Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate drive member and a tissue-removing element operatively coupled to the distal end portion of the elongate drive member. An inner liner received within the drive coil defines a liner passage sized and shaped to receive a guidewire therein. A distal tip extends distally outward from the tissue-removing element. The distal tip has a proximal end portion disposed within the tissue-removing element and a distal end portion spaced distally from the tissue-removing element. A distal end portion of the inner liner is axially spaced apart from the proximal end portion of the distal tip such that the distal tip is free from direct connection to the inner liner.

Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate catheter body. A tissue-removing element is operatively coupled to a distal end portion of the elongate catheter body. The tissue-removing element has a central axis. The tissue-removing element is configured to be rotated about its central axis to remove tissue from the body lumen. A distal end portion of the tissue-removing element includes a distal end face at a distal-most end of the tissue-removing element. The distal end face has a perimeter and a diameter extending through the central axis. Diametrically opposite points on the perimeter lie in a plane that is oblique to the central axis of the tissue-removing element.

Abstract: The present disclosure provides a tissue-removing catheter that includes an elongate body with proximal and distal end portions, a tissue-removing element, an inner liner, and a coupling assembly. The tissue-removing element removes tissue by rotation from the elongate body. The inner liner defines a guidewire lumen received within the elongate body and is coupled to the tissue-removing element at its distal end portion. The coupling assembly includes a bushing attached to the distal end portion of the inner liner and a bearing disposed around the bushing with an exterior surface of the bushing contacting an interior surface of the bearing along less than 50% of an internal surface area of the interior surface of the bearing. At least one of the exterior surface of the bushing and the interior surface of the bearing may define a non-uniform dimension extending along a length of one of the bushing and bearing.

Abstract: A debulking catheter includes an advancer for advancing a tissue-removing clement, and a linear-force indicator. The linear-force indicator provides feedback to the user based on an amount of linear force being applied to the advancer.

Abstract: An implantable medical device, and a method of manufacturing the same, the device including a bioresorbable conduit including an exterior surface including one or more weakened areas configured to degrade preferentially to the remainder of the bioresorbable conduit, and an interior surface.

Abstract: A debulking catheter includes an advancer for advancing a tissue-removing element, and a linear-force indicator. The linear-force indicator provides feedback to the user based on an amount of linear force being applied to the advancer.

Abstract: The present disclosure provides a tissue-removing catheter for removing tissue in a body lumen. The tissue-removing catheter includes an elongate drive member and a tissue-removing element. The elongate drive member has proximal and distal ends with a length and a longitudinal axis extending between the proximal and distal ends. The elongate drive member is sized and shaped to be received in the body lumen and rotates about its longitudinal axis. The elongate drive member further includes first and second longitudinal portions. The first longitudinal portion is proximal to and stiffer than the second longitudinal portion. The tissue-removing element is operatively coupled to the distal end of the elongate drive member and rotates by the elongate drive member to remove the tissue in the body lumen.

Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate drive member and a tissue-removing element operatively coupled to the distal end portion of the elongate drive member. An inner liner received within the drive coil defines a liner passage sized and shaped to receive a guidewire therein. A distal tip extends distally outward from the tissue-removing element. The distal tip has a proximal end portion disposed within the tissue-removing element and a distal end portion spaced distally from the tissue-removing element. A distal end portion of the inner liner is axially spaced apart from the proximal end portion of the distal tip such that the distal tip is free from direct connection to the inner liner.

Abstract: A collagen scaffold for the delivery of bioactive agents such as antimicrobials comprising a first collagen matrix layer and a second collagen matrix layer in which the first collagen matrix layer comprises a first bioactive agent physically entrapped in the first collagen matrix layer and the second collagen matrix layer comprises a second bioactive agent chemically attached to the second collagen matrix layer for an initial high concentration elution of antimicrobial from the first collagen matrix layer followed by a sustained release from the second collagen matrix layer to prevent re-infection.

Abstract: The present disclosure provides a tissue-removing catheter that includes an elongate body, a tissue-removing element, and an inner liner. The elongate body has proximal and distal end portions spaced apart from one another along an axis and is sized and shaped to be received in a body lumen. The tissue-removing element rotates by the elongate body to remove tissue. The inner liner is received within the elongate body, defines a guidewire lumen, and isolates an interior of the guidewire lumen from the elongate body and tissue-removing element, preventing torsional force from transferring from the elongate body and tissue-removing element to the interior of the guidewire lumen. The inner liner includes a distal end margin that may have a construction different from a construction of a second portion of the inner liner proximal of the distal end margin. The distal end margin may be more flexible than the second portion.

Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate catheter body. A tissue-removing element is operatively coupled to a distal end portion of the elongate catheter body. The tissue-removing element has a central axis. The tissue-removing element is configured to be rotated about its central axis to remove tissue from the body lumen. A distal end portion of the tissue-removing element includes a distal end face at a distal-most end of the tissue-removing element. The distal end face has a perimeter and a diameter extending through the central axis. Diametrically opposite points on the perimeter lie in a plane that is oblique to the central axis of the tissue-removing element.

Abstract: The present disclosure provides a tissue-removing catheter that includes an elongate body with proximal and distal end portions, a tissue-removing element, an inner liner, and a coupling assembly. The tissue-removing element removes tissue by rotation from the elongate body. The inner liner defines a guidewire lumen received within the elongate body and is coupled to the tissue-removing element at its distal end portion. The coupling assembly includes a bushing attached to the distal end portion of the inner liner and a bearing disposed around the bushing with an exterior surface of the bushing contacting an interior surface of the bearing along less than 50% of an internal surface area of the interior surface of the bearing. At least one of the exterior surface of the bushing and the interior surface of the bearing may define a non-uniform dimension extending along a length of one of the bushing and bearing.

Abstract: A debulking catheter includes an advancer for advancing a tissue-removing element, and a linear-force indicator. The linear-force indicator provides feedback to the user based on an amount of linear force being applied to the advancer.

Abstract: An apparatus is provided for applying a covering film to a book. The apparatus has a gate mechanism having open and closed states, which in the closed state presents a front surface against which a covering film may be overlaid. The spine of a book is pressed onto the covering film overlaying the front surface. The gate is then opened to admit the book to a space rearward of the gate beyond the front surface, such that the book draws the covering film into that space. A laminating mechanism is positioned rearwardly of the gate top receive the book and laminate the film against the front and rear covers to cover the book with the film.

Abstract: A process for removing hazardous substances from a LCD display (1) includes incision through off set lines (10) around the front of the panel (3). Top components are then removed to expose the fluorescent tubes (5) which contain hazardous substances. The incisions are parallel to the recessed lips, at a distance in the range of 0 to 20 mm from the recessed lips. The cuts are to a depth of 20 mm to 50 mm. Preferably, at least two incisions are made simultaneously. The fluorescent tubes (5) are crushed after the access operation, by rollers, chains or by plates. During crushing there is suction of the particles and gases which are released, thereby removing the hazardous substances by filtration.

Abstract: A process for removing hazardous substances from a LCD display (1) includes incision through off set lines (10) around the front of the panel (3). Top components are then removed to expose the fluorescent tubes (5) which contain hazardous substances. The incisions are parallel to the recessed lips, at a distance in the range of 0 to 20 mm from the recessed lips. The cuts are to a depth of 20 mm to 50 mm. Preferably, at least two incisions are made simultaneously. The fluorescent tubes (5) are crushed after the access operation, by rollers, chains or by plates. During crushing there is suction of the particles and gases which are released, thereby removing the hazardous substances by filtration.

Abstract: The present invention is directed to an oral dosage form comprising a gel capsule comprising, (a) plasticizer; (b) gelatin; (c) water; and (d) greater than 850 mg DHA ethyl ester, wherein less than about 2% (wt/wt) of the total fatty acid content of the dosage form is EPA, wherein the total weight of the capsule is about 1 g and wherein the capsule is stable at about 25° C. at 60% relative humidity.