Patent number: 6420365
Abstract: Disclosed are compounds of the formula:
or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R1, R3, R4, R5, and R6 are variables defined herein, which compounds are modulators of Bradykinin B2 receptors. These compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatory disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility, glaucoma, pain, asthma, and rhinitis and for the increase of permeability of the blood-brain barrier or the blood-brain-tumor barrier.
Type:
Grant
Filed:
January 17, 2001
Date of Patent:
July 16, 2002
Assignee:
Neurogen Corporation
Inventors:
John M. Peterson, Alan Hutchison, Kenneth Shaw, Kevin Hodgetts, George D. Maynard, Richard Lew
Patent number: 6358949
Abstract: Disclosed are compounds of the formula:
or the pharmaceutically acceptable non-toxic salts thereof wherein:
A, B, C and D are N or CH;
X is a bond or (un)substituted CH2;
R1 is lower alkenyl or (un)substituted lower alkyl;
R3 is lower alkyl; and
R2, R4, R5, and R6 are variables defined herein;
which compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatroy disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility or glaucoma, or for the increase of permeability of blood-brain barrier, pain, asthma, and rhinitis.
Type:
Grant
Filed:
March 31, 2000
Date of Patent:
March 19, 2002
Assignee:
Neurogen Corporation
Inventors:
Robert W. DeSimone, Alan Hutchison, Kenneth Shaw, George D. Maynard, John M. Peterson, Richard Lew, Harry L. Brielmann