Patent number: 6509366
Abstract: Disclosed are compounds of the formula:
or the pharmaceutically acceptable non-toxic salts thereof wherein Y, R1, R2, R3, R4, R5, R6, R7 R7′ are variables defined herein, which compounds are modulators of Bradykinin B2 receptors. These compounds are therefore useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatory disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility, glaucoma, pain, asthma, and rhinitis, and for the increase of permeability of the blood-brain barrier or the blood-brain-tumor barrier.
Type:
Grant
Filed:
January 17, 2001
Date of Patent:
January 21, 2003
Assignee:
Neurogen Corporation
Inventors:
Stanislaw Rachwal, Alan Hutchison, Kenneth Shaw, George D. Maynard, Xiao-shu He, Robert DeSimone, Kevin Hodgetts