Patents by Inventor Aleksandre T Sambelashvili

Aleksandre T Sambelashvili has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200397962
    Abstract: The disclosure describes systems and techniques for detection of pump thrombosis in mechanical circulatory support (MCS) devices. An example pump thrombosis detection system includes a transducer and processing circuitry. The transducer may be configured to generate a signal representative of a mechanical wave from a mechanical circulatory support device. The processing circuitry is communicatively coupled to the transducer. The processing circuitry may be configured to determine an indication of pump thrombosis based on the signal and, based on the indication of pump thrombosis, control the pump thrombosis detection system to at least one of generate an alert or initiate an intervention.
    Type: Application
    Filed: August 31, 2020
    Publication date: December 24, 2020
    Inventors: Aleksandre T. Sambelashvili, David A. Anderson, James K. Carney, David M. Steinhaus, Narendra K. Simha
  • Patent number: 10765790
    Abstract: An example pump thrombosis detection system includes a transducer and processing circuitry. The transducer may be configured to generate a signal representative of a mechanical wave from a mechanical circulatory support device. The processing circuitry is communicatively coupled to the transducer. The processing circuitry may be configured to determine an indication of pump thrombosis based on the signal and, based on the indication of pump thrombosis, control the pump thrombosis detection system to at least one of generate an alert or initiate an intervention.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: September 8, 2020
    Assignee: Medtronic, Inc.
    Inventors: Aleksandre T. Sambelashvili, David A. Anderson, James K. Carney, David M. Steinhaus, Narendra K. Simha
  • Patent number: 10449368
    Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: October 22, 2019
    Assignee: Medtronic, Inc.
    Inventors: Aleksandre T. Sambelashvili, Thomas J. Mullen, Todd J. Sheldon
  • Publication number: 20190255235
    Abstract: The disclosure describes systems and techniques for detection of pump thrombosis in mechanical circulatory support (MCS) devices. An example pump thrombosis detection system includes a transducer and processing circuitry. The transducer may be configured to generate a signal representative of a mechanical wave from a mechanical circulatory support device. The processing circuitry is communicatively coupled to the transducer. The processing circuitry may be configured to determine an indication of pump thrombosis based on the signal and, based on the indication of pump thrombosis, control the pump thrombosis detection system to at least one of generate an alert or initiate an intervention.
    Type: Application
    Filed: May 2, 2018
    Publication date: August 22, 2019
    Inventors: Aleksandre T. Sambelashvili, David A. Anderson, James K. Carney, David M. Steinhaus, Narendra K. Simha
  • Patent number: 10086206
    Abstract: Techniques and systems for monitoring cardiac arrhythmias and delivering electrical stimulation therapy using a subcutaneous device (e.g. subcutaneous implantable (SD)) and a leadless pacing device (LPD) are described. In one or more embodiments, a computer-implemented method includes sensing a first electrical signal from a heart of a patient through a SD. The first signal is stored into memory and serves as a baseline rhythm for a patient. Subsequently, a second signal is sensed from the heart through the SD. A cardiac condition can be detected within the sensed second electrical signal through the SD. A determination is made as to whether cardiac resynchronization therapy (CRT) is appropriate to treat the detected cardiac condition. A determination can then be made as to the timing of pacing pulse delivery to cardiac tissue through a leadless pacing device (LPD).
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 2, 2018
    Assignee: Medtronic, Inc.
    Inventor: Aleksandre T. Sambelashvili
  • Publication number: 20170340885
    Abstract: Techniques and systems for monitoring cardiac arrhythmias and delivering electrical stimulation therapy using a subcutaneous device (e.g. subcutaneous implantable (SD)) and a leadless pacing device (LPD) are described. In one or more embodiments, a computer-implemented method includes sensing a first electrical signal from a heart of a patient through a SD. The first signal is stored into memory and serves as a baseline rhythm for a patient. Subsequently, a second signal is sensed from the heart through the SD. A cardiac condition can be detected within the sensed second electrical signal through the SD. A determination is made as to whether cardiac resynchronization therapy (CRT) is appropriate to treat the detected cardiac condition. A determination can then be made as to the timing of pacing pulse delivery to cardiac tissue through a leadless pacing device (LPD).
    Type: Application
    Filed: July 31, 2017
    Publication date: November 30, 2017
    Inventor: Aleksandre T. SAMBELASHVILI
  • Patent number: 9789319
    Abstract: Techniques and systems for monitoring cardiac arrhythmias and delivering electrical stimulation therapy using a subcutaneous device (e.g. subcutaneous implantable (SD)) and a leadless pacing device (LPD) are described. In one or more embodiments, a computer-implemented method includes sensing a first electrical signal from a heart of a patient through a SD. The first signal is stored into memory and serves as a baseline rhythm for a patient. Subsequently, a second signal is sensed from the heart through the SD. A cardiac condition can be detected within the sensed second electrical signal through the SD. A determination is made as to whether cardiac resynchronization therapy (CRT) is appropriate to treat the detected cardiac condition. A determination can then be made as to the timing of pacing pulse delivery to cardiac tissue through a leadless pacing device (LPD). The LPD receives communication from the SD requesting the LPD to deliver CRT to the heart.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: October 17, 2017
    Assignee: Medtronic, Inc.
    Inventor: Aleksandre T. Sambelashvili
  • Patent number: 9643013
    Abstract: Provided herewith are methods and apparatus for optimizing an atrioventricular (AV) pacing delay interval. One manner described involves dynamically programming an AV interval in cardiac resynchronization therapy (CRT) device having a rate-adaptive AV (RAAV) feature in such a way that not less than a minimum AV interval is maintained. That is, the AV interval is not allowed to be reduced so much that the P-wave is truncated by the QRS complex. In this form of the invention, the AV interval is reduced by one millisecond per one bpm increase in heart rate (and vice versa for reducing heart rate) but maintained at a value calculated from the end of the P-wave (PWend) and the beginning of the QRS complex (QRSbeg) or delivery of a ventricular pacing stimulus or to the end of the end of the QRS complex (QRSend).
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: May 9, 2017
    Assignee: Medtronic, Inc.
    Inventors: Aleksandre T Sambelashvili, Thomas J Mullen
  • Patent number: 9597512
    Abstract: Methods for optimizing an atrioventricular (AV) pacing delay interval based upon ECG-based optimization such that an AV pacing delay interval value can be dynamically adjusted in an ambulatory subject. Ends of P-waves are determined. An operating atrioventricular interval is modified to maintain intervals between the determined ends of P-waves and beginnings of corresponding following QRS complexes above a predetermined certain value. The value may be between 30 and 60 milliseconds.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: March 21, 2017
    Assignee: Medtronic, Inc.
    Inventors: Aleksandre T Sambelashvili, Thomas J Mullen
  • Patent number: 9566013
    Abstract: Novel methods and apparatus for dynamically monitoring paced and sensed P-wave duration, P-wave end and/or QRS duration and/or S-T segment duration, or length, in a patient having an implantable medical device (IMD) provides diagnostic and clinical benefit allowing for predictions about future arrhythmia, advanced notification, alert and intervention as well as providing acute and chronic information regarding cardiac status, including both possibly declining and/or improving cardiac function. The methods can be performed using a wide variety of IMDs, such as pacemakers, cardiac resynchronization therapy (CRT) device, implantable cardioverter defibrillators (ICDs), and implantable loop recorders (e.g., such as the REVEALĀ® device manufactured by Medtronic, Inc.).
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: February 14, 2017
    Assignee: Medtronic, Inc.
    Inventor: Aleksandre T Sambelashvili
  • Patent number: 9511233
    Abstract: Techniques and systems for monitoring cardiac arrhythmias and delivering electrical stimulation therapy using a subcutaneous device (e.g. subcutaneous implantable (SD)) is described. In one or more other embodiments, SD is implanted into a patient's heart. Electrical signals are then sensed which includes moderately lengthened QRS duration data from the patient's heart. A determination is made as to whether cardiac resynchronization pacing therapy (CRT pacing) is appropriate based upon the moderately lengthened QRS duration in the sensed electrical signals. The CRT pacing pulses are delivered to the heart using electrodes. In one or more embodiments, the SD can switch between fusion pacing and biventricular pacing based upon data (e.g. moderately lengthened QRS, etc.) sensed from the heart.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: December 6, 2016
    Assignee: Medtronic, Inc.
    Inventor: Aleksandre T. Sambelashvili
  • Publication number: 20160339255
    Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
    Type: Application
    Filed: August 1, 2016
    Publication date: November 24, 2016
    Inventors: Aleksandre T. Sambelashvili, Thomas J. Mullen, Todd J. Sheldon
  • Publication number: 20160339248
    Abstract: An implantable device and associated method for delivering multi-site pacing therapy is disclosed. The device comprises a set of electrodes including a first ventricular electrode and a second ventricular electrode, spatially separated from one another and all coupled to an implantable pulse generator. The device comprises a processor configured for selecting a first cathode and a first anode from the set of electrodes to form a first pacing vector at a first pacing site along a heart chamber and selecting a second cathode and a second anode from the set of electrodes to form a second pacing vector at a second pacing site along the same heart chamber. The pulse generator is configured to deliver first pacing pulses to the first pacing vector and delivering second pacing pulses to the second pacing vector. The pulse generator generates a recharging current for recharging a first coupling capacitor over a first recharge time period in response to the first pacing pulses.
    Type: Application
    Filed: April 21, 2016
    Publication date: November 24, 2016
    Inventors: Anthony W. Schrock, Jean E. Hudson, Karen J. Kleckner, John D. Wahlstrand, Michael W. Heinks, Michael L. Hudziak, Subham Ghosh, Aleksandre T. Sambelashvili
  • Patent number: 9403019
    Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: August 2, 2016
    Assignee: Medtronic, Inc.
    Inventors: Aleksandre T Sambelashvili, Thomas J Mullen, Todd J Sheldon
  • Patent number: 9399140
    Abstract: A leadless pacing device (LPD) includes a motion sensor configured to generate a motion signal as a function of heart movement. The LPD is configured to analyze the motion signal within an atrial contraction detection window that begins an atrial contraction detection delay period after activation of the ventricle, and detect a contraction of an atrium of the heart based on the analysis of the motion signal within the atrial contraction detection window. If the LPD does not detect a ventricular depolarization subsequent to the atrial contraction, e.g., with an atrio-ventricular (AV) interval beginning when the atrial contraction was detected, the LPD delivers a ventricular pacing pulse.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: July 26, 2016
    Assignee: Medtronic, Inc.
    Inventors: Yong K. Cho, Aleksandre T. Sambelashvili, Todd J. Sheldon
  • Patent number: 9289612
    Abstract: An implantable medical system is configured to coordinate ventricular pacing with intrinsic depolarizations of another chamber. The implantable medical system includes a leadless pacing device implanted on or within the ventricle. Another implantable medical device is configured to sense an intrinsic depolarization the other chamber of the heart of the patient, and in response to the intrinsic depolarization of the other chamber, deliver an electrical pulse. The leadless pacing device is configured to detect the electrical pulse delivered by the other implantable medical device and, in response to detecting the electrical pulse delivered by the other implantable medical device, deliver a pacing pulse to the ventricle via at least a first electrode in coordination with the intrinsic depolarization of the other chamber.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: March 22, 2016
    Assignee: Medtronic Inc.
    Inventors: Aleksandre T Sambelashvili, Yong K Cho, Todd J Sheldon
  • Patent number: 9272147
    Abstract: A medical device system and method for delivering mechanically fused left ventricular cardiac stimulation. A sensor monitors left ventricular acceleration while left ventricular cardiac stimulation is provided at an AV interval. The left ventricular acceleration is used to calculate a mechanical response interval and the mechanical response interval is compared to a desired mechanical response interval. The AV interval is adjusted until the mechanical response interval is equal to the desired mechanical response interval.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: March 1, 2016
    Assignee: Medtronic, Inc.
    Inventors: Rajan Prakash, Aleksandre T. Sambelashvili
  • Publication number: 20160051821
    Abstract: Provided herewith are methods and apparatus for optimizing an atrioventricular (AV) pacing delay interval. One manner described involves dynamically programming an AV interval in cardiac resynchronization therapy (CRT) device having a rate-adaptive AV (RAAV) feature in such a way that not less than a minimum AV interval is maintained. That is, the AV interval is not allowed to be reduced so much that the P-wave is truncated by the QRS complex. In this form of the invention, the AV interval is reduced by one millisecond per one bpm increase in heart rate (and vice versa for reducing heart rate) but maintained at a value calculated from the end of the P-wave (PWend) and the beginning of the QRS complex (QRSbeg) or delivery of a ventricular pacing stimulus or to the end of the end of the QRS complex (QRSend).
    Type: Application
    Filed: June 24, 2015
    Publication date: February 25, 2016
    Inventors: Aleksandre T. Sambelashvili, Thomas J Mullen
  • Patent number: RE48197
    Abstract: A leadless pacing device (LPD) includes a motion sensor configured to generate a motion signal as a function of heart movement. The LPD is configured to analyze the motion signal within an atrial contraction detection window that begins an atrial contraction detection delay period after activation of the ventricle, and detect a contraction of an atrium of the heart based on the analysis of the motion signal within the atrial contraction detection window. If the LPD does not detect a ventricular depolarization subsequent to the atrial contraction, e.g., with an atrio-ventricular (AV) interval beginning when the atrial contraction was detected, the LPD delivers a ventricular pacing pulse.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: September 8, 2020
    Assignee: Medtronic, Inc.
    Inventors: Yong K. Cho, Aleksandre T. Sambelashvili, Todd J. Sheldon
  • Patent number: RE48319
    Abstract: Techniques and systems for monitoring cardiac arrhythmias and delivering electrical stimulation therapy using a subcutaneous device (e.g. subcutaneous implantable (SD)) is described. In one or more other embodiments, SD is implanted into a patient's heart. Electrical signals are then sensed which includes moderately lengthened QRS duration data from the patient's heart. A determination is made as to whether cardiac resynchronization pacing therapy (CRT pacing) is appropriate based upon the moderately lengthened QRS duration in the sensed electrical signals. The CRT pacing pulses are delivered to the heart using electrodes. In one or more embodiments, the SD can switch between fusion pacing and biventricular pacing based upon data (e.g. moderately lengthened QRS, etc.) sensed from the heart.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 24, 2020
    Assignee: Medtronic, Inc.
    Inventor: Aleksandre T. Sambelashvili