Abstract: A method and apparatus are provided for die cutting label stock comprising a facestock, an adhesive and optionally a liner to form labels where a liner of the linered pressure sensitive adhesive label stock may be a thin or ultrathin liner.

Abstract: An automated beverage machine for vending of hot, cool and cold beverages including coffee, tea, chocolate, flavoured beverages, milk beverages and cold/iced beverages is shown in FIG. 1 at 100. The machine provides improved utility, with simplified on-site installation, sophisticated power management, content and machine condition sensing and highly automated cleaning and waste disposal requiring minimal operator intervention. A fully modular system using modules 110 allows minimisation of repair downtime, as both predictive and reactive maintenance can be instituted by removal and replacement of the designated module 110. The modular nature extends to the user interface provided on the front of the device which can be interchangeable allowing different “skins” to be presented. Optional automated and simplified cleaning allows minimal maintenance, and a highly automated and self cleaning internal waste removal system additionally reduces any downtime and user intervention requirements.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: A ladder system is disclosed which allows for stabilizing a ladder on multiple surfaces without the need for a second person or a great deal of setup time. The collapsible ladder system includes a larger ladder section and a smaller ladder strut section which are pivotally connected at a point which is at or below the midpoint of the larger ladder section. The larger ladder section and smaller ladder strut section are connected by a rigid adjustable linkage, or spreader, at a point that is below the pivotable connection. The ladder further includes a means for stability on a variety of surfaces. At the ground contact point, the point where the ladder side rail ends and the ground meet, there are adjustable gripping feet, which can be independently or in combination vertically or angularly adjusted for maximum stability.

Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: An apparatus and method for removing matrix material from a web of cut adhesive backed labels. A matrix stripping apparatus comprises a rotating cylinder for receiving a web of cut adhesive labels, a source for applying an electrostatic charge to the web of cut adhesive labels, and a separation member to facilitate separation of the matrix from a web comprising cut labels and a release liner. Applying an electrostatic charge to the web assists in holding the web against the rotating cylinder and relieves tension in the separation and removal of the matrix material.

Abstract: A method of quality of service (QoS) activation of customer premises equipment (CPE) associated with a network, includes activating classifiers associated with a switch port in the CPE, and determining when an associated IP address of the switch port is also activated, wherein the switch port classifier is activated only when the IP address of the switch port is also activated.

Abstract: A milk frothing device comprises a housing (2) including a container (10) for receiving the milk to be frothed, and a frothing means (20), wherein the container comprises a side wall (11), a bottom portion (13) and an inclined wall portion (12), wherein the inclined wall portion is inclined with respect to the side wall and is confined by the side wall and the bottom portion, wherein the container and the frothing means together form an asymmetrical arrangement.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.