Abstract: An open channel microfluidic device for use in tissue culture is described. The open channel microfluidic device is used as a patterning rail in a cell culture system to create suspended tissues with cells suspended in a hydrogel. The present disclosure also provides methods of preparing a tissue using the open channel microfluidic device described herein.

Abstract: A display assembly for preventing delamination of electronic display layers includes an electronic display subassembly at a structural framework having multiple optical layers and/or films (“the layers”). A first passageway is located between a cover forward of the electronic display subassembly and a forward one of the layers. A second passageway is located rearward of the layers. A third passageway is fluidly connected to an entrance and an exit of each of the first and second passageways. The first, second, and third passageways define, at least in part, a continuous airflow pathway. A fan unit positioned proximate to the entrance to each of the first and second passageways moves gas through the continuous airflow pathway, including into the first and second passageways in a same primary direction to generate compressive forces at the layers.

Abstract: A system and method for matching a plurality of components to a plurality of printed circuit board (PCB), including: characterizing the warpage characteristics of the plurality of components; characterizing the warpage characteristics of a site of the plurality of PCBs where the component will be placed; determining viable component and PCB pairings based upon the component warpage characteristics and the PCB warpage characteristics; and assembling the pairs of components and PCBs.

Abstract: A quantum computing system comprises a classical computing entity, a controller, and a quantum processor. The controller is configured to control operation of the quantum processor and communicate with the computing entity. The controller causes performance of syndrome circuit segments to generate syndromes of logical qubits. The syndrome circuit segment is performed at least partially by causing performance of a sequence of transportation operations and at-least-two-physical-qubits interactions. Each transportation operation of the sequence causes physical transport of at least one of a respective data qubit of the logical qubit or a respective ancilla qubit into a respective interaction zone defined by the quantum processor. A respective at-least-two-physical-qubits interaction is performed within the respective interaction zone.

Abstract: A circuit assembly, including: an integrated circuit (IC) with a plurality of connection pads; a ball grid array (BGA) including a plurality of solder balls arranged in an array, where plurality of solder balls are configured to connect the plurality of connections pads to a plurality of connections pads on a PCB; and a BGA spacer configured to fit among the plurality of solder balls, wherein the BGA spacer has a width based upon a height and spacing of the plurality of solder balls and a height based upon a height and spacing of the plurality of solder balls and a minimum distance between the IC and the PCB to prevent shorting of adjacent solder balls.

Abstract: A method includes receiving a clinical data table for a patient. The clinical data table stores clinical data associated with the patient in tabular form. The method also includes extracting, from the clinical data table, one or more categorical features and one or more continuous features, and determining, using a clinical prediction model, one or more predicted clinical outcomes for the patient based on the one or more categorical features and the one or more continuous features extracted from the clinical data table. The method also includes providing, for output from a client device associated with a user, the one or more predicted clinical outcomes for the patient.

Abstract: A video monitoring system can include multiple collectors to receive video beacon data from multiple video monitoring interface modules. At least one beacon stream is connected to receive data from multiple collectors. A processing module receives the beacon stream and provides a real-time event stream used for real-time data analysis and a video view stream used for long-term data analysis.

Abstract: A method includes obtaining a first training data set including unannotated multi-dimensional medical images and executing a self-supervised masked image modeling (MIM) training process to pre-train an image encoder on the first training data set. The method also includes obtaining a second training data set that includes annotated multi-dimensional medical images. Here, each annotated multi-dimensional medical image includes a plurality of image voxels each paired with a corresponding ground-truth label indicating a class the corresponding image voxel belongs to. The method also includes executing a supervised training process to train an image analysis model on the second training data set to teach the image analysis model to learn how to predict the corresponding ground-truth labels for the plurality of image voxels of each annotated multi-dimensional medical image. The image analysis model incorporates the pre-trained image encoder.

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).

Abstract: The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

Abstract: A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

Abstract: A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

Abstract: The disclosed apparatus may include at least one physical extension handle that connects to at least one ejector that facilitates securing a line card to a chassis of a telecommunications system and ejecting the line card from the chassis of the telecommunications system. The physical extension handle may, when connected to the ejector, extend the ejector such that a user is able to access the ejector by way of the physical extension handle to secure the line card to or eject the line card from the chassis of the telecommunications system using the physical extension handle. Additionally or alternatively, the physical extension handle may facilitate physically supporting one or more communication cables connected to the line card in a horizontal orientation such that the communication cables avoid hanging down vertically directly from the chassis. Various other apparatuses and systems are also disclosed.