Patents by Inventor Alessandra Luchini
Alessandra Luchini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240142444Abstract: The invention relates to a relates to a highly sensitive, non-invasive diagnostic method for detection infectious diseases. In one embodiment, the invention relates to novel rapid, self-working, visual field test for a panel of disease specific derived biomarkers. In one embodiment, the invention comprises a collecting device comprising a collapsible non hygroscopic net tethered with immobilized nanoparticles to capture and concentrate a target analyte present in a fluid; wherein the nanoparticle comprises a core and a shell, wherein the core comprises a molecular bait. The invention also relates to identification of biomarkers for identification of various pathogenic diseases.Type: ApplicationFiled: June 25, 2020Publication date: May 2, 2024Inventors: Lance LIOTTA, Marissa A. HOWARD, Alessandra Luchini KUNKEL, Sameen YUSUF, Sara SHARIF, Ruben MAGNI
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Publication number: 20240110852Abstract: Compositions and methods for the simulataneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: ApplicationFiled: September 1, 2023Publication date: April 4, 2024Applicant: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Lance LIOTTA, Virginia ESPINA, Nitin AGRAWAL, Alessandra Luchini KUNKEL
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Publication number: 20240091741Abstract: The present disclosure relates to compositions, devices and methods for removing/filtering out microorganisms from a given fluid. The composition of the present invention comprises a non-water imbibing, biocompatible filament and at least one affinity ligand that is capable of capturing the microorganism(s). The invention also discloses methods for detection, diagnosis, and/or treatment.Type: ApplicationFiled: July 18, 2023Publication date: March 21, 2024Inventors: Alessandra Luchini Kunkel, Silvia Isabel Cachaco, Rocío Solange Prisby, Amanda Haymond Still, Lance Liotta, Luisa Gregori, Cyrus Bett
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Publication number: 20240084044Abstract: The present disclosure relates to heteromultivalent nucleic acid scaffolds and peptides, and to compositions comprising the scaffolds and peptides, and to methods for preparing and using the scaffolds and peptides. The present disclosure also relates to use of the scaffolds, peptides, and compositions for preventing or disrupting interactions between molecules, in particular protein-protein interactions, in particular for the treatment or prevention of disease, in particular cancer, such as breast cancer.Type: ApplicationFiled: September 5, 2023Publication date: March 14, 2024Inventors: Amanda Haymond Still, Remi Veneziano, Jessica A. Roman, Lance Liotta, Alessandra Luchini Kunkel
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Patent number: 11912740Abstract: Methods for isolating proteins from a honey sample are provided. The methods include contacting the honey sample with a substrate functionalized with one or more reactive dyes and recovering proteins associated with the substrate. Methods for detecting proteins in a honey sample and assessing the risk of colony collapse disorder are also provided.Type: GrantFiled: December 9, 2020Date of Patent: February 27, 2024Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Rocio Solange Cornero, Alessandra Luchini Kunkel, Lance A. Liotta, Claudius Mueller
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Patent number: 11857169Abstract: A collapsible sample collection device with a novel, collapsible 3D capture open affinity net dispersed throughout the volume of the container, said net with tethered affinity moieties, is designed to address the need for low-cost, simple harvesting and concentration of diagnostic analytes that generally does not require any ancillary equipment. The collection device generally permits analytes of interest to be efficiently harvested from body fluid samples, in one step, concentrated, collapsed into a flat mailing size, and protected from degradation without the need for traditional cold chain technologies. The concentration factor will increase sensitivity by several orders of magnitude when coupled with any type of downstream analyte measurement, including point of care testing. The collection device, in various embodiments, obviates the need for handling transport or storage of the fluid portion of the body fluid sample (e.g. blood, urine, saliva, etc.Type: GrantFiled: April 23, 2019Date of Patent: January 2, 2024Assignee: George Mason Research Foundation, Inc.Inventors: Sameen Yusuf, Marissa A. Howard, Sara Sharif, Kelsey Mitchell, Amanda Haymond Still, Ngoc Bao Vuong, Alessandra Luchini Kunkel, Lance A. Liotta
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Publication number: 20230417637Abstract: Laser Capture Microdissection devices and methods are provided. A Laser Capture Microdissection device contains a transmissive film and a transfer film. The transmissive film includes a first material configured to transmit laser energy. The transfer film includes a second material configured to absorb UV-laser energy. The transfer film contains an absorptive substance to absorb UV-laser energy and convert it into heat.Type: ApplicationFiled: November 9, 2021Publication date: December 28, 2023Applicant: George Mason Research Foundation, INC.Inventors: Lance A. LIOTTA, Alessandra Luchini KUNKEL, Marissa Ashton HOWARD, Amanda Haymond STILL, Harini SOMANCHI, Philip Andrew PAPPALARDO
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Publication number: 20230384187Abstract: A liquid including an organic component, a stabilization component, and a preservation component is provided. The organic component, the stabilization component, and the preservation component are different components. The organic component present in the liquid includes a volatile organic solution with a refractive index of 1.5 or below. Further, the liquid is a visualization solution that provides a resolving power of a lens by 1/1.5.Type: ApplicationFiled: November 10, 2021Publication date: November 30, 2023Applicant: George Mason Research Foundation, Inc.Inventors: Lance A. LIOTTA, Alessandra Luchini KUNKEL, Marissa Ashton HOWARD, Amanda Haymond STILL, Amanda Lynn STILL, Virginia ESPINA
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Patent number: 11747242Abstract: Compositions and methods for the simultaneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: GrantFiled: May 20, 2020Date of Patent: September 5, 2023Assignee: George Mason Research Foundation, Inc.Inventors: Lance Liotta, Virginia Espina, Nitin Agrawal, Alessandra Luchini Kunkel
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Patent number: 11493518Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.Type: GrantFiled: September 25, 2018Date of Patent: November 8, 2022Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Alessandra Luchini Kunkel, Lance Liotta, Virginia Espina
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Patent number: 11424409Abstract: A first aspect provides a topological quantum computing device comprising a network of semiconductor-superconductor nanowires, each nanowire comprising a length of semiconductor formed over a substrate and a coating of superconductor formed over at least part of the semiconductor; wherein at least some of the nanowires further comprise a coating of ferromagnetic insulator disposed over at least part of the semiconductor. A second aspect provides a method of fabricating a quantum or spintronic device comprising a heterostructure of semiconductor and ferromagnetic insulator, by: forming a portion of the semiconductor over a substrate in a first vacuum chamber, and growing a coating of the ferromagnetic insulator on the semiconductor by epitaxy in a second vacuum chamber connected to the first vacuum chamber by a vacuum tunnel, wherein the semiconductor comprises InAs and the ferromagnetic insulator comprises EuS.Type: GrantFiled: December 28, 2020Date of Patent: August 23, 2022Assignee: Microsoft Technology Licensing, LLCInventors: Peter Krogstrup Jeppesen, Yu Liu, Alessandra Luchini
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Publication number: 20220221454Abstract: An embodiment relates to a reagent buffer comprising a zwitterionic sulfonic solution, a non-ionic surfactant solution, and a buffer solution, wherein the reagent buffer has a pH range of about 7.0 to about 8.0 and a circular dichroism with an absorbance peak more than 0 at 190 nm and 225 nm. In an embodiment, the reagent buffer is configured to be a reagent buffer for a lateral flow immunoassay for detection of COVID-19.Type: ApplicationFiled: January 7, 2022Publication date: July 14, 2022Inventors: Lance A. LIOTTA, Alessandra Luchini Kunkel, Marissa Ashton Howard, Amanda Haymond Still, Ghaliah Abdraboh M. Alluhaibi, Hannah Elizabeth Steinberg
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Publication number: 20220064259Abstract: The present disclosure relates to compounds, complexes, compositions, kits and methods for determining interacting and/or binding sites between e.g., proteins, proteins and nucleic acids, proteins and small molecules, or intrachain protein domains. The disclosure provides rapid and direct positive identification of the contact interface region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.Type: ApplicationFiled: January 3, 2020Publication date: March 3, 2022Inventors: Lance Liotta, Alessandra Luchini Kunkel, Amanda Still, Mikell Paige
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Publication number: 20210231652Abstract: A labeling molecule is provided. The labeling molecule includes a compound of the following formula: CA-(M)-A]n. In the formula, “A” is a label anchor moiety, “M” is an identification moiety, and “CA” is a coordination agent moiety. The label anchor is an organic moiety that binds to a surface of a targeted biomolecule through noncovalent or covalent interactions at one end of the label anchor and binds a coordination moiety. The coordination moiety includes an identification moiety at an end that is distal to the end conjugated to the surface of the targeted biomolecule, and the subscript “n” is 1, 2, 3, 4, or 5.Type: ApplicationFiled: May 30, 2019Publication date: July 29, 2021Applicant: George Mason Research Foundation, Inc.Inventors: Lance A. LIOTTA, Alessandra Luchini KUNKEL, Amanda N. Haymond STILL
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Publication number: 20210198308Abstract: Methods for isolating proteins from a honey sample are provided. The methods include contacting the honey sample with a substrate functionalized with one or more reactive dyes and recovering proteins associated with the substrate. Methods for detecting proteins in a honey sample and assessing the risk of colony collapse disorder are also provided.Type: ApplicationFiled: December 9, 2020Publication date: July 1, 2021Inventors: Rocio Solange Cornero, Alessandra Luchini Kunkel, Lance A. Liotta, Claudius Mueller
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Publication number: 20210132049Abstract: A device and system for conducting accurate diagnosis of states of disease or health, including cancer, with high sensitivity and specificity is described. The system employs a portable cassette-based testing system which is configured to detect pp analytes captured by hydrogel particles equipped with affinity bait(s) and an amplification reporter system. The affinity baits bind to a wide range of analytes, including: metabolites, proteins, nucleic acids, lipids, hormones, cytokines, growth factors, biomarkers, virus particles, exosomes, bacteria, fungi, drug compounds, synthetic organic compounds, volatile odorants, toxicants, and pollutants. The affinity baits bind with extremely high affinity, preserving the captured analyte. This system can increase the sensitivity of detection of said analytes up to ten-thousand-fold.Type: ApplicationFiled: May 29, 2018Publication date: May 6, 2021Inventors: Lance A. Liotta, Alessandra Luchini Kunkel, Marissa A. Howard, Sameen Yusuf, Sara Sharif, Rohit L. Madhu
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Publication number: 20210119125Abstract: A first aspect provides a topological quantum computing device comprising a network of semiconductor-superconductor nanowires, each nanowire comprising a length of semiconductor formed over a substrate and a coating of superconductor formed over at least part of the semiconductor; wherein at least some of the nanowires further comprise a coating of ferromagnetic insulator disposed over at least part of the semiconductor. A second aspect provides a method of fabricating a quantum or spintronic device comprising a heterostructure of semiconductor and ferromagnetic insulator, by: forming a portion of the semiconductor over a substrate in a first vacuum chamber, and growing a coating of the ferromagnetic insulator on the semiconductor by epitaxy in a second vacuum chamber connected to the first vacuum chamber by a vacuum tunnel, wherein the semiconductor comprises InAs and the ferromagnetic insulator comprises EuS.Type: ApplicationFiled: December 28, 2020Publication date: April 22, 2021Applicant: Microsoft Technology Licensing, LLCInventors: Peter Krogstrup Jeppesen, Yu Liu, Alessandra Luchini
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Patent number: 10927155Abstract: In one aspect, the invention relates to compositions comprising peptides and/or peptidomimetic compounds, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, arthritis, obstructive lung disease, psoriasis, asthma, a defect in hematopoiesis, a neoplasia, a fungal infection, a parasitic infection, or an autoimmune disease, such as, but not limited to, rheumatoid arthritis, atopic allergy, anaphylaxis, psoriasis, asthma, lupus erythematosis, a myeloid cell disorder, or a eosinophil cell disorder. In an aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the ST2 and IL33 receptor/cytokine complexes. In a further aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the IL-1R1 and IL-1? receptor/cytokine complexes.Type: GrantFiled: November 18, 2016Date of Patent: February 23, 2021Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Lance Liotta, Alessandra Luchini, Virginia Espina, Mikell Paige
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Patent number: 10879464Abstract: A first aspect provides a topological quantum computing device comprising a network of semiconductor-superconductor nanowires, each nanowire comprising a length of semiconductor formed over a substrate and a coating of superconductor formed over at least part of the semiconductor; wherein at least some of the nanowires further comprise a coating of ferromagnetic insulator disposed over at least part of the semiconductor. A second aspect provides a method of fabricating a quantum or spintronic device comprising a heterostructure of semiconductor and ferromagnetic insulator, by: forming a portion of the semiconductor over a substrate in a first vacuum chamber, and growing a coating of the ferromagnetic insulator on the semiconductor by epitaxy in a second vacuum chamber connected to the first vacuum chamber by a vacuum tunnel, wherein the semiconductor comprises InAs and the ferromagnetic insulator comprises EuS.Type: GrantFiled: January 11, 2019Date of Patent: December 29, 2020Assignee: Microsoft Technology Licensing, LLCInventors: Peter Krogstrup Jeppesen, Yu Liu, Alessandra Luchini
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Patent number: D912270Type: GrantFiled: April 12, 2019Date of Patent: March 2, 2021Assignee: GEORGE MASON RESEARCH FOUNDATON, INC.Inventors: Lance Liotta, Alessandra Luchini, Amanda N. Haymond Still