Patents by Inventor Alan T. Johnson, Jr.

Alan T. Johnson, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11846622
    Abstract: Provided are aptamer-functionalized graphene sensors, capable of detecting various analytes, including toxins, at comparatively low concentrations. Also provided are methods of fabricating and using such aptamer-functionalized graphene sensors.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: December 19, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Jinglei Ping, Steven Vitale, Chengyu Wen
  • Publication number: 20230337358
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Application
    Filed: October 19, 2022
    Publication date: October 19, 2023
    Inventors: Alan T. Johnson, JR., Rajatesh R. Gudibande, Zhengqing John Qi
  • Publication number: 20230055137
    Abstract: Provided are devices and methods for detecting a target molecule, based on using a graphene electrode. The devices exhibit high sensitivity to target molecules such as DNA that may be present at comparatively low concentrations.
    Type: Application
    Filed: September 22, 2022
    Publication date: February 23, 2023
    Inventors: Alan T. JOHNSON, JR., Jinglei PING, Ramya VISHNUBHOTLA
  • Publication number: 20230051545
    Abstract: Provided are devices and methods for a rapid, non-perturbative and energy-efficient technique for pH sensing based on a flexible graphene electrode. This technique does not require the application of gate voltage or source-drain bias, and demonstrates fast pH-characterization with precision. The disclosed technology is suitable for in vivo monitoring of tumor-induced pH variation in tissues and detection of pH changes as required in a DNA sequencing system.
    Type: Application
    Filed: April 1, 2022
    Publication date: February 16, 2023
    Inventors: Alan T. Johnson, JR., Jinglei Ping
  • Patent number: 11546987
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: January 3, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T Johnson, Jr., Rajatesh R Gudibande, Zhengqing John Qi
  • Patent number: 11327041
    Abstract: Provided are devices and methods for a rapid, non-perturbative and energy-efficient technique for pH sensing based on a flexible graphene electrode. This technique does not require the application of gate voltage or source-drain bias, and demonstrates fast pH-characterization with precision. The disclosed technology is suitable for in vivo monitoring of tumor-induced pH variation in tissues and detection of pH changes as required in a DNA sequencing system.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: May 10, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Jinglei Ping
  • Publication number: 20220078908
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Application
    Filed: March 25, 2021
    Publication date: March 10, 2022
    Inventors: Alan T Johnson, Jr., Rajatesh R Gudibande, Zhengqing John Qi
  • Publication number: 20220011302
    Abstract: Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a bio-molecule that preferentially binds to a particular analyte.
    Type: Application
    Filed: September 13, 2021
    Publication date: January 13, 2022
    Inventors: Alan T. Johnson, JR., Ye Lu, Joseph J. Mitala, JR., Bohdana Discher, Brett R. Goldsmith
  • Patent number: 11119097
    Abstract: Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a biomolecule that preferentially binds to a particular analyte.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: September 14, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Ye Lu, Joseph J. Mitala, Bohdana Discher, Brett R. Goldsmith
  • Patent number: 10983117
    Abstract: Disclosed are devices that comprise a protein, such as an antibody, placed into electronic communication with a semiconductor material, such as a carbon nanotube. The devices are useful in assessing the presence or concentration of analytes contacted to the devices, including the presence of markers for prostate cancer and Lyme disease.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: April 20, 2021
    Assignees: The Trustees of the University of Pennsylvania, The Institute For Cancer Research
    Inventors: Alan T. Johnson, Jr., Mitchell Lerner, Matthew W. Robinson, Tatiana Pazina, Dustin Brisson, Jennifer Dailey, Brett R. Goldsmith
  • Publication number: 20210048407
    Abstract: Provided are electronic biosensors based on graphene field effect transistors that utilize engineered hairpin probe DNA that allows for target recycling and hybridization chain reactions.
    Type: Application
    Filed: March 8, 2019
    Publication date: February 18, 2021
    Inventors: Alan T. JOHNSON, Jr., Zhaoli GAO, Han XIA
  • Patent number: 10900971
    Abstract: The present invention provides biomimetic sensor devices that utilize proteins—such G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: January 26, 2021
    Assignees: The Trustees of the University of Pennsylvania, The Board of Trustees of the University of Illinois
    Inventors: Alan T. Johnson, Jr., Brett R. Goldsmith, Joseph J. Mitala, Jr., Bohdana M. Discher, Stephen G. Sligar, Timothy H. Bayburt
  • Publication number: 20200170108
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 28, 2020
    Inventors: Alan T. Johnson, JR., Rajatesh R. Gudibande, Zhengqing John Qi
  • Publication number: 20190339246
    Abstract: Provided are aptamer-functionalized sensors, capable of detecting various analytes, including toxins, at comparatively low concentrations. Also provided are methods of fabricating and using such sensors.
    Type: Application
    Filed: March 12, 2019
    Publication date: November 7, 2019
    Inventors: Alan T Johnson, JR., Jinglei Ping
  • Publication number: 20190113474
    Abstract: A method of fracturing a subterranean formation penetrated by a well comprises: combining an aqueous carrier with a superabsorbent polymer and a borated galactomannan to form a hydraulic fracturing composition; and pumping the hydraulic fracturing composition into the well.
    Type: Application
    Filed: March 13, 2017
    Publication date: April 18, 2019
    Inventors: Alan T. Johnson, Jr., Jinglei PING, Ramya VISHNUBHOTLA
  • Publication number: 20190116666
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Application
    Filed: December 10, 2018
    Publication date: April 18, 2019
    Inventors: Alan T. Johnson, JR., Rajatesh R. Gudibande, Zhengqing John Qi
  • Publication number: 20190079043
    Abstract: Provided are devices and methods for a rapid, non-perturbative and energy-efficient technique for pH sensing based on a flexible graphene electrode. This technique does not require the application of gate voltage or source-drain bias, and demonstrates fast pH-characterization with precision. The disclosed technology is suitable for in vivo monitoring of tumor-induced pH variation in tissues and detection of pH changes as required in a DNA sequencing system.
    Type: Application
    Filed: March 13, 2017
    Publication date: March 14, 2019
    Inventors: Alan T. Johnson, Jr., Jinglei PING
  • Patent number: 10168297
    Abstract: The present invention provides a broad response single-stranded DNA-graphene chemical sensor device. The present invention also provides methods for improving the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: January 1, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Ye Lu, Brett R. Goldsmith, Nicholas J. Kybert
  • Patent number: 10165679
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: December 25, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Rajatesh R. Gudibande, Zhengqing John Qi
  • Publication number: 20180160530
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 7, 2018
    Inventors: Alan T. JOHNSON, JR., Rajatesh R. GUDIBANDE, Zhengqing John QI