Patents by Inventor Alan P. Escher

Alan P. Escher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210085771
    Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.
    Type: Application
    Filed: September 9, 2020
    Publication date: March 25, 2021
    Inventor: Alan P. Escher
  • Patent number: 10813987
    Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: October 27, 2020
    Assignee: Loma Linda University
    Inventor: Alan P. Escher
  • Publication number: 20200316180
    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
    Type: Application
    Filed: November 6, 2019
    Publication date: October 8, 2020
    Inventors: Fengchun Li, Alan P. Escher
  • Patent number: 10500258
    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: December 10, 2019
    Assignee: Loma Linda University
    Inventors: Fengchun Li, Alan P. Escher
  • Publication number: 20170028039
    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
    Type: Application
    Filed: June 3, 2016
    Publication date: February 2, 2017
    Inventors: Fengchun Li, Alan P. Escher
  • Patent number: 9358277
    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: June 7, 2016
    Assignee: Loma Linda University
    Inventors: Fengchun Li, Alan P. Escher
  • Publication number: 20140286871
    Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.
    Type: Application
    Filed: September 21, 2012
    Publication date: September 25, 2014
    Inventor: Alan P. Escher
  • Publication number: 20140288164
    Abstract: Compositions can be used to stimulate growth of a hair shaft from a hair follicle. These compositions can include methylated polynucleotides useful in treatment of autoimmune diseases or conditions, including those, such as alopecia areata, that result in hair loss.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Applicant: Loma Linda University
    Inventor: Alan P. ESCHER
  • Publication number: 20140220048
    Abstract: Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs downregulates the expression of the target gene in living cells.
    Type: Application
    Filed: December 20, 2013
    Publication date: August 7, 2014
    Applicant: Loma Linda University
    Inventors: Fengchun Li, Alan P. Escher
  • Patent number: 8778327
    Abstract: A substance or a composition for preventing, delaying the onset of or treating one or more than one immune-mediated inflammatory disorder in an organism who is susceptible to developing the immune-mediated inflammatory disorder, who is developing the immune-mediated inflammatory disorder or who has the immune-mediated inflammatory disorder. A method of preventing, delaying the onset of or treating an organism who is susceptible to developing the immune-mediated inflammatory disorder, who is developing the immune-mediated inflammatory disorder or who has the immune-mediated inflammatory disorder.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: July 15, 2014
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Fengchun Li
  • Patent number: 8637476
    Abstract: Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs downregulates the expression of the target gene in living cells.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: January 28, 2014
    Assignee: Loma Linda University
    Inventors: Fengchun Li, Alan P. Escher
  • Publication number: 20120308577
    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipeint, as described herein, can induce a donor specific tolerogenic response.
    Type: Application
    Filed: July 6, 2012
    Publication date: December 6, 2012
    Applicant: LOMA LINDA UNIVERSITY
    Inventors: Fengchun Li, Alan P. Escher
  • Publication number: 20100068813
    Abstract: Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs downregulates the expression of the target gene in living cells.
    Type: Application
    Filed: September 28, 2007
    Publication date: March 18, 2010
    Applicant: LOMA LINDA UNIVERSITY
    Inventors: Fengchun Li, Alan P. Escher
  • Patent number: 7638498
    Abstract: A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoimmune disease or who has the autoimmune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding ?BCL-2.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: December 29, 2009
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Fengchun Li
  • Publication number: 20090191218
    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
    Type: Application
    Filed: March 23, 2009
    Publication date: July 30, 2009
    Inventors: Fengchun Li, Alan P. Escher
  • Publication number: 20080194510
    Abstract: A substance or a composition for preventing, delaying the onset of or treating one or more than one immune-mediated inflammatory disorder in an organism who is susceptible to developing the immune-mediated inflammatory disorder, who is developing the immune-mediated inflammatory disorder or who has the immune-mediated inflammatory disorder. A method of preventing, delaying the onset of or treating an organism who is susceptible to developing the immune-mediated inflammatory disorder, who is developing the immune-mediated inflammatory disorder or who has the immune-mediated inflammatory disorder.
    Type: Application
    Filed: May 5, 2006
    Publication date: August 14, 2008
    Applicant: LOMA LINDA UNIVERSITY
    Inventors: Alan P. Escher, Fengchun Li
  • Publication number: 20080171713
    Abstract: A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoimmune disease or who has the autoimmune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding ?BCL-2.
    Type: Application
    Filed: August 9, 2007
    Publication date: July 17, 2008
    Applicant: LOMA LINDA UNIVERSITY
    Inventors: Alan P. Escher, Fengchun Li
  • Publication number: 20080171714
    Abstract: A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoimmune disease or who has the autoimmune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding ?BCL-2.
    Type: Application
    Filed: August 9, 2007
    Publication date: July 17, 2008
    Applicant: LOMA LINDA UNIVERSITY
    Inventors: Alan P. Escher, Fengchun Li
  • Patent number: 7381711
    Abstract: A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoinimune disease or who has the autoinimune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding ?BCL-2.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: June 3, 2008
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Fengchun Li
  • Patent number: 6995147
    Abstract: A method for preventing, delaying the onset of or treating diabetes in a patient comprising selecting a patient who is susceptible to developing diabetes, who is developing diabetes or who is diabetic and administering to the patient one or more than one dose of a pharmaceutical agent comprising a polynucleotide encoding a secreted exogenous protein, such as a secreted luciferase or a secreted form of human glutamic acid decarboxylase.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: February 7, 2006
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Jingxue Liu