Abstract: An innovative stable immediate release drug for the treatment, control, and better management of type 2 diabetes mellitus containing a sulfonylurea such as glimepiride, a dipeptidyl peptidase-4 (DPP4) inhibitor such as vildagliptin, and a biguanidine such as metformin. At the same time, this invention allows solving a set of important technological challenges in the manufacture of said drug product due to the physicochemical properties and the difference in dosage of the synergistic combination of the drugs.

Abstract: The present disclosure relates to a heating, ventilation, and air conditioning (HVAC) system that includes a heat exchanger configured to circulate a working fluid therethrough, a valve configured to regulate a flow rate of the working fluid through the heat exchanger, and a valve controller configured to modify a valve position control signal received from an external controller, separate from the valve controller, based on a temperature differential of the working fluid entering and exiting the heat exchanger.

Abstract: The recited invention is a method of treating patients having macular edema secondary to branch renal vein occlusion. The patients are treated with a liposomal nanoparticle formulation comprising thermodynamically stable liposomes and a steroid such as triamcinolone acetonide. The formulation is a topical ophthalmic formulation administered topically to treat the posterior segment disease.

Abstract: The present invention is related to biotechnology, particularly to the field of human health. It provides new vaccine compositions that comprise as active principle a system that contains the recombinant human EGF, or peptides thereof, and a carrier protein or peptide, bound to a nucleus constituted by inorganic nanoparticles, with nanometric or submicrometric scale dimensions. These vaccine compositions are useful for the chronic treatment of cancer and have as advantages that their administration does not result in the appearance of adverse effects at the injection site and that they do not accumulate in the body.

Abstract: A wind turbine is disclosed which comprises a control system configured to execute at least one ice removal routine which comprises a heating stage of at least one of the blades (3), and a mechanical removal ice stage. A wind turbine removing ice method is also disclosed which comprises a stage wherein the presence of ice is detected on at least one of the blades and, once said presence of ice is detected, comprises a stage wherein at least one ice removal routine is activated which comprises, in turn, a heating stage of at least one of the blades and a mechanical removing ice stage on at least said blade.

Abstract: An actuator includes a motor, a drive member coupled to the motor and structured to transfer movement from the motor to an external mechanism, and a control chip configured to host a web server, connect with a wireless communication network and provide access to the web server via the wireless communication network, and control the motor using reprogrammable control logic. The reprogrammable control logic is adjustable by a user via the web server and the wireless communication network.

Abstract: A prosthetic device can be implanted in the corpora cavernosa of a penis with erectile dysfunction. The device being formed by two cylinders that can be inflated with a fluid. The device comprises a variable-length erectable portion formed by a chamber that can be pressurized with a low volume of fluid and is formed between an expandable membrane and an axially extendable and foldable longitudinal rib. The membrane and rib extend between a distal tip element and an intermediate connector from which a shortenable anchoring rod emerges, the rib being a single piece formed by a variable-length distal section, an intermediate section that is foldable and extendable in an axial direction, and a proximal section comprising optimized means for the continuous lateral supply of the fluid to the pressurisable chamber. The device also has an integrated unit for storing and pressurizing the fluid, which can be implanted in the scrotum.

Abstract: A wind turbine control method involves calculating a value indicative of a misalignment ? of the wind turbine on a basis of at least one signal indicative of wind direction. A determination is made as to whether the value indicative of the misalignment ? of the wind turbine is above a first predefined misalignment threshold value. A value of a blade pitch angle ? is adapted. At least one of the blades of the wind turbine is rotated about its longitudinal axis on the basis of the adapted value of the blade pitch angle ?.

Abstract: The present invention is related, but is not restricted, to the field of the study or analysis of materials by determining the chemical or physical properties thereof, in particular the field of the investigation or analysis of materials by using electromagnetic waves, specifically providing a method from measuring internal stress in tires, using a ferromagnetic material. The invention provides a method for measuring internal stress in a tire, characterized in that it comprises: incorporating into the tire a material that is a combination of a rubber matrix and a plurality of microwires made of a ferromagnetic material; irradiating said tire with electromagnetic waves by means of a transmitting antenna; receiving an electromagnetic wave absorption response from said tire by means of a receiving antenna; and determining the internal stress of the tire by means of a processor operatively connected to said receiving antenna, on the basis of the electromagnetic wave absorption response.

Abstract: A control system and control method of a wind farm which allows taking into account dynamic variations in the possibilities of reactive power generation of each wind turbine with respect to maximum reactive power generation capacities. The system calculates an initial torque and a maximum reactive power limit such that it is not necessary to apply limitations to the initial torque.

Abstract: The invention relates to a recombinant Marasmius rotula unspecific peroxygenase (rMroURO) and two mutants thereof, wherein said mutants show enhanced selectivity towards either the epoxidation or the (sub)terminal ?/(?-1)-hydroxylation of unsaturated fatty acids. The invention also refers to the use of these enzyme variants for the specific epoxidation or hydroxylation of fatty acids such as oleic acid, linoleic acid and/or alpha-linolenic acid.

Abstract: The present disclosure relates to electronic circuit design, and more specifically, to determining the computational requirements of fully synthesizing a printed circuit board and/or package. Embodiments may include receiving, using a processor, one or more PCB electronic design files and determining whether the PCB electronic design files include data required for a synthesis engine. If any data is missing, the method may include inferring one or more parameters using an inference engine and providing the one or more parameters to the synthesis engine, wherein the synthesis engine includes at least one of a placement, via assignment, routing, and metal pouring processes. The method may also include collecting process data from the placement, via assignment, routing, and metal pouring processes and training a machine learning system using the process data.

Abstract: A control system and control method of a wind farm allows taking into account dynamic variations in the possibilities of reactive power generation of each wind turbine with respect to maximum reactive power generation capacities. The system is configured to receive from at least one first wind turbine of the wind turbines of the wind farm a maximum reactive power limit desired lower than a minimum reactive power capacity required. The system is configured to calculate the individual reactive power setpoints for each of the at least two wind turbines of the wind farm such that the individual reactive power setpoint for the at least one first wind turbine of the wind farm does not exceed the maximum reactive power limit desired.

Abstract: Disclosed herein are embodiments of an aging heat treatment that can be used to replace conventional aging steps when making alloy embodiments of the present disclosure. Embodiments of the disclosed aging heat treatment reduce cost and complexity in producing aluminum alloy-based components while also promoting and/or improving microstructure stability of the aluminum alloys.

Abstract: Nebulizer systems, adapters, methods, and apparatuses are described for a nebulizer adapter that includes a body, an inlet for aerosolized respiratory medications and/or medical marijuana and/or other pharmaceuticals, a breathing gas inlet tube and outlet tube, a barrier or body, and a drain lumen port that passes from the bottom of the barrier or body of the apparatus to the exterior into a port drain. The port drain would be in fluid communication with a receptacle removably attached to the annular lid that is attached to the bottom of the adapter body for collecting condensed moisture, wherein the receptacle comprise an actuator member configured to actuate the airtight seal of the annular lid upon attachment. The adapter includes a sensory system and temperature regulating system that continuously detects and regulates the temperature within an adapter to minimize condensates from forming and interfering with patient care.

Abstract: The invention relates to a nutraceutical formulation of blueberry extract, fish oil (omega-3 and omega-6), recombinant human lactoferrin, vitamin A and vitamin E, for human oral consumption. The invention belongs to the field of ophthalmology and has been developed as a coadjuvant for preserving the health of the precorneal film and of the eye surface. This formulation contains an extract of natural origin (Vaccinium myrtillus L) with antioxidant and anti-inflammatory properties; it also uses eicosapentaenoic acid (EPA), omega-6, and docosahexaenoic acid (DHA), omega-3, obtained from fish oil and which, together with lactoferrin, vitamin A and vitamin E, improves tear quality, since these compounds have anti-microbial and anti-inflammatory effects. This formulation has been designed as a coadjuvant for preserving the health of the precorneal film.

Abstract: The present disclosure relates to a heating, ventilation, and air conditioning (HVAC) system that includes a heat exchanger configured to circulate a working fluid therethrough, a valve configured to regulate a flow rate of the working fluid through the heat exchanger, and a valve controller configured to modify a valve position control signal received from an external controller, separate from the valve controller, based on a temperature differential of the working fluid entering and exiting the heat exchanger.

Abstract: The present invention relates with the technical field of biotechnology, and particularly provides a promoter inducible under abiotic stress conditions, which is used to regulate expression of a nucleotide sequence encoding a product of interest under these conditions. The invention also refers to a genetic construction containing said promoter, the plant cells transformed with said construction as well as the transgenic plants that can be regenerated from said cells, and which are capable of growing and developing properly, keeping high levels of productive yield under abiotic stress conditions.

Abstract: A wind turbine is disclosed which comprises a control system configured to execute at least one ice removal routine which comprises a heating stage of at least one of the blades (3), and a mechanical removal ice stage. A wind turbine removing ice method is also disclosed which comprises a stage wherein the presence of ice is detected on at least one of the blades and, once said presence of ice is detected, comprises a stage wherein at least one ice removal routine is activated which comprises, in turn, a heating stage of at least one of the blades and a mechanical removing ice stage on at least said blade.

Abstract: Method of reducing loads acting on a wind turbine yaw system in a wind turbine comprising a nacelle (2), a rotor which comprises at least one rotor blade (3) with a pitch control system and further comprising a yaw system that comprises the steps of detecting a yaw misalignment (?), enabling a yaw maneuver and performing a pitch control in order to reduce a yaw moment (Mz) acting on the wind turbine once the yaw misalignment (?) is detected and prior to enabling the yaw maneuver. Thus, when a yaw movement to reduce the yaw misalignment is commanded, the yaw moment (Mz) due to aerodynamic forces has been reduced by means of the pitch control and undesired yaw movements are prevented.