Abstract: An injection molding apparatus comprises a support base and a mold carrier removably mounted to the support base. The mold carrier includes a mounting plate with attachment features for engaging the support base. A mold with two mold plates is slidably mounted to the mounting 5 plate. A clamp is operable to move the plates between open and closed positions. In the closed position, the plates abut one another. In the open position, the plates are spaced apart for removing molded articles.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: An interactive toy system is shown and described. The toy system includes a double walled flask adapted to be connected to a base forming an internal space capable of holding an object or a figurine. When an empty space between the double walls is filled with an opaque fluid, it gives the player the impression that the whole flask is filled with such fluid. The toy system includes a smoke generating system, light emitting LEDs and a speaker. During the controlled play process, ingredients are added to an isolated fluid chamber on top of the flask. The operation and the special effects from the smoke, the sound, the light, and the phenomenon in the fluid chamber gives the impression that the creature is being created inside the opaque flask. When the process is concluded and the fluid in the flask is drained, the figurine inside the flask is revealed.

Abstract: A machine tool for the machining of elongate workpieces includes a workpiece support column having workpiece support components for supporting a first workpiece and second workpiece support components for supporting a second workpiece. The first workpiece support component and the second workpiece support component are arranged for supporting the first workpiece vertically above the second workpiece. The workpiece support column is rotatable around a vertical axis so as to shift the workpieces between the machining station and a station for loading and unloading of workpieces. The workpiece support component include a drive element for applying torque to the workpieces for machining of the workpieces by turning. A motor and chuck assembly and a method of machining workpieces are related.

Abstract: A method of oxygenating a benzylic C—H bond is provided. The method comprises light induced activation of an initiator and subsequent reaction with oxygen, resulting in the formation of free radicals. Subsequently, free radicals catalyze the reaction of the benzylic C—H bond with oxygen, thereby forming an oxygenated compound.

Abstract: A vehicle seat actuator includes an electric motor and a gear set that connects the drive motor to the seat and transmits the output of the motor to the vehicle seat. The drive motor and gear set are each disposed in an individual, dedicated housing component. The individual housing components are then assembled together to provide the actuator. The housing components are maintained in the assembled configuration using snap fit mechanical fasteners. Each snap-fit fastener includes a receiving portion provided on one housing component and an insertion portion provided on the other housing component. The receiving portion may be a slot formed in the gear housing that is partially obstructed by an elastic member, while insertion portion is an ear that protrudes from an outer surface of the drive motor housing and forms both a snap-fit engagement with the elastic member and a press-fit engagement with the slot.

Abstract: A mission planning method for use with a weapon is disclosed. The method comprises: obtaining a first training data set describing the performance of the weapon; using the first training data set and a Gaussian Process (GP) or Neural Network to obtain a first surrogate model giving a functional approximation of the performance of the weapon; and providing the first surrogate model to a weapons system for use in calculating a performance characteristic of the weapon during combat operations.

Abstract: A vehicle seat actuator includes an electric motor and a gear set that connects the drive motor to the seat and transmits the output of the motor to the vehicle seat. The drive motor and gear set are each disposed in an individual, dedicated housing component. The individual housing components are then assembled together to provide the actuator. The housing components are maintained in the assembled configuration using snap fit mechanical fasteners. Each snap-fit fastener includes a receiving portion provided on one housing component and a retaining portion provided on the other housing component. The receiving portion may be a blind hole formed in the drive motor housing that is partially obstructed by an elastic member, while the retaining component is a latch that protrudes from an outer surface of the gear housing and forms a snap-fit engagement with the elastic member.

Abstract: A mission planning method for use with a weapon is disclosed. The method comprises: obtaining a first training data set describing the performance of the weapon; using the first training data set and a Gaussian Process (GP) or Neural Network to obtain a first surrogate model giving a functional approximation of the performance of the weapon; and providing the first surrogate model to a weapons system for use in calculating a performance characteristic of the weapon during combat operations.

Abstract: A vehicle seat actuator includes an electric motor and a gear set that connects the drive motor to the seat and transmits the output of the motor to the vehicle seat. The drive motor and gear set are each disposed in an individual, dedicated housing component. The individual housing components are then assembled together to provide the actuator. The housing components are maintained in the assembled configuration using snap fit mechanical fasteners. Each snap-fit fastener includes a receiving portion provided on one housing component and a retaining portion provided on the other housing component. The receiving portion may be a through hole formed in the drive motor housing, while the retaining component protrudes from an outer surface of the gear housing and forms a snap-fit engagement with the receiving portion.

Abstract: An actuator housing is configured to receive an electric motor and a gear set that modifies the output of the motor. The actuator housing includes a gear housing that supports the gear set for rotation. The gear set includes a worm gear that is driven by the motor and has an opening that is concentric with a rotational axis of the gear. The gear housing includes a container and a cover that closes an open end of the container. The container houses the gear and defines a hollow gear shaft that extends through the gear opening. The cover is secured to the open end of the gear housing via a snap-fit mechanical connection between the cover and the gear shaft.

Abstract: A vehicle seat actuator includes an electric motor and a gear set that connects the drive motor to the seat and transmits the output of the motor to the vehicle seat. The drive motor and gear set are each disposed in an individual, dedicated housing component. The individual housing components are then assembled together to provide the actuator. The housing components are maintained in the assembled configuration using snap fit mechanical fasteners. Each snap-fit fastener includes a receiving portion provided on one housing component and an insertion portion provided on the other housing component. The receiving portion may be a slot formed in the gear housing that is partially obstructed by an elastic member, while insertion portion is an ear that protrudes from an outer surface of the drive motor housing and forms both a snap-fit engagement with the elastic member and a press-fit engagement with the slot.

Abstract: A vehicle seat actuator includes an electric motor and a gear set that connects the drive motor to the seat and transmits the output of the motor to the vehicle seat. The drive motor and gear set are each disposed in an individual, dedicated housing component. The individual housing components are then assembled together to provide the actuator. The housing components are maintained in the assembled configuration using snap fit mechanical fasteners. Each snap-fit fastener includes a receiving portion provided on one housing component and a retaining portion provided on the other housing component. The receiving portion may be a through hole formed in the drive motor housing, while the retaining component protrudes from an outer surface of the gear housing and forms a snap-fit engagement with the receiving portion.

Abstract: A vehicle seat actuator includes an electric motor and a gear set that connects the drive motor to the seat and transmits the output of the motor to the vehicle seat. The drive motor and gear set are each disposed in an individual, dedicated housing component. The individual housing components are then assembled together to provide the actuator. The housing components are maintained in the assembled configuration using snap fit mechanical fasteners. Each snap-fit fastener includes a receiving portion provided on one housing component and a retaining portion provided on the other housing component. The receiving portion may be a blind hole formed in the drive motor housing that is partially obstructed by an elastic member, while the retaining component is a latch that protrudes from an outer surface of the gear housing and forms a snap-fit engagement with the elastic member.

Abstract: An actuator housing is configured to receive an electric motor and a gear set that modifies the output of the motor. The actuator housing includes a gear housing that supports the gear set for rotation. The gear set includes a worm gear that is driven by the motor and has an opening that is concentric with a rotational axis of the gear. The gear housing includes a container and a cover that closes an open end of the container. The container houses the gear and defines a hollow gear shaft that extends through the gear opening. The cover is secured to the open end of the gear housing via a snap-fit mechanical connection between the cover and the gear shaft.

Abstract: A housing a housing container, a housing cover configured to close an open end of the housing container and a snap-fit fastener that secures a rim of the housing cover to a sidewall of the housing container. The housing container includes a base and a sidewall that protrudes from the base. The fastener includes an elastic clip that is disposed on an outer surface of the sidewall and a rigid lug that protrudes from the cover and engages the clip. The clip has a U-shaped plate portion that extends in parallel to the sidewall and defines clip opening. The lug includes a ridge that protrudes into the clip opening and engages the plate portion. The plate portion is dimensioned so that an outer edge of the plate portion is disposed no further from the container base than the sidewall free edge.

Abstract: Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.

Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].

Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].