Patents by Inventor Aleksa Jovanovic

Aleksa Jovanovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
    Patent number: 11957698
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.
    Type: Grant
    Filed: July 8, 2022
    Date of Patent: April 16, 2024
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Aleksa Jovanovic, Lei Shi, Eric Roche, Paul Renick
  • USE OF THERMOLYSIN TO REDUCE OR ELIMINATE BACTERIAL BIOFILMS FROM SURFACES
    Publication number: 20230346898
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising thermolysin.
    Type: Application
    Filed: March 13, 2023
    Publication date: November 2, 2023
    Inventors: Lei SHI, Catherine VAN DER KAR, Aleksa JOVANOVIC, Eric ROCHE
  • SYNERGISTIC ANTIBACTERIAL ACTIVITY OF MEDIUM POLARITY OILS IN COMBINATION WITH ANTIBACTERIAL AGENTS ON BACTERIAL BIOFILMS
    Publication number: 20230345938
    Abstract: The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.
    Type: Application
    Filed: April 3, 2023
    Publication date: November 2, 2023
    Inventors: Aleksa JOVANOVIC, Lei SHI, Eric ROCHE, Paul RENICK
  • SYNERGISTIC COMBINATION OF THERMOLYSIN AND AN ANTIBACTERIAL AGENT TO REDUCE OR ELIMINATE BACTERIAL BIOFILMS FROM SURFACES
    Publication number: 20230201229
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.
    Type: Application
    Filed: July 8, 2022
    Publication date: June 29, 2023
    Inventors: Aleksa JOVANOVIC, Lei SHI, Eric ROCHE, Paul RENICK
  • Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms
    Patent number: 11641856
    Abstract: The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: May 9, 2023
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Aleksa Jovanovic, Lei Shi, Eric Roche, Paul Renick
  • Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
    Patent number: 11628207
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising thermolysin.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: April 18, 2023
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Catherine Van Der Kar, Aleksa Jovanovic, Eric Roche
  • DISSOLVABLE GEL-FORMING FILM FOR DELIVERY OF ACTIVE AGENTS
    Publication number: 20230055292
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Application
    Filed: August 22, 2022
    Publication date: February 23, 2023
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • STABLE THERMOLYSIN HYDROGEL
    Publication number: 20230031268
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Application
    Filed: August 15, 2022
    Publication date: February 2, 2023
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Dissolvable gel-forming film for delivery of active agents
    Patent number: 11452698
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: September 27, 2022
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Stable thermolysin hydrogel
    Patent number: 11446364
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: September 20, 2022
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
    Patent number: 11413300
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: August 16, 2022
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Aleksa Jovanovic, Lei Shi, Eric Roche, Paul Renick
  • SYNERGISTIC ANTIBACTERIAL ACTIVITY OF MEDIUM POLARITY OILS IN COMBINATION WITH ANTIBACTERIAL AGENTS ON BACTERIAL BIOFILMS
    Publication number: 20220192191
    Abstract: The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.
    Type: Application
    Filed: December 8, 2021
    Publication date: June 23, 2022
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Aleksa JOVANOVIC, Lei SHI, Eric ROCHE, Paul RENICK
  • Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms
    Patent number: 11197476
    Abstract: The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: December 14, 2021
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Aleksa Jovanovic, Lei Shi, Eric Roche, Paul Renick
  • Use of seaprose to remove bacterial biofilm
    Patent number: 11096992
    Abstract: A method of disrupting a bacterial biofilm present on a surface, comprising applying a composition that includes a semi-alkaline protease produced by the fermentation of the fungus Aspergillus melleus (Seaprose) to the bacterial biofilm, wherein application of the composition to the bacterial biofilm disrupts the matrix of the bacterial biofilm.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: August 24, 2021
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Aleksa Jovanovic, Catherine Van Der Kar, Eric Roche
  • ENZYMATIC WOUND DEBRIDING COMPOSITIONS WITH ENHANCED ENZYMATIC ACTIVITY
    Publication number: 20200129656
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 30, 2020
    Inventors: LEI SHI, ALEKSA JOVANOVIC, DUNCAN AUST
  • SYNERGISTIC ANTIBACTERIAL ACTIVITY OF MEDIUM POLARITY OILS IN COMBINATION WITH ANTIBACTERIAL AGENTS ON BACTERIAL BIOFILMS
    Publication number: 20200085044
    Abstract: The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.
    Type: Application
    Filed: August 1, 2019
    Publication date: March 19, 2020
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Aleksa JOVANOVIC, Lei SHI, Eric ROCHE, Paul RENICK
  • Enzymatic wound debriding compositions with enhanced enzymatic activity
    Patent number: 10556037
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: February 11, 2020
    Assignee: Smith & Nephew, Inc.
    Inventors: Lei Shi, Aleksa Jovanovic, Duncan Aust
  • SYNERGISTIC COMBINATION OF THERMOLYSIN AND AN ANTIBACTERIAL AGENT TO REDUCE OR ELIMINATE BACTERIAL BIOFILMS FROM SURFACES
    Publication number: 20190365791
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.
    Type: Application
    Filed: January 26, 2018
    Publication date: December 5, 2019
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Aleksa JOVANOVIC, Lei SHI, Eric ROCHE, Paul RENICK
  • USE OF THERMOLYSIN TO REDUCE OR ELIMINATE BACTERIAL BIOFILMS FROM SURFACES
    Publication number: 20190262437
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising thermolysin.
    Type: Application
    Filed: July 26, 2017
    Publication date: August 29, 2019
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Lei SHI, Catherine VAN DER KAR, Aleksa JOVANOVIC, Eric ROCHE
  • ENZYMATIC WOUND DEBRIDING COMPOSITIONS WITH ENHANCED ENZYMATIC ACTIVITY
    Publication number: 20190060509
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Application
    Filed: October 25, 2018
    Publication date: February 28, 2019
    Inventors: Lei SHI, Aleksa JOVANOVIC, Duncan AUST