Patents by Inventor Aleksa Jovanovic

Aleksa Jovanovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Wound debridement compositions containing seaprose and methods of wound treatment using same
    Patent number: 10206982
    Abstract: Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: February 19, 2019
    Assignee: SMITH & NEPHEW ORTHOPAEDICS AG
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Enzymatic wound debriding compositions with enhanced enzymatic activity
    Patent number: 10155061
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: December 18, 2018
    Assignee: Smith & Nephew, Inc.
    Inventors: Lei Shi, Aleksa Jovanovic, Duncan Aust
  • SYNERGISTIC ANTIBACTERIAL ACTIVITY OF MEDIUM POLARITY OILS IN COMBINATION WITH ANTIBACTERIAL AGENTS ON BACTERIAL BIOFILMS
    Publication number: 20180289003
    Abstract: The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.
    Type: Application
    Filed: August 23, 2016
    Publication date: October 11, 2018
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Aleksa JOVANOVIC, Lei SHI, Eric ROCHE, Paul RENICK
  • Enzymatic wound debriding compositions with enhanced enzymatic activity
    Patent number: 9694100
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: July 4, 2017
    Assignee: Smith & Nephew, Inc.
    Inventors: Lei Shi, Aleksa Jovanovic, Duncan Aust
  • WOUND DEBRIDEMENT COMPOSITIONS CONTAINING SEAPROSE AND METHODS OF WOUND TREATMENT USING SAME
    Publication number: 20170136103
    Abstract: Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.
    Type: Application
    Filed: January 27, 2017
    Publication date: May 18, 2017
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • ENZYMATIC WOUND DEBRIDING COMPOSITIONS WITH ENHANCED ENZYMATIC ACTIVITY
    Publication number: 20170072029
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 16, 2017
    Inventors: Lei SHI, Aleksa JOVANOVIC, Duncan AUST
  • DISSOLVABLE GEL-FORMING FILM FOR DELIVERY OF ACTIVE AGENTS
    Publication number: 20160008293
    Abstract: Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 14, 2016
    Inventors: Lei SHI, Aleksa JOVANOVIC, Dennis CARSON
  • STABLE THERMOLYSIN HYDROGEL
    Publication number: 20150283217
    Abstract: Disclosed is a hydrogel comprising a hydrophilic gelling agent that includes a nonionic cellulose ether, and active thermolysin, wherein the proteolytic activity of the thermolysin does not decrease by more than 20% when stored at room temperature for 6 months.
    Type: Application
    Filed: November 14, 2013
    Publication date: October 8, 2015
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • USE OF SEAPROSE TO REMOVE BACTERIAL BIOFILM
    Publication number: 20150118219
    Abstract: Disclosed are compositions and methods for their use in disrupting a bacterial biofilm present on a surface, comprising applying a composition that includes Seaprose to the bacterial biofilm, wherein application of the composition to the bacterial biofilm disrupts the matrix of the bacterial biofilm.
    Type: Application
    Filed: May 10, 2013
    Publication date: April 30, 2015
    Inventors: Lei Shi, Aleksa Jovanovic, Catherine Van Der Kar, Eric Roche
  • WOUND DEBRIDEMENT COMPOSITIONS CONTAINING SEAPROSE AND METHODS OF WOUND TREATMENT USING SAME
    Publication number: 20140154235
    Abstract: Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.
    Type: Application
    Filed: May 11, 2012
    Publication date: June 5, 2014
    Applicant: SMITH & NEPHEW ORTHOPAEDICS AG
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • ENZYMATIC WOUND DEBRIDING COMPOSITIONS WITH ENHANCED ENZYMATIC ACTIVITY
    Publication number: 20130045196
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Application
    Filed: December 8, 2010
    Publication date: February 21, 2013
    Applicant: HEALTHPOINT, LTD.
    Inventors: Lei Shi, Aleksa Jovanovic, Duncan Aust