Patents by Inventor Alan P. Escher

Alan P. Escher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substances for preventing and treating autoimmune diseases
    Patent number: 7381711
    Abstract: A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoinimune disease or who has the autoinimune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding ?BCL-2.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: June 3, 2008
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Fengchun Li
  • Method of delaying the onset of diabetes
    Patent number: 6995147
    Abstract: A method for preventing, delaying the onset of or treating diabetes in a patient comprising selecting a patient who is susceptible to developing diabetes, who is developing diabetes or who is diabetic and administering to the patient one or more than one dose of a pharmaceutical agent comprising a polynucleotide encoding a secreted exogenous protein, such as a secreted luciferase or a secreted form of human glutamic acid decarboxylase.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: February 7, 2006
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Jingxue Liu
  • Secreted renilla luciferase
    Patent number: 6451549
    Abstract: A polynucleotide encoding a secreted form of wild type Renilla luciferase. Also provided is a polynucleotide encoding a secreted modified form of wild type Renilla luciferase. Additionally, the polypeptides encoded by the polynucleotides of the present invention and uses of the polynucleotides and polypeptides of the present invention in biological assays. Also, a stable mammalian packaging cell line which produces retroviruses carrying a polynucleotide encoding a secreted Renilla luciferase.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: September 17, 2002
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Jingxue Liu
  • Secreted renilla luciferase
    Publication number: 20020081644
    Abstract: A polynucleotide encoding a secreted form of wild type Renilla luciferase. Also provided is a polynucleotide encoding a secreted modified form of wild type Renilla luciferase. Additionally, the polypeptides encoded by the polynucleotides of the present invention and uses of the polynucleotides and polypeptides of the present invention in biological assays. Also, a stable mammalian packaging cell line which produces retroviruses carrying a polynucleotide encoding a secreted Renilla luciferase.
    Type: Application
    Filed: March 14, 2001
    Publication date: June 27, 2002
    Inventors: Alan P. Escher, Jingxue Liu
  • Secreted renilla luciferase
    Patent number: 6228604
    Abstract: A polynucleotide encoding a secreted form of wild type Renilla luciferase. Also provided is a polynucleotide encoding a secreted modified form of wild type Renilla luciferase. Additionally, the polypeptides encoded by the polynucleotides of the present invention and uses of the polynucleotides and polypeptides of the present invention in biological assays. Also, a stable mammalian packaging cell line which produces retroviruses carrying a polynucleotide encoding a secreted Renilla luciferase.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: May 8, 2001
    Assignee: Loma Linda University
    Inventors: Alan P. Escher, Jingxue Liu