Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

Abstract: Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.

Abstract: A photosensitive transistor or voltage-mode device which comprises a gate electrode, a layer of ambipolar two-dimensional material such as graphene and a layer of photoactive semiconducting material forms a junction with the ambipolar two-dimensional material. The photoactive semiconducting material and the ambipolar two-dimensional material are configured so that there is a non-screening gate voltage interval where an interface voltage at the junction between the photoactive semiconducting layer and the ambipolar two-dimensional material can be changed by applying to the gate electrode a gate voltage which falls within the non-screening gate voltage interval. The non-screening gate voltage interval comprises a flat-band gate voltage at which the interface voltage is zero. An electrical shutter can be operated at this gate voltage.

Abstract: An apparatus and method, the apparatus including a sensor array including a plurality of first sensors configured to detect a first attribute; at least one second sensor configured to detect a second attribute; wherein the at least one second sensor is configured such that, in response to detecting a trigger input including the second attribute the second sensor enables a first portion of the sensor array to be powered on while a second portion of the sensor array remains powered off.

Abstract: An apparatus and method, the apparatus comprising: at least one charged substrate (3); a channel of two dimensional material (5); and at least one floating electrode (7A-C) wherein the floating electrode comprises a first area (10A-C) adjacent the at least one charged substrate, a second area (11A-C) adjacent the channel of two dimensional material and a conductive interconnection (9A-C) between the first area and the second area wherein the first area is larger than the second area and wherein the at least one floating electrode is arranged to control the level of doping within the channel of two dimensional material.

Abstract: An apparatus comprising: pyroelectric material; an electric field sensor; a first conductive electrode comprising a first area adjacent the pyroelectric material; a second conductive electrode comprising a second area adjacent the electric field sensor; and a conductive interconnection between the first conductive electrode and the second conductive electrode, wherein the first area of the first conductive electrode is larger than the second area of the second conductive electrode.

Abstract: An apparatus configured to alternate the application of first and second gate voltages to a gate electrode of a photodetector. A first change in electrical current is relative to a predetermined measurement of electrical current taken at the first gate voltage in the absence of incident electromagnetic radiation, and a second change in electrical current is relative to a predetermined measurement of electrical current taken at the second gate voltage in the absence of the incident electromagnetic radiation. The photodetector comprises a channel, and source and drain electrodes configured to enable flow of electrical current through the channel. Quantum dots are configured to generate charge carriers on exposure to the incident electromagnetic radiation. The gate electrode is configured to generate an electric field upon the application of a gate voltage thereto, and process the signal to at least partially remove any changes in electrical current which are attributed to noise.

Abstract: An apparatus comprising: pyroelectric material; an electric field sensor; a first conductive electrode comprising a first area adjacent the pyroelectric material; a second conductive electrode comprising a second area adjacent the electric field sensor; and a conductive interconnection between the first conductive electrode and the second conductive electrode, wherein the first area of the first conductive electrode is larger than the second area of the second conductive electrode.

Abstract: In accordance with an example embodiment of the present invention, a device comprising one or more porous graphene layers, the or each graphene porous layer comprising a multiplicity of pores. The device may form at least part of a flexible and/or stretchable, and or transparent electronic device.

Abstract: An apparatus and method wherein the apparatus comprises: a sensing material configured to produce a non-random distribution of free charges in response to a parameter; an electric field sensor; a first conductive electrode comprising a first area overlapping the sensing material; an insulator provided between the first conductive electrode and the sensing material; a second electrode comprising a second area adjacent the electric field sensor; and a conductive interconnection between the first conductive electrode and the second conductive electrode.

Abstract: An apparatus and method, the apparatus including a sensor array including a plurality of first sensors configured to detect a first attribute; at least one second sensor configured to detect a second attribute; wherein the at least one second sensor is configured such that, in response to detecting a trigger input including the second attribute the second sensor enables a first portion of the sensor array to be powered on while a second portion of the sensor array remains powered off.

Abstract: An apparatus comprising: —a piezoelectric convertor layer; and —a proximal first piezoresistive layer being in electrical communication with, a first face of the piezoelectric convertor layer, the apparatus being configured such that when the piezoelectric convertor layer is deformed to generate charge, the proximal piezoresistive layer is configured to control the flow of charge from the piezoelectric convertor layer.

Abstract: A multilayer graphene composite comprising a plurality of stacked graphene layers separated from one another by an ion gel, wherein the ion gel is intercalated between adjacent graphene layers such that ions within the ion gel are able to arrange themselves at the surfaces of the graphene layers to cause a detectable change in one or more of an electrical and optical property of the graphene layers when a gate voltage is applied to a gate electrode in proximity to the ion gel.

Abstract: An apparatus and method, the apparatus comprising: at least one charged substrate (3); a channel of two dimensional material (5); and at least one floating electrode (7A-C) wherein the floating electrode comprises a first area (10A-C) adjacent the at least one charged substrate, a second area (11A-C) adjacent the channel of two dimensional material and a conductive interconnection (9A-C) between the first area and the second area wherein the first area is larger than the second area and wherein the at least one floating electrode is arranged to control the level of doping within the channel of two dimensional material.

Abstract: An apparatus and method wherein the apparatus comprises: a sensing material configured to produce a non-random distribution of free charges in response to a parameter; an electric field sensor; a first conductive electrode comprising a first area over-lapping the sensing material; an insulator provided between the first conductive electrode and the sensing material; a second electrode comprising a second area adjacent the electric field sensor; and a conductive interconnection between the first conductive electrode and the second conductive electrode.

Abstract: An apparatus comprising: a sensor (1) configured to sense electromagnetic radiation (15) wherein the sensor (1) comprises a sensing portion (3) comprising a pyroelectric material (4) configured to be responsive to incident electromagnetic radiation (15) and a transducing portion (7) configured to convert the response of the pyroelectric material (4) into an output signal; and at least one antenna (21) configured to direct the electromagnetic radiation (15) onto the sensor (1).

Abstract: An apparatus (100) comprising: semiconductor (2); and an asymmetric electrode arrangement (10) comprising a first electrode (11), a second electrode (12) separated from the first electrode across a portion of the semiconductor and at least one surface plasmon polariton generator (20) associated with at least the first electrode (11).

Abstract: An apparatus comprising: a sensor (1) configured to sense electromagnetic radiation (15) wherein the sensor (1) comprises a sensing portion (3) comprising a pyroelectric material (4) configured to be responsive to incident electromagnetic radiation (15) and a transducing portion (7) configured to convert the response of the pyroelectric material (4) into an output signal; and at least one antenna (21) configured to direct the electromagnetic radiation (15) onto the sensor (1).

Abstract: An apparatus including first and second layers of electrically conductive material separated by a layer of electrically insulating material, wherein one or both layers of electrically conductive material include graphene, and wherein the apparatus is configured such that electrons are able to tunnel from the first layer of electrically conductive material through the layer of electrically insulating material to the second layer of electrically conductive material.

Abstract: An apparatus including a piezoelectric convertor layer; at least one piezoresistive layer on the piezoelectric convertor layer; and electrical conductor outputs. The at least one piezoresistive layer includes a plurality of spaced apart piezoresistive electrodes. The apparatus is configured such that when the piezoelectric convertor layer is deformed to generate a charge, at least one of the piezoresistive electrodes is stressed, where the at least one piezoresistive layer is configured to control flow of charge from the piezoelectric convertor layer. The electrical conductor outputs are electrically connected to the piezoresistive electrodes. The outputs are configured to allow the charge from the piezoelectric convertor layer to flow out of the piezoresistive electrodes.