Abstract: Methods for causing mutations in genes expressed in eukaryotic cells are provided. The methods involve expressing an activation-induced cytidine deaminase (AID) in the cells. The mutated genes can be any gene that is operably linked to a promoter, where the gene is within about 2 kilobases of the promoter. Examples include antibody genes. Also provided are cells expressing AID. The cells can be from any eukaryote, and include hybridoma cells and myeloma fusion partners.

Abstract: Spherical aberration correction is provided for CD writing in a double (CD+DVD), triple (CD+DVD+BD) or quadruple (CD+DVD+BD+HD-DVD) writer, which use the same light path for CD and DVD. In an optical drive that uses numerous laser wavelengths combined into one light path each wavelength having a different numerical apertures a correction for spherical aberration is made to correct for effective numerical apertures of the light path that becomes shifted up from the original value to higher values. The correction in spherical aberration removes that effect of the higher effective NA and defects, particularly in writing, are corrected.

Abstract: System and method for enabling proximity-triggered messaging in certain coverage areas for social networks and communities-based services, the system comprising: at least one local unit with cellular radio transceiver means, located within a corresponding coverage area and configured for: broadcasting a LAC different from any other LAC of the radio cells in the surroundings; establishing a Location Update dialogue with any mobile phone answering to the LAC broadcast, obtaining its IMSI number; sending a Location Updating Reject message to each mobile phone whose IMSI number has been obtained; sending said IMSI number to a central unit; the central unit configured to: obtain, for each IMSI number, one valid identity in a community-based service; provide at least one social network server associated to the corresponding valid on-line identity with the valid identity.

Abstract: The invention relates to an optical disk drive. The optical disk drive has an objective lens to be driven by a focus actuator with a focus offset for focusing an incident beam onto an optical disk into a spot with a spherical aberration, and a processor to derive a first and a second characteristic from a sensor output signal and obtain a spherical aberration correction value (SA) from a pre-determined function, the pre-determined function defining a spherical aberration correction value in dependence on a focus offset difference value (?FO). The focus offset difference value (?FO) is determined from a difference between a second optimal focus offset at which the second characteristic is optimal and a first optimal focus offset at which the first characteristic is optimal. The spherical aberration correction value (SA) can be used to achieve a correction to the spherical aberration of the spot.

Abstract: System and method for local marketing at the point of sale, the system comprising: at least one local unit (1,1?,1?) with cellular radio transceiver means, located at a local marketing area within a coverage area (4,4?,4?), configured for: broadcasting a LAC different from any other LAC of the radio cells in the surroundings; establishing a Location Update dialogue with any mobile phone (3,3?,3?) answering to the LAC broadcast, obtaining its IMSI number; sending a Location Updating Reject message to each mobile phone (3,3?,3?) whose IMSI number has been obtained; sending said IMSI number to a central unit (2); the central unit (2), configured to: obtain, for each IMSI number, a user identity useful to advertisers; receive requests from at least one advertiser (9,9?,9?) for capturing user identities in local marketing areas; determine the advertisers (9,9?,9?) interested in the user identities received, and provide (20) them to the corresponding advertiser (9,9?,9?).

Abstract: A system for monitoring road usage by vehicles having associated vehicle terminal units operable to communicate with a cellular telecommunications network, the system comprising: an identity capture unit configured to broadcast, in the licensed spectrum of at least one cellular telecommunications network operator, a Location Area Code (LAC) different from any other LAC of the radio cells of the cellular telecommunications network in the surroundings; said identity capture unit establishing a Location Update dialog with each associated vehicle terminal unit answering to the LAC broadcast; and obtaining from each answering vehicle terminal unit at least one unique identifier; and a subscriber validation unit, which in operation checks the captured identifiers against those of subscribers of the road usage charging service and, in case of match, reports the identifier capture event. That event may be used as a trigger for the systems of the road usage charging service.

Abstract: Spherical aberration correction is provided for CD writing in a double (CD+DVD), triple (CD+DVD+BD) or quadruple (CD+DVD+BD+HD-DVD) writer, which use the same light path for CD and DVD. In an optical drive that uses numerous laser wavelengths combined into one light path each wavelength having a different numerical apertures a correction for spherical aberration is made to correct for effective numerical apertures of the light path that becomes shifted up from the original value to higher values. The correction in spherical aberration removes that effect of the higher effective NA and defects, particularly in writing, are corrected.

Abstract: The invention relates to an optical disk drive. The optical disk drive has an objective lens to be driven by a focus actuator with a focus offset for focusing an incident beam onto an optical disk into a spot with a spherical aberration, and a processor to derive a first and a second characteristic from a sensor output signal and obtain a spherical aberration correction value (SA) from a pre-determined function, the pre-determined function defining a spherical aberration correction value in dependence on a focus offset difference value (?FO). The focus offset difference value (?FO) is determined from a difference between a second optimal focus offset at which the second characteristic is optimal and a first optimal focus offset at which the first characteristic is optimal. The spherical aberration correction value (SA) can be used to achieve a correction to the spherical aberration of the spot.

Abstract: A procedure for determination of flow and fraction of fluids includes the steps of: determination of Spin-Lattice relaxation times to be measured; assignment of radiofrequency pulse sequences corresponding to each of the fluids to be measured and with the fluid flow; application of a radiofrequency pulse sequence to a first coil; application of a second radiofrequency pulse sequence to the first coil; and application of a third radiofrequency pulse sequence to a second coil.

Abstract: A welding machine having a welding unit for generating a welding voltage/current, and at least one welding tool connectable to the welding unit by a cable and supplied by the cable with welding voltage/current; the welding unit has a closed protective casing, and a cooling unit for cooling the welding tool and/or cable on command; and the welding machine also has a modular unit containing the cooling unit and insertable stably and in easily removable manner inside the casing which is closed for protection of the welding unit, so as to be easily extracted and detached from the casing.

Abstract: An electric arc welding machine having a welding tool designed for manual manipulation by the user, and an electric power unit connected electrically to the welding tool by a connecting cable to supply the welding tool with electric operating power; the electric power unit having an electric power converter for powering the welding tool over the connecting cable, an electronic central control unit for controlling the electric power converter, and a control panel allowing the user to manually set, in the electronic central control unit, the desired operating mode from those available; the welding machine also having manually-operated first selecting elements by which to manually set in the electronic central control unit the operating specifications of the connecting cable and/or the welding tool currently connected to the electric power unit.

Abstract: Methods for causing mutations in genes expressed in eukaryotic cells are provided. The methods involve expressing an activation-induced cytidine deaminase (AID) in the cells. The mutated genes can be any gene that is operably linked to a promoter, where the gene is within about 2 kilobases of the promoter. Examples include antibody genes. Also provided are cells expressing AID. The cells can be from any eukaryote, and include hybridoma cells and myeloma fusion partners.

Abstract: A procedure for determination of flow and fraction of fluids includes the steps of: determination of Spin-Lattice relaxation times to be measured; assignment of radiofrequency pulse sequences corresponding to each of the fluids to be measured and with the fluid flow; application of a radiofrequency pulse sequence to a first coil; application of a second radiofrequency pulse sequence to the first coil; and application of a third radiofrequency pulse sequence to a second coil.

Abstract: A heat exchanger module for a motor vehicle having a fan shroud mounted on a heat exchanger. The shroud includes two blocks that extend from a first side of a duct and are adapted to engage corresponding housings in a first manifold of the heat exchanger. Two spring clips extend from a second side of the fan duct and have an aperture for accommodating a lug projecting from a side face of a second manifold of the heat exchanger.

Abstract: A device for tiltable ejectors of fruit in conveyor carts integrated into electronic classifiers has a lifting-ejector formed by a bent and supported vertical shaft which turns freely by its upper end section and is operationally connected to the tiltable ejector. Its lower end section is parallel to the supported upper part and serves to pass along an axis of advance, first in relation to a fixed rectilinear deflector, followed within an angularly displaceable deflector under electronic control and finally above an actuating ramp. The angularly displaceable deflector has a position of rest in which, together with the fixed deflector, it determines the trajectory of non-actuation of the lifting-ejector. Another position directs it toward a ramp and determines its trajectory of actuation to secure tilting of the ejector and the fruit carried thereby.