Abstract: Provided herein are antibodies that specifically bind human CD38, formulations and unit dosage forms comprising the antibodies, methods of preparing the antibodies and methods of using the antibodies.

Abstract: Provided herein are antibodies that specifically bind human CD38, formulations and unit dosage forms comprising the antibodies, methods of preparing the antibodies and methods of using the antibodies.

Abstract: Provided herein are antibodies that specifically bind human CD38, formulations and unit dosage forms comprising the antibodies, methods of preparing the antibodies and methods of using the antibodies.

Abstract: Novel urotensin II receptor (UT) agonists and antagonists are described herein. More specifically, novel derivatives of urotensin II-related peptide (URP) are described herein.

Abstract: The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.

Abstract: The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.

Abstract: Novel urotensin ll receptor (UT) agonists and antagonists are described herein. More specifically, novel derivatives of urotensin ll-related peptide (URP) are described herein.

Abstract: The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide chelated with at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such us for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic is pulmonary embolus.

Abstract: A batting tee with two spaced apart support arms extending upwardly from the base plate, two spaced apart retaining members extending between the support arms and connected thereto or to the base plate, and a pivot extending between the support arms at a location intermediate that of the two retaining members. The shaft's bottom end is received between the two support arms and between the two retaining members and is connected adjacent the bottom end to the two support arms by the pivot extending therethrough. The pivot defining a single pivot axis about which the shaft is pivotable relative to the base plate between a first position in contact with only one of the retaining members and a second position in contact with only the other of the retaining members, for impact energy absorption.

Abstract: The invention concerns a method for protecting the data of an application compiled in intermediate for execution executed on a digital apparatus equipped with a virtual machine managing the execution of the code via a execution stack defining at least one stack frame corresponding to a method called during the execution of the code. A secured execution mode of the code involves the determination of at least one global checksum associated with each stack frame and, each time that a datum of the code is manipulated, the calculation of a local checksum associated with that datum. The calculation is on one hand, on the global checksum associated with the stack frame corresponding to the manipulated datum and, on the other hand, on at least one part of the other data constituting the stack frame.

Abstract: The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.

Abstract: The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.

Abstract: The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.

Abstract: A batting tee with two spaced apart support arms extending upwardly from the base plate, two spaced apart retaining members extending between the support arms and connected thereto or to the base plate, and a pivot extending between the support arms at a location intermediate that of the two retaining members. The shaft's bottom end is received between the two support arms and between the two retaining members and is connected adjacent the bottom end to the two support arms by the pivot extending therethrough. The pivot defining a single pivot axis about which the shaft is pivotable relative to the base plate between a first position in contact with only one of the retaining members and a second position in contact with only the other of the retaining members, for impact energy absorption.

Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant of human serum albumin, methods for preparation, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing fusion polypeptides.

Abstract: A turboprop engine includes a power jet mounted coaxially to the engine axis (X-X?), and has a fan case and a gas ejecting system provided with two afterbody half-cowlings (10b) each of which is pivotable around an axis (A2) between open and closed positions, wherein the half-cowlings are connected to the downstream of the fan case through a ‘V-blade/V-groove’ system. In a first embodiment, the pivot axes (A2) make an angle ?>3° to the engine axis (X, X?) and a joint plane (Z2-Z2) between the afterbody half-cowlings and the downstream of the fan case makes to the plane (Y, Y?) perpendicular to the engine axis (X, X?) an angle ? in such a way that the difference between the angle ? and the angle ? is less than or equal to 3°. In the other embodiment, the axes are converged to each other in a downstream direction.

Abstract: The invention concerns a method for protecting the data of an application compiled in intermediate for execution executed on a digital apparatus equipped with a virtual machine managing the execution of the code via a execution stack defining at least one stack frame corresponding to a method called during the execution of the code. A secured execution mode of the code involves the determination of at least one global checksum associated with each stack frame and, each time that a datum of the code is manipulated, the calculation of a local checksum associated with that datum. The calculation is on one hand, on the global checksum associated with the stack frame corresponding to the manipulated datum and, on the other hand, on at least one part of the other data constituting the stack frame.

Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Abstract: The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.

Abstract: The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity. to expression vectors comprising these sequences and to their use for the production of proteins.