Patents by Inventor Alessandra Luchini
Alessandra Luchini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10879464Abstract: A first aspect provides a topological quantum computing device comprising a network of semiconductor-superconductor nanowires, each nanowire comprising a length of semiconductor formed over a substrate and a coating of superconductor formed over at least part of the semiconductor; wherein at least some of the nanowires further comprise a coating of ferromagnetic insulator disposed over at least part of the semiconductor. A second aspect provides a method of fabricating a quantum or spintronic device comprising a heterostructure of semiconductor and ferromagnetic insulator, by: forming a portion of the semiconductor over a substrate in a first vacuum chamber, and growing a coating of the ferromagnetic insulator on the semiconductor by epitaxy in a second vacuum chamber connected to the first vacuum chamber by a vacuum tunnel, wherein the semiconductor comprises InAs and the ferromagnetic insulator comprises EuS.Type: GrantFiled: January 11, 2019Date of Patent: December 29, 2020Assignee: Microsoft Technology Licensing, LLCInventors: Peter Krogstrup Jeppesen, Yu Liu, Alessandra Luchini
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Publication number: 20200333220Abstract: Compositions and methods for the simulataneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: ApplicationFiled: May 20, 2020Publication date: October 22, 2020Applicant: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Lance LIOTTA, Virginia ESPINA, Nitin AGRAWAL, Alessandra Luchini KUNKEL
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Publication number: 20200227636Abstract: A first aspect provides a topological quantum computing device comprising a network of semiconductor-superconductor nanowires, each nanowire comprising a length of semiconductor formed over a substrate and a coating of superconductor formed over at least part of the semiconductor; wherein at least some of the nanowires further comprise a coating of ferromagnetic insulator disposed over at least part of the semiconductor. A second aspect provides a method of fabricating a quantum or spintronic device comprising a heterostructure of semiconductor and ferromagnetic insulator, by: forming a portion of the semiconductor over a substrate in a first vacuum chamber, and growing a coating of the ferromagnetic insulator on the semiconductor by epitaxy in a second vacuum chamber connected to the first vacuum chamber by a vacuum tunnel, wherein the semiconductor comprises InAs and the ferromagnetic insulator comprises EuS.Type: ApplicationFiled: January 11, 2019Publication date: July 16, 2020Applicant: Microsoft Technology Licensing, LLCInventors: Peter Krogstrup Jeppesen, Yu Liu, Alessandra Luchini
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Patent number: 10697866Abstract: Compositions and methods for the simulataneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: GrantFiled: April 26, 2019Date of Patent: June 30, 2020Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Lance Liotta, Virginia Espina, Nitin Agrawal, Alessandra Luchini
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Publication number: 20190365921Abstract: A system and method configured to achieve hydrogel particle treatment for the reduction of metastatic burden in an immunocompetent syngeneic mouse model is described. The system seeks to achieve methodic optimization for the extraction and purification of extracellular vesicles (EVs) from cultured cells as well as from fresh breast cancer interstitium. Similarly, the system provides for lymph node remodeling by human breast cancer EVs in a humanized mouse model. Hydrogel particles are employed to convey cytokine releasing and EV-displaying treatment to afflicted bodies.Type: ApplicationFiled: June 3, 2019Publication date: December 5, 2019Inventors: LANCE A. LIOTTA, ALESSANDRA LUCHINI KUNKEL, BENJAMIN LEPENE, FATAH KASHANCHI
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Publication number: 20190352351Abstract: In one aspect, the invention relates to compositions comprising peptides and/or peptidomimetic compounds, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, arthritis, obstructive lung disease, psoriasis, asthma, a defect in hematopoiesis, a neoplasia, a fungal infection, a parasitic infection, or an autoimmune disease, such as, but not limited to, rheumatoid arthritis, atopic allergy, anaphylaxis, psoriasis, asthma, lupus erythematosis, a myeloid cell disorder, or a eosinophil cell disorder. In an aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the ST2 and IL33 receptor/cytokine complexes. In a further aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the IL-1R1 and IL-1? receptor/cytokine complexes.Type: ApplicationFiled: November 18, 2016Publication date: November 21, 2019Inventors: Lance LIOTTA, Alessandra LUCHINI, Virginia ESPINA, Mikell PAIGE
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Publication number: 20190250079Abstract: Compositions and methods for the simulataneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: ApplicationFiled: April 26, 2019Publication date: August 15, 2019Inventors: LANCE LIOTTA, VIRGINIA ESPINA, NITIN AGRAWAL, ALESSANDRA LUCHINI
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Patent number: 10324008Abstract: Compositions and methods for the simultaneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: GrantFiled: December 22, 2016Date of Patent: June 18, 2019Assignee: GEORGE MASON RESEARCH FOUNDATIONInventors: Lance Liotta, Virginia Espina, Nitin Agrawal, Alessandra Luchini
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Publication number: 20190033319Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.Type: ApplicationFiled: September 25, 2018Publication date: January 31, 2019Applicant: George Mason Research Foundation, Inc.Inventors: Alessandra Luchini, Lance Liotta, Virginia Espina
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Patent number: 10126304Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.Type: GrantFiled: January 15, 2014Date of Patent: November 13, 2018Assignee: George Mason Research Foundation, Inc.Inventors: Alessandra Luchini, Lance Liotta, Virginia Espina
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Publication number: 20170176301Abstract: Compositions and methods for the simultaneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: ApplicationFiled: December 22, 2016Publication date: June 22, 2017Inventors: Lance Liotta, Virginia Espina, Nitin Agrawal, Alessandra Luchini
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Patent number: 9383299Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.Type: GrantFiled: February 25, 2013Date of Patent: July 5, 2016Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Alessandra Luchini Kunkel, Lance Liotta, Emanuel Petricoin, Barney Bishop, Francesco Meani, Claudia Fredolini, Thomas M Dunlap, Alexis Patanarut
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Publication number: 20150338417Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.Type: ApplicationFiled: January 15, 2014Publication date: November 26, 2015Inventors: Alessandra Luchini, Lance Liotta, Virginia Espina
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Patent number: 9012240Abstract: An immunoassay device incorporating porous polymeric capture nanoparticles within either the sample collection vessel or pre-impregnated into a porous substratum within fluid flow path of the analytical device is presented. This incorporation of capture particles within the immunoassay device improves sensitivity while removing the requirement for pre-processing of samples prior to loading the immunoassay device. A preferred embodiment is coreshell bait containing capture nanoparticles which perform three functions in one step, in solution: a) molecular size sieving, b) target analyte sequestration and concentration, and c) protection from degradation. The polymeric matrix of the capture particles may be made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle.Type: GrantFiled: August 26, 2009Date of Patent: April 21, 2015Assignee: George Mason Research Foundation, Inc.Inventors: Lance A. Liotta, Alessandra Luchini, Emanuel F. Petricoin, Virginia Espina
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Publication number: 20140045274Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.Type: ApplicationFiled: February 25, 2013Publication date: February 13, 2014Inventors: Alessandra Luchini Kunkel, Lance Liotta, Emanuel Petricoin, Barney Bishop, Francesco Meani, Claudia Fredolini, Thomas M. Dunlap, Alexis Patanarut
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Patent number: 8497137Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.Type: GrantFiled: August 19, 2008Date of Patent: July 30, 2013Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Caterina Longo, Virginia Espina, Alexis Patanarut
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Publication number: 20130085076Abstract: The invention relates to both a sensitive method for the capture and detection of low-abundance Borrelia burgdorferi (Bb) bacterial antigens allowing for the diagnosis of Lyme Disease using standard immunoassays. Furthermore, this invention allows the antigen to be identified in a sample of urine, serum, or other biological fluids isolated from humans and animals. The invention provides a method to capture, concentrate, separate and specifically quantify the abundance of Bb antigens using immunoassays. The detection of Bb Outer Surface Protein A is presented as an example of the disclosed invention. High sensitivity levels, low cost and easily collected biofluids allow this technology to reach patients in clinics as well as POC applications for the early detection of Lyme disease prior to seroconversion. A kit containing necessary reagents and the method for diagnosis, monitoring or assessing lyme disease using an immunoassay such as an ELISA, western blot or RPPMA is disclosed.Type: ApplicationFiled: December 1, 2010Publication date: April 4, 2013Inventors: Temple Douglas, Alessandra Luchini, Claudia Fredolini, Davide Tamburro, Lance Liotta
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Patent number: 8382987Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.Type: GrantFiled: August 19, 2008Date of Patent: February 26, 2013Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Francesco Meani, Claudia Fredolini, Thomas M Dunlap, Alexis Patanarut
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Publication number: 20120164749Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.Type: ApplicationFiled: August 19, 2008Publication date: June 28, 2012Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Caterina Longo, Virginia Espina, Alexis Patanarut
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Publication number: 20120107959Abstract: This invention describes the identification of novel organic dye chemistries that can be used as affinity baits to capture proteins and other biomolecules useful in the fields of medical diagnostics, environmental science, toxicology, and infectious disease. Incorporation of unique affinity dye compounds within hydrogel capture particles improves analyte yield and preanalytical precision, and stabilizes the analyte against degradation, while increasing measurement sensitivity. The particles in this invention can be used for routine clinical testing as well as for discovery of low abundance disease biomarkers. Example hydrogel particles containing new high affinity bait chemistries were used to identify a new set of human serum biomarkers.Type: ApplicationFiled: June 21, 2010Publication date: May 3, 2012Inventors: Lance Liotta, Virginia Espina, Alessandra Luchini, Davide Tamburro