Patents by Inventor Alan D. Hirschman
Alan D. Hirschman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8382704Abstract: A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movemenType: GrantFiled: December 20, 2007Date of Patent: February 26, 2013Assignee: Medrad, Inc.Inventors: Arthur E. Uber, III, David M. Griffiths, David M. Reilly, Alan D. Hirschman, Kevin P. Cowan, Mark Trocki
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Patent number: 8192397Abstract: A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.Type: GrantFiled: June 21, 2006Date of Patent: June 5, 2012Assignee: Medrad, Inc.Inventors: David M. Griffiths, Rosemary Almon-Martin, Alan D. Hirschman, David M. Reilly, Frederick W. Trombley, III, Arthur E. Uber, III, William Jaecklein
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Patent number: 8182444Abstract: A system for delivering a fluid comprising cells to tissue of a patient includes a container holding an injection fluid and a powered drive. A sensor system provides a measurement indicative of at least shear forces on the cells to a control system. Based at least in part on this measurement, the control system is adapted to transmit a control signal to the powered drive for pressurizing the contents of the container to deposit cells within the tissue of a patient via a fluid path and a patient interface. As an example, the cells can be pregenitor or stem cells.Type: GrantFiled: November 6, 2006Date of Patent: May 22, 2012Assignee: Medrad, Inc.Inventors: Arthur E. Uber, III, Alan D. Hirschman, David M. Griffiths, David M. Reilly, Kevin P. Cowan, Barry L. Tucker, David Mishler
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Patent number: 8055328Abstract: An interface unit enables communication with an injector system that is used for pressurizing a fluid medium for injection into a patient during an injection procedure. The interface unit includes a processor and a storage unit. The processor controls operation of the interface unit and enables exchange of digital information between the interface unit and the injector system. The storage unit, under control of the processor, records the digital information gathered from the injector system during communication therewith. The digital information includes at least injection profile, history and dose data pertaining to the injection procedure. The processor enables at least the injection profile, history and dose data of the digital information recorded within the storage unit of the interface unit to be communicable to at least one of an imaging system linked thereto and an external device linked thereto.Type: GrantFiled: August 4, 2009Date of Patent: November 8, 2011Assignee: MEDRAD, Inc.Inventors: Arthur E. Uber, III, Edward J. Rhinehart, Rosemary Almon-Martin, David M. Griffiths, Alan D. Hirschman, Francis J. Sciulli, Walter Grumski, Vera Pagano, Karen Zelenski
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Publication number: 20110178359Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.Type: ApplicationFiled: December 28, 2007Publication date: July 21, 2011Inventors: Alan D. Hirschman, Arthur E. Uber, III, Kevin P. Cowan, David M. Reilly, Edward J. Rhinehart, John Kalafut, Bronwyn Uber, Frederick W. Trombley, III, Steven J. Remis, Paul D. Levin, Scott Griffith, Douglas Descalzi, Richard Dewit, David M. Griffiths
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Publication number: 20100185040Abstract: A system for injecting a patient, includes a container enclosing a hazardous pharmaceutical; a first pump to deliver a hazardous pharmaceutical to a patient and a fluid path operably connected to the first pump, the container, and the patient. The system further includes a hazardous material containment suitable to confine the hazardous pharmaceutical during connection of the hazardous pharmaceutical container to the fluid path.Type: ApplicationFiled: March 29, 2010Publication date: July 22, 2010Applicant: MEDRAD, INC.Inventors: Arthur E. Uber, III, Alan D. Hirschman, David M. Griffiths, Frederick W. Trombley, David M. Reilly
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Publication number: 20100174183Abstract: A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.Type: ApplicationFiled: November 28, 2007Publication date: July 8, 2010Applicant: MEDRAD, INC.Inventors: Robert S. Schwartz, Robert A. Van Tassel, Eugene A. Gelblum, Alan D. Hirschman, John F. Kalafut, David M. Reilly, Edward J. Rhinehart, Frederick W. Trombley, III, Arthur E. Uber, III
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Patent number: 7713239Abstract: A system for injecting a patient, includes a container enclosing a hazardous pharmaceutical; a first pump to deliver a hazardous pharmaceutical to a patient and a fluid path operably connected to the first pump, the container, and the patient. The system further includes a hazardous material containment suitable to confine the hazardous pharmaceutical during connection of the hazardous pharmaceutical container to the fluid path.Type: GrantFiled: April 8, 2004Date of Patent: May 11, 2010Assignee: Medrad, Inc.Inventors: Arthur E. Uber, III, Alan D. Hirschman, David M. Griffiths, Frederick W. Trombley, David M. Reilly
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Publication number: 20100114064Abstract: A system, includes a pressurizing mechanism to pressurize a fluid including a contrast enhancement agent for delivery to a patient; and a control system in operative connection with the pressurizing mechanism. The control system includes a system to adjust control of fluid injection based upon a measurement of renal function of the patient.Type: ApplicationFiled: November 3, 2009Publication date: May 6, 2010Applicant: MEDRAD, INC.Inventors: John F. Kalafut, Alan D. Hirschman, David M. Griffiths, Thomas P. Joyce, Jerry A. Stokes, Gerald W. Callan, Dennis P. Hack, Julie Gulick, Andreas R. Maihoefer, Arthur E. Uber, III
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Patent number: 7672710Abstract: A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.Type: GrantFiled: August 2, 2005Date of Patent: March 2, 2010Assignee: Medrad, Inc.Inventors: Arthur E. Uber, III, Edward J. Rhinehart, Rosemary Almon-Martin, David M. Griffiths, Alan D. Hirschman, Francis J. Sciulli, Walter Grumski, Karen Zelenski
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Publication number: 20090326370Abstract: A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.Type: ApplicationFiled: August 4, 2009Publication date: December 31, 2009Applicant: MEDRAD, INC.Inventors: Arthur E. Uber, III, Edward J. Rhinehart, Rosemary Almon-Martin, David M. Griffiths, Alan D. Hirschman, Francis J. Sciulli, Walter Grumski, Vera Pagano, Karen Zelenski
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Publication number: 20090240197Abstract: Systems, devices, and methods towards improved diagnosis and therapy in connection with central venous catheters (including PICC lines). Included among the many improvements broadly contemplated herein are: arrangements via which a venous catheter can move passively into position in central venous circulation; arrangements via which a catheter can be actively guided without the use of a needle or guide wire; arrangements via which a catheter can be packaged to facilitate easy, rapid, and positionally accurate deployment by medical personnel while maintaining device sterility; and arrangements via which a catheter tip can be imaged during and after insertion.Type: ApplicationFiled: April 19, 2007Publication date: September 24, 2009Applicant: Medrad, Inc.Inventors: Kevin P. Cowan, Eugene A. Gelblum, Alan D. Hirschman, David M. Reilly, Edward J. Rhinehart, Frederick W. Trombley, III
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Publication number: 20090012497Abstract: A system for delivering a slurry to a patient includes a fluid, a material that is non-dissolvable or immiscible in the fluid, thereby forming a slurry, a container adapted to contain the slurry and a supernate of the slurry, the container defining an outlet through which the slurry is delivered to the patient, a fluidizing system associated with the container, a pressurizing mechanism adapted to create a pressure to cause the slurry contained within the container to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system and the pressurizing mechanism. The fluidizing system is adapted to effect dilation of the slurry while maintaining at least a portion of the supernate.Type: ApplicationFiled: December 20, 2007Publication date: January 8, 2009Applicant: MEDRAD, INC.Inventors: Arthur E. Uber, III, David M. Griffiths, David M. Reilly, Alan D. Hirschman, Kevin P. Cowan, Mark Trocki
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Patent number: 7462166Abstract: A syringe for use with a powered injector to inject a fluid into a patient inclides an encoder. The encoder includes at least a first indicator positioned on the encoder. The first indicator is adapted to interact with at least a portion of energy being propagated through or adjacent the encoder in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.Type: GrantFiled: January 16, 2002Date of Patent: December 9, 2008Assignee: Medrad, Inc.Inventors: Kevin P. Cowan, Barry Iddon, Michael J. Yanniello, John A. Brosovich, Alan D. Hirschman
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Publication number: 20080294096Abstract: A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.Type: ApplicationFiled: November 6, 2006Publication date: November 27, 2008Applicant: Medrad Inc.Inventors: Arthur E. Uber, III, Alan D. Hirschman, Evan Facher, Eugene A. Gelblum, David M. Griffiths, Edward J. Rhinehart, David M. Reilly, Kevin P. Cowan, Page Cedarholm, Barry L. Tucker, Mark Trocki, David Mishler, Henry E. Bartony, JR., Robert Parks
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Publication number: 20080228104Abstract: A device for penetrating tissue and removing a biological sample includes a biological sampling element to remove a biological sample. The biological sampling element includes a passage therethrough. The device further includes a penetrator positioned within the passage. The penetrator is energized in a repetitive manner to assist in penetrating tissue. The biological sample element can be adapted to remove a tissue sample or a biological fluid sample (for example, blood). A device for penetrating tissue and positioning a tissue resident conduit (for example, a catheter), includes a tissue resident conduit (for example, a catheter) including a passage therethrough; and a penetrator in operative connection with the catheter. A device for inserting a tissue resident conduit includes at least one component that is energized during penetration to assist in penetrating tissue.Type: ApplicationFiled: March 11, 2005Publication date: September 18, 2008Inventors: Arthur E. Uber, David M. Griffiths, Alan D. Hirschman
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Publication number: 20080097339Abstract: In one form, the therapeutic agent delivery apparatus is used for infusing a therapeutic agent into a body lumen and includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a sensing element distal of the infusion ports and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen. In another form, the apparatus includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a filtration element distal of the infusion ports and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.Type: ApplicationFiled: August 31, 2006Publication date: April 24, 2008Applicant: Medrad, Inc.Inventors: Arun Ranchod, David M. Griffiths, Alan D. Hirschman
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Publication number: 20080086050Abstract: Hyperthermia has been applied by, for example, separate ultrasound transducers, RF or microwave transmitters and heated fluids. Imaging by separate MRI imaging coils is usually used to view the anatomical region under treatment. Separate temperature probes (needles, catheters) are often used to monitor tissue temperature. Control of the temperature profile required for effective hyperthermia treatment is usually done by trial and error, involving a human operator. The present invention combines all of these capabilities into a single device, which is MRI compatible and safe. It also allows for automatic control of the RF energy to achieve a prescribed tissue hyperthermia.Type: ApplicationFiled: October 8, 2007Publication date: April 10, 2008Applicant: MEDRAD, INC.Inventors: George J. Misic, Alan D. Hirschman
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Patent number: 7351221Abstract: A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.Type: GrantFiled: March 31, 2006Date of Patent: April 1, 2008Assignee: MEDRAD, Inc.Inventors: Frederick W. Trombley, III, Arthur E. Uber, III, Edward J. Rhinehart, Rosemary Almon-Martin, Alan D. Hirschman
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Publication number: 20080058758Abstract: In one form, the therapeutic agent delivery apparatus is used for infusing a therapeutic agent into a body lumen and includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a sensing element distal of the infusion ports and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen. In another form, the apparatus includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a filtration element distal of the infusion ports and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.Type: ApplicationFiled: August 22, 2007Publication date: March 6, 2008Applicant: MEDRAD, INC.Inventors: ARUN RANCHOD, David M. Griffiths, Alan D. Hirschman