Abstract: A heat exchanger is described which conforms to external surface contours of an aircraft, such as an airplane or a helicopter, having a turbo-prop assembly. The heat exchanger is provided to cool engine fluids, which rise in temperature during engine operation.

Abstract: A cart comprising a platform configured to support something being transported. The cart has primary wheels including two or more rows of three or more non-swivelable wheels wherein the lower-most points of the wheels in a row form an arc. The wheels longitudinally span at least a portion of the platform.

Abstract: Methods and apparatus are presented for obtaining clock data from Manchester coded serial data streams, in which received data is sampled at a sample rate higher than the serial data baud rate, multi-bit groups of transition bits are generated which individually indicate data transition locations in a corresponding multi-bit sampled data bit group, and clock data is derived using the multi-bit groups of transition bits without requiring receipt of synchronization data or receipt of a separate clock.

Abstract: A flow heater is provided including a heating element, a channel heated by said heating element for heating liquid flowing therethrough, and temperature sensing means in thermal communication with both the heating element and the channel so as to be sensitive to the temperature of the liquid in the channel and the temperature of the heating element.

Abstract: Methods and apparatus are presented for obtaining clock data from Manchester coded serial data streams, in which received data is sampled at a sample rate higher than the serial data baud rate, multi-bit groups of transition bits are generated which individually indicate data transition locations in a corresponding multi-bit sampled data bit group, and clock data is derived using the multi-bit groups of transition bits without requiring receipt of synchronization data or receipt of a separate clock.

Abstract: A method and apparatus sense the replacement of a used component with a new component within the apparatus using sensors within the apparatus. The method/apparatus can then automatically display a message on a graphic user interface of the apparatus in response to the sensing of the replacement. This message provides information for recycling the used component, and the message provides a shipping option for shipping the used component to an appropriate recycling location. If the shipping option is selected, the method/apparatus retrieves a shipping address from memory within the apparatus and prints a shipping label for shipping the used component to the recycling location using a printing engine operatively connected to the apparatus.

Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.

Abstract: This invention relates to DPP-IV inhibitory citrate or tartrate salts of pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that are physically and chemically stable, substantially non-deliquescent solids under ambient conditions.

Abstract: An image-capture device stabilizer comprising a plurality of frictionally engaged components. The components are, or are configurable into, parts such as an image-capture device platform, a gimbal apparatus, and one or more balancing arms. The image-capture device stabilizer is pre-balanced for a specific image-capture device, and can be constructed to be suitable with an image-capture device weighing less than 1 lb. The image-capture device stabilizer can be provided in a kit. The invention also includes a method of fabricating an image-capture device stabilizer.

Abstract: The present application relates to perfume systems and consumer products comprising new perfumes and/or such perfume systems, as well as processes for making and using such perfume systems and consumer products.

Abstract: The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods described herein use activity based probes (“ABPs”) that have an affinity moiety for directing the binding of the ABP to one or more catalytically active target enzymes, a reactive group for forming a covalent bond at an active site of the target enzyme(s), and a TAG (e.g., a detectable label, preferably a fluorophore). One or more ABPs may be combined with a protein-containing sample under conditions for binding and reaction of the ABP(s) with target enzyme(s) that are present in the sample. The resulting products may then be used to assess the active enzyme profile of the sample, and can be correlated to the presence, amount, or activity of one or more target enzyme(s) present in the original complex protein mixture.

Abstract: The present invention is directed to a method of treatment of a malcondition that can be regulated or normalized via inhibition of DPP-IV. The method involves administration of an effective amount of a pyrrolidine compound of the invention, such as would be present in a pharmaceutical composition of the invention, to mammals, especially humans, to affect a malcondition that can be regulated or normalized via inhibition of DPP-IV.

Abstract: A cart comprising a platform configured to support something being transported. The cart has primary wheels including two or more rows of three or more non-swivelable wheels wherein the lower-most points of the wheels in a row form an arc. The wheels longitudinally span at least a portion of the platform.

Abstract: The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.

Abstract: The present invention provides novel macrocyclic compounds that mimic peptide substrates of the hepatitis C viral protease and inhibit the viral protease, more particularly as inhibitors of the NS3 serine protease from hepatitis C virus. Methods for synthesis of the compounds are also provided. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment.

Abstract: A wheel mechanism having two or more rows of three or more wheels wherein the lower-most points of the wheels in a row an arc. The wheels may be disposed on runners affixed to a cart or be attached directly to a frame or floor component of the cart. An arced shape can be implemented by varying the diameter of the wheels or the attachment components. The wheel mechanism can be incorporated into various types of carts.

Abstract: Compounds that selectively inhibit dipeptidyl peptidase-IV over closely related dipeptidyl peptidases are those of Formula (I): as well as pharmaceutically acceptable salts thereof, cyclic isomers thereof, prodrugs thereof, and solvates thereof, where all the variables are defined herein. These compounds can be used, alone or in combination with other drugs, for the treatment of diabetes and related diseases.

Abstract: In the context of synthesizing heterocyclic boronic acid compounds, a convergent synthetic methodology is particularly efficient for preparing boropyrrolidines and derivatives of boropyrrolidines.

Abstract: Certain constrained cyano compounds are useful as inhibitors of post-proline/alanine cleaving amino-dipeptidases. Accordingly, these compounds can be employed, alone or with another therapeutic agent, to treat diabetes (especially, Type II diabetes), hyperglycemia, Syndrome X, diabetic complications, hyperinsulinemia, obesity, atherosclerosis and related diseases, as well as various immunomodulatory diseases and chronic inflammatory bowel disease.

Abstract: The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.