenes obtained are intermediate products for benztriazoles.Type: GrantFiled: May 6, 1975Date of Patent: December 21, 1976Assignee: Ciba-Geigy CorporationInventors: Jean Rody, Alain Claude Rochat, Hans Jakob Peterli, Robert Albrecht
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Patent number: D297313Type: GrantFiled: August 7, 1985Date of Patent: August 23, 1988Assignee: NOW S.A.Inventor: Alain Claude