Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: An electronic device comprises a stack of alternating dielectric materials and conductive materials, a pillar region extending vertically through the stack, an oxide material within the pillar region and laterally adjacent to the dielectric materials and the conductive materials of the stack, and a storage node laterally adjacent to the oxide material and within the pillar region. A charge confinement region of the storage node is in horizontal alignment with the conductive materials of the stack. A height of the charge confinement region in a vertical direction is less than a height of a respective, laterally adjacent conductive material of the stack in the vertical direction. Related methods and systems are also disclosed.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: An actuated telescoping system for navigation within a vascular lumen and thrombectomy of a thrombus. The system includes a tubular catheter member having an open distal end defining a catheter lumen, a vacuum source, a rotational drive system, a flexible shaft having a channel coupled to the rotational drive system for rotational movement in response thereto, and an optional guidewire selectively inserted at least partially within the flexible shaft. The flexible shaft is at least partially disposed within the tubular catheter member configured for uncoupled rotational and translational motion therein and to optionally define a corkscrew motion in response to rotational driving force by the drive system that results in formation of hydrodynamic vortices within the catheter lumen.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: The present disclosure describes materials, methods, and systems for three-dimensional printing. In one example, a three-dimensional printing kit can include a fusing agent and a microbe-inhibiting agent. The fusing agent can include water and an electromagnetic radiation absorber. The electromagnetic radiation absorber can absorb radiation and convert the radiation energy to heat. The microbe-inhibiting agent can include a liquid vehicle and a metal bis(dithiolene) complex. The disclosure also describes methods of three-dimensional printing that utilize a metal-containing microbe-inhibiting material, which can be a metal bis(dithiolene) complex or other materials.

Abstract: A scalable power unit for powering one or more electric motors of a riding vehicle and/or a piece of outdoor power equipment includes a number of interconnected battery packs. The battery pack are received in a battery tray or stacked to form the scalable power unit. Each battery pack is configured to be removed and used separately or added to a combination of battery packs. A control unit selectively opens and closes switching elements to separately control the connections between the battery packs and an electrical load, such as a motor. During charging, the control unit opens and closes switching elements to control the charging rate of the individual battery packs. When the battery packs are connected to an electrical load, the control unit controls the state of the switching elements to selectively discharge the battery packs to power the riding vehicle and/or electric loads.

Abstract: A riding lawn mower comprising, a pair of rear drive wheels, a pair of front wheels, a deck positioned between the pair of front wheels and the pair of rear drive wheels, a rotatable cutting blade, and multiple battery packs removably coupled to the riding lawn mower and structured to provide power to the riding lawn mower, each battery pack graspable and removable by a user, wherein the multiple battery packs sequentially provide power to the riding lawn mower.

Abstract: Embodiments of the present application provide a status detection method and apparatus for a filter. The filter filters a fluid in a sealed channel. At least a pressure sensor is further provided downstream of the filter in the sealed channel. The method includes: if a fluid flowing through a filter in a sealed channel is controlled to have a first flow rate, then acquiring a first pressure value measured by a pressure sensor; if the fluid flowing through the filter in the sealed channel is controlled to have a second flow rate, then acquiring a second pressure value measured by the pressure sensor; and determining a status of the filter according to a difference between the first pressure value and the second pressure value. Therefore, detection of the status of the filter is achieved, and an operator is prompted to maintain/replace the filter in time. In addition, an existing component can be used, so that applicability is high and detection costs are low.

Abstract: A riding lawn mower comprising, a pair of rear drive wheels, a pair of front wheels, a deck positioned between the pair of front wheels and the pair of rear drive wheels, a rotatable cutting blade, and multiple battery packs removably coupled to the riding lawn mower and structured to provide power to the riding lawn mower, each battery pack graspable and removable by a user, wherein the multiple battery packs jointly provide power to the riding lawn mower.

Abstract: A riding lawn mower comprising, a pair of rear drive wheels, a pair of front wheels, a deck positioned between the pair of front wheels and the pair of rear drive wheels, a rotatable cutting blade, and multiple battery packs removably coupled to the riding lawn mower and structured to provide power to the riding lawn mower, each battery pack graspable and removable by a user, wherein the multiple battery packs jointly provide power to the riding lawn mower.

Abstract: Some embodiments of the invention provide a novel architecture for debugging devices. This architecture includes numerous devices that without user intervention automatically detect and report bug events to a set of servers that aggregate and process the bug events. When a device detects a potential bug event, the device in some embodiments generates a description of the potential bug event, and sends the generated description to the server set through a network. In addition to generating such a description, the device in some embodiments directs one or more of its modules to gather and store a collection of one or more data sets that are relevant to the potential bug event, in case the event has to be further analyzed by the server set. In the discussion below, the generated bug-event description is referred to as the event signature, while the gathered collection of data sets for an event is referred to as the event's data archive.

Abstract: Some embodiments of the invention provide a novel architecture for debugging devices. This architecture includes numerous devices that without user intervention automatically detect and report bug events to a set of servers that aggregate and process the bug events. When a device detects a potential bug event, the device in some embodiments generates a description of the potential bug event, and sends the generated description to the server set through a network. In addition to generating such a description, the device in some embodiments directs one or more of its modules to gather and store a collection of one or more data sets that are relevant to the potential bug event, in case the event has to be further analyzed by the server set. In the discussion below, the generated bug-event description is referred to as the event signature, while the gathered collection of data sets for an event is referred to as the event's data archive.

Abstract: A scalable power unit for powering one or more electric motors of a riding vehicle and/or a piece of outdoor power equipment. The scalable power unit includes a number of interconnected battery packs. The battery packs can be received in a battery tray or stacked to form the scalable power unit. Each battery pack can be removed and used separately or added to a combination of battery packs. A control unit selectively opens and closes switching elements to separately control the connections between the battery packs and an electrical load, such as a motor. During charging, the control unit opens and closes the switching elements to control the charging rate of the individual battery packs. When the battery packs are connected to an electric load, the control unit controls the state of the switching elements to selectively discharge the battery packs to power the riding vehicle and/or electric loads.

Abstract: Some embodiments of the invention provide a novel architecture for debugging devices. This architecture includes numerous devices that without user intervention automatically detect and report bug events to a set of servers that aggregate and process the bug events. When a device detects a potential bug event, the device in some embodiments generates a description of the potential bug event, and sends the generated description to the server set through a network. In addition to generating such a description, the device in some embodiments directs one or more of its modules to gather and store a collection of one or more data sets that are relevant to the potential bug event, in case the event has to be further analyzed by the server set. In the discussion below, the generated bug-event description is referred to as the event signature, while the gathered collection of data sets for an event is referred to as the event's data archive.

Abstract: Some embodiments of the invention provide a novel architecture for debugging devices. This architecture includes numerous devices that without user intervention automatically detect and report bug events to a set of servers that aggregate and process the bug events. When a device detects a potential bug event, the device in some embodiments generates a description of the potential bug event, and sends the generated description to the server set through a network. In addition to generating such a description, the device in some embodiments directs one or more of its modules to gather and store a collection of one or more data sets that are relevant to the potential bug event, in case the event has to be further analyzed by the server set. In the discussion below, the generated bug-event description is referred to as the event signature, while the gathered collection of data sets for an event is referred to as the event's data archive.

Abstract: The present invention relates to a topical composition and method of use, specifically an oil-in-water emulsion, comprised of sweet almond oil, lavender oil, rose oil, cinnamon bark oil, and coriander seed oil in a physiologically acceptable topical carrier. The composition is applied to a circumcised penis to enhance sensitivity, preferably twice daily for a time period of at least about two weeks. Thereafter a maintenance dose can be applied once a day to maintain a desired level of sensitivity.

Abstract: The present invention relates to a topical composition and method of use, specifically an oil-in-water emulsion, comprised of sweet almond oil, lavender oil, rose oil, cinnamon bark oil, and coriander seed oil in a physiologically acceptable topical carrier. The composition is applied to a circumcised human penis to enhance sensitivity, preferably twice daily for a time period of at least about two weeks. Thereafter a maintenance dose can be applied once a day to maintain a desired level of sensitivity.

Abstract: The present invention relates to a topical composition and method of use, specifically an oil-in-water emulsion, comprised of sweet almond oil, lavender oil, rose oil, cinnamon bark oil, and coriander seed oil in a physiologically acceptable topical carrier. The composition is applied to a circumcised human penis to enhance sensitivity, preferably twice daily for a time period of at least about two weeks. Thereafter a maintenance dose can be applied once a day to maintain a desired level of sensitivity.

Abstract: A battery enclosure is provided that externally shorts the enclosed battery, or batteries, immediately prior to the battery being punctured. As a result, the battery's state-of-charge is decreased, leading to a less severe reaction when the battery case is punctured.