Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Abstract: The cascade-type thrust reverser comprises a cowling in which there is formed an opening which, when in a direct thrust mode, is closed by a sliding cowl and which, in a thrust-reversal mode, is uncovered by the translation of the said sliding cowl, a fan duct being defined between an interior skin and an exterior skin, said exterior skin having a radius Re in the plane transversal to the longitudinal axis of the reverser and passing through the upstream end of the sliding cowl in the direct thrust mode, and said interior skin having, downstream of this upstream plane, a maximum radius Ri in a plane parallel to the upstream plane, the upstream end of the said sliding cowl substantially blocking the fan duct upstream of the said downstream plane in a thrust-reversal mode, the said radius Re being less than the radius Ri.

Abstract: The present invention relates to novel compounds and their pharmaceutical or diagnostic use, or use as a pharmacological target. More particularly, the present invention describes the identification of partners of the FE65 protein and the use of these partners, or of any compound which is capable of modulating, at least partially, their interaction with FE65, for regulating the activity of FE65, and in particular the phenomenon of intracellular transport or of endocytosis of the APP.

Abstract: A device for protecting the connection of a tubular conduit to a main tube of a maple sap collecting system wherein sap collected from maple trees are directed under vacuum to a pumping station of a sap processing center. The device comprises a band having a first end adapted to be mounted to the main tube and an opposite end adapted to be mounted externally onto the tubular conduit at a given distance from the main tube. This distance is greater than the distance between the first and opposite ends of the band so that accidental impact on the tubular conduit resulting from falling objects and tension applied to the attachment of the conduit to the main tube are taken by the band to thereby protect the connection of the tubular conduit to the adapter.

Abstract: The cascade-type thrust reverser comprises a cowling in which there is formed an opening which, when in a direct thrust mode, is closed by a sliding cowl and which, in a thrust-reversal mode, is uncovered by the translation of the said sliding cowl, a fan duct being defined between an interior skin and an exterior skin, said exterior skin having a radius Re in the plane transversal to the longitudinal axis of the reverser and passing through the upstream end of the sliding cowl in the direct thrust mode, and said interior skin having, downstream of this upstream plane, a maximum radius Ri in a plane parallel to the upstream plane, the upstream end of the said sliding cowl substantially blocking the fan duct upstream of the said downstream plane in a thrust-reversal mode, the said radius Re being less than the radius Ri.

Abstract: The invention discloses an aeroengine nacelle afterbody of the type comprising a common nozzle for exhausting the mixed hot and cold gases originating respectively from the fan duct and from the aeroengine combustion chamber, the said nozzle having a longitudinal axis more or less coincident with the axis of the said engine. The common exhaust nozzle consists of two half-nozzles which are more or less symmetric with respect to a plane containing the said longitudinal axis, the said half-nozzles being, on the one hand, individually hinged via one of their longitudinal edges to a support structure hanging down from the wing structure or from the fuselage of the aircraft and, on the other hand, lockable together along their opposite longitudinal edges.

Abstract: A process for the production of a resin piece by molding, places a self-demolding silicone membrane in a mold, and adds a catalyst to the resin to reduce the polymerization time of the resin so that the resin will not corrode the membrane.

Abstract: The invention concerns a backblast gas structure for jet engine comprising a thrust reversal system with two downstream doors. The invention is characterized in that the two tilt-up doors articulated about axes (6, 7) are mounted on two side beams (2, 3) with free downstream edges (16, 17) comprising protuberances (18, 19). The door downstream edges (13, 14) having median zones (13b, 14b) forming an angle (A) with the lateral parts (13a, 14a), such that when the doors are in retracted position in direct jet, the beam (13b, 14b) edges (16, 17) of the doors are found in the same plane (P2), thereby constituting a gas exhaust outlet which is planar and substantially circular. The invention aims at improving the power package performance in direct jet.

Abstract: This invention pertains to polynucleotides comprising GAX domains involved in GAX biological activity. It may pertain, notably, to domains involved in the interaction of GAX with other molecules or domains that are responsible for biological activity. The invention also pertains to chimeric molecules comprising a GAX functional domain. It also pertains to the use of GAX to repress gene expression, as well as the use of compounds that inhibit GAX interaction with certain cellular partners to modulate GAX activity. It also pertains to a method for screening and/or identifying GAX cellular partners.

Abstract: The thrust reverser for a turbo-fan engine is comprised of: a plurality of oors located in openings radially spaced in a shroud enclosing the engine and canalizing the jet flow from the engine, the doors being adapted to be pivoted, within a fixed structure, from a stowed position, in which they do not interfere with the jet flow, to a deployed position in which they block the jet flow and deflect it through the openings; an actuator having a body attached to the fixed structure and a rod attached to the center of each pivoting door for moving the door from the stowed position to the deployed position, and vice versa; and sealing elements comprising a main seal provided on the fixed structure and a separate annular seal located around the actuator body, the sealing elements mating with each door, when in the stowed position, and with the fixed structure to prevent pressure leakage of the jet flow.

Abstract: A method for producing a sandwich-type panel with structural and acoustic properties and formed of a core with an open cellular structure. The method includes the steps of forming first and second skins by superimposing and hot-pressing at least two fabric plies of mineral or synthetic fibers impregnated with a thermoplastic resin, of forming in one of the skins perforations with a diameter of between about 0.5 and 1.5 mm, with a vacuum proportion of empty spaces on the surface of the skin of between about 10 and 25%, of after preparation of the skins applying on one face of the skins an epoxy adhesive coating, of forming a sandwich including the open cellular structure with the two skins on its opposing faces, and then of hot-pressing the sandwich at an appropriate temperature so as to polymerize the adhesive. During hot-pressing the pressure and duration are set so as to avoid any full or partial obstruction of the perforations of the perforated skin.

Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a natural variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Abstract: This invention relates to improved fungal cells and methods for producing recombinant products of improved quality and in high yields. More specifically, the present invention relates to fungal cells carrying specific modifications within their DNA sequences which cause them to exhibit at least a reduced capacity for O-glycosylating homologous and/or heterologous proteins, and the use of these cells as host cells to produce high yields of recombinant products.

Abstract: The present invention concerns yeasts of the genus Kluyveromyces having one or more genetic modifications of at least one gene coding for a protease, said gene reducing or modifying the proteolytic actively of said yeasts, as well as their use as a cellular host for the secretion of recombinant proteins.

Abstract: The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity, to expression vectors comprising these sequences and to their use for the production of proteins.

Abstract: Novel genetically engineered yeast strains of genus Kluyveromyces lactis, their preparation, and the use thereof for producing recombinant proteins, are described.

Abstract: Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is non-functional, containing a vector bearing a functional copy of said gene.

Abstract: A method for the solid phase synthesis of multi-sulfated peptides comprising coupling side-chain unprotected hydroxyamino acids to the peptide chain utilizing benzotriazol-1-yl-oxy-tris (dimethyl)-phosphonium hexafluorophosphate (BOP) as a coupling reagent.

Abstract: The present invention concerns yeasts of the genus Kluyveromyces having one or more genetic modifications of at least one gene coding for a protease, said gene reducing or modifying the proteolytic actively of said yeasts, as well as their use as a cellular host for the secretion of recombinant proteins.

Abstract: Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector bearing a functional copy of said gene.