Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.

Abstract: The present invention provides novel antigen-binding proteins derived from human germline VH domains, having improved expression and improved biophysical characteristics.

Abstract: The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such humanised antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.

Abstract: An information handling apparatus in which textual metadata is generated in respect of a current information item in an ensemble of information items including: a mechanism that detects one or more predetermined properties of the current information item; a mechanism that detects a subset of information items from the ensemble of information items the subset being those which have the one or more predetermined properties most similar to those of the current information item; and a mechanism that selects one or more most frequently occurring words and/or phrases within textual metadata associated with the subset of information items, for use in textual metadata to be associated with the current information item.

Abstract: A system for managing and exchanging electronic information provides a rules management component for executing conceptual rules, an ontology management component, an information model management component, and a system configuration management component. The ontology management component manages at least one ontology and mappings between members of different ontologies. The ontologies may include a code system and a terminology. The ontology management component may manage a value set that is a subset of the terminology. The information model management component manages one or more information model schemas, each defining an information model and comprising information defining at least one slot within the information model. The system configuration management component manages configuration information on the configuration of each system component.

Abstract: An interactive input system comprises an interactive surface; at least one proximity sensor in proximity with the interactive surface and generating output signifying user proximity to the interactive surface; and processing structure configured to process user input generated in response to user interaction with said interaction input system and output from the at least one proximity sensor, said processing structure controlling interactive input system operation based upon at least one of said user input and proximity sensor output.

Abstract: The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases

Abstract: Aluminum, boron and silicon were identified as potential leachables from borosilicate glassware and a silica based QMA during handling of aqueous 18F. The addition of only 0.4 ppm aluminum as AlCl3 in the eluent vial resulted in a strong reduction in the labeling yield of a model [18F]fluoride SN2 reaction (from 80 to 40% incorporation). The addition of boron as KBO2 and silicon as NaSiO3 did not result in any significant decrease in labeling yield. Interestingly, there was an interaction effect between AlCl3 and KBO2 in which the negative effect from AlCl3 on labeling yield was counteracted by KBO2. The present invention demonstrates that aluminum and boron from borosilicate glassware have a strong influence on the labeling yield in nucleophilic SN2 reactions with n.c.a [18F]fluoride.

Abstract: A method of promoting neural cell regeneration is carried out by contacting a neural cell with a compound that inhibits the binding of a chondroitin sulfate proteoglycan (CSPG) to a cellular (e.g., trans-membrane) PTP? protein. The neural cell is associated with an injury or neurodegenerative condition.

Abstract: The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes.

Abstract: The present invention claims a method for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. The present invention also provides for an apparatus for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. Kit claims for formation of [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species are also provided.

Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).

Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.

Abstract: The present invention relates to a method of electrochemically desorbing or adsorbing a cryptate [18F] fluoride complex using a substituent substituted cryptand A. The present invention also relates to an apparatus and a kit for performing this method. A: which can be used for nucleophilic radiofluorination.

Abstract: The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.

Abstract: A method for mitigating against a clutter source or other interferer in a high precision radar is disclosed. The clutter source or interferer may be a wind farm. The method includes positioning a plurality of relatively low resolution radars, such as low cost marine navigation radars, in or about the interferer, and fusing data from them together, to produce object positional data of increased accuracy. One or more of the radars may be adapted to have a radiation beam pattern directed more towards the vertical, and such adapted radars may advantageously be located more centrally within the interfering region. Data from the individual radars may be fused in any suitable manner, and other information, such as ADS-B broadcasts may be included. Data relating to aircraft may be supplied to operators to supplement air traffic control, and air defence radars, and data relating to shipping around sea based wind farms supplied to vessel traffic system radar operators.

Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).