Abstract: An accessory support assembly for a vehicle seat includes a support frame that includes an upper bracket and a lower bracket coupled to a bottom of the upper bracket. The lower bracket includes coupling features. The lower bracket defines side projections that extend from opposing sides of the support frame. A speaker assembly is coupled to the support frame. The speaker assembly includes a first speaker housing and a second speaker housing. The first and second speaker housings are coupled to the side projections of the support frame, respectively. A speaker is disposed in each of the first and second housings.

Abstract: Provided herein are interleukin 7 (IL-7) binding proteins, pharmaceutical compositions and their use in the treatment or prevention of a disease or condition.

Abstract: An accessory support assembly for a vehicle seat includes a support frame that includes an upper bracket and a lower bracket coupled to a bottom of the upper bracket. The lower bracket includes coupling features. The lower bracket defines side projections that extend from opposing sides of the support frame. A speaker assembly is coupled to the support frame. The speaker assembly includes a first speaker housing and a second speaker housing. The first and second speaker housings are coupled to the side projections of the support frame, respectively. A speaker is disposed in each of the first and second housings.

Abstract: The present invention relates to methods of selecting, screening, engineering, making and modifying antibodies that have improved bioavailability upon subcutaneous administration to a human. Antibodies and variant antibodies with improved bioavailability upon subcutaneous administration to a human are also described.

Abstract: The present invention relates to TrkB binding agonists, and to the use of such agonists in the treatment of neurological disorders and other disorders. The present invention also relates to specific TrkB binding agonists comprising CDRs, variable regions, heavy and light chains, and variant sequences thereof.

Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.

Abstract: A system and method for measuring dynamic properties of a structure, and for using the measured dynamic properties to assess the dynamic performance of the structure. The system and method can separate the measured response into low amplitude and high amplitude data to reduce the influence of outside forces and mass. The system and method measures dynamic properties of the structure such as frequencies of resonance, mode shapes, and non-linear damping, and uses them in an analysis of the structure to compare the dynamic response of the structure with the anticipated properties of a structure built according to applicable building code requirements. The system and method thus quantifies a risk of failure of the structure by determining a risk ratio that compares an as-is condition of the structure with an as-designed condition of the structure.

Abstract: The present invention relates to TrkB binding agonists, and to the use of such agonists in the treatment of neurological disorders and other disorders. The present invention also relates to specific TrkB binding agonists comprising CDRs, variable regions, heavy and light chains, and variant sequences thereof.

Abstract: Embodiments may relate to an audio system for playback of an audio signal, for example in a motor vehicle. The audio system may include a virtualization speaker located in a position that would be in front of a listener of the audio system. The audio system may further include a user speaker located in a position that would be behind a listener of the audio system. In some embodiments the virtualization speaker may be configured to play a virtualization audio signal while the user speakers are configured to play an audio signal which at least partially overlaps the virtualization audio signal. In some embodiments the virtualization audio signal may be at a different volume or a different frequency range than the audio signal. Other embodiments may be described or claimed.

Abstract: The present disclosure relates to compositions comprising antibody variants, for treating interleukin 5 (IL-5) mediated diseases, and related methods.

Abstract: Disclosed herein is an apparatus for aiding in mounting strings to an instrument, which includes a frame having: a pair of opposing extension members, a cross-member connecting the opposing extension members at a distal end; and a support member extending laterally from each of the opposing extension members. The apparatus also includes a retention assembly and a tensile retaining mechanism supported about the cross-member and extending toward the neck portion of the musical instrument. The tensile retaining mechanism including clip member wherein the clip member of the tensile retaining mechanism is configured to receive a string for mounting to the instrument, the tensile retaining mechanism configured to maintain a desired lateral position along the neck portion and maintain a tensile force to the string during a tightening process.

Abstract: A system and method for measuring dynamic properties of a structure, and for using the measured dynamic properties to assess the dynamic performance of the structure. The system and method measures dynamic properties of the structure such as frequencies of resonance, mode shapes, and non-linear damping, and uses them in an analysis of the structure to compare the dynamic response of the structure with the anticipated properties of a structure built according to applicable building code requirements. The system and method thus quantifies a risk of failure of the structure by determining a risk ratio that compares an as-is condition of the structure with an as-designed condition of the structure.

Abstract: An apparatus and method of securing an elongate member to a medical instrument. The apparatus comprising an attachment device including a base, a liner, and an adhesive. The base comprising an aperture configured to receive the elongate member, wherein the liner may be positioned adjacent the aperture and axially aligned with the elongate member when the attachment device is coupled to the medical instrument. The attachment device may comprise a pair of apertures and the liner may be positioned adjacent the adhesive and at least partially between the pair of apertures. The method of securing the elongate member to the medical instrument comprises threading the elongate member through the aperture of the attachment device and adhering the attachment device to the medical instrument. The method of manufacturing the attachment device may comprise cutting the aperture in the base, the adhesive, and liner.

Abstract: The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains e.g. human immunoglobulin (antibody) single variable domains, and also single variable domains derived from non-human sources such as a llama or camel, e.g. a VHH including a Nanobody™ (described in e.g. WO 94/04678 and WO 95/04079 inter alia). The invention further relates to uses, formulations, compositions comprising such modified C terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these molecules.

Abstract: Many different types of systems are utilized or tasks are performed in a marine environment. The present invention provides various configurations of unmanned vehicles, or drones, that can be operated and/or controlled for such systems or tasks. One or more unmanned vehicles can be integrated with a dedicated marine electronic device of a marine vessel for autonomous control and operation. Additionally or alternatively, the unmanned vehicle can be manually remote operated during use in the marine environment. Such unmanned vehicles can be utilized in many different marine environment systems or tasks, including, for example, navigation, sonar, radar, search and rescue, video streaming, alert functionality, among many others. However, as contemplated by the present invention, the marine environment provides many unique challenges that may be accounted for with operation and control of an unmanned vehicle.

Abstract: The present invention relates to methods of selecting, screening, engineering, making and modifying antibodies that have improved bioavailability upon subcutaneous administration to a human. Antibodies and variant antibodies with improved bioavailability upon subcutaneous administration to a human are also described.

Abstract: The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

Abstract: Disclosed herein is an apparatus for aiding in mounting strings to an instrument, which includes a frame having: a pair of opposing extension members, a cross-member connecting the opposing extension members at a distal end; and a support member extending laterally from each of the opposing extension members. The apparatus also includes a retention assembly and a tensile retaining mechanism supported about the cross-member and extending toward the neck portion of the musical instrument. The tensile retaining mechanism including clip member wherein the clip member of the tensile retaining mechanism is configured to receive a string for mounting to the instrument, the tensile retaining mechanism configured to maintain a desired lateral position along the neck portion and maintain a tensile force to the string during a tightening process.

Abstract: Many different types of systems are utilized or tasks are performed in a marine environment. The present invention provides various configurations of unmanned vehicles, or drones, that can be operated and/or controlled for such systems or tasks. One or more unmanned vehicles can be integrated with a dedicated marine electronic device of a marine vessel for autonomous control and operation. Additionally or alternatively, the unmanned vehicle can be manually remote operated during use in the marine environment. Such unmanned vehicles can be utilized in many different marine environment systems or tasks, including, for example, navigation, sonar, radar, search and rescue, video streaming, alert functionality, among many others. However, as contemplated by the present invention, the marine environment provides many unique challenges that may be accounted for with operation and control of an unmanned vehicle.

Abstract: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.