Abstract: Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.

Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].

Abstract: A method of storing data items included in an email message for access by a user in conjunction with an accessing by the user of a profile of a member of the social-networking system is disclosed. An email message from an additional user of a social-networking system is received by the user of the social-networking system. A data item included in the email message is identified upon which a correspondence between the data item included in the email message and a profile of a member of the social-networking system may be determined. An additional data item included in the email message is stored such that the additional data item is accessible by the user of the social-networking system in conjunction with an accessing by the user of the profile of the member.

Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].

Abstract: A method of storing data items included in an email message for access by a user in conjunction with an accessing by the user of a profile of a member of the social-networking system is disclosed. An email message from an additional user of a social-networking system is received by the user of the social-networking system. A data item included in the email message is identified upon which a correspondence between the data item included in the email message and a profile of a member of the social-networking system may be determined. An additional data item included in the email message is stored such that the additional data item is accessible by the user of the social-networking system in conjunction with an accessing by the user of the profile of the member.

Abstract: A method of enabling a knowledge management community. A community is originated based on a vision of values and benefits that can be realized from the organized sharing of knowledge within a common group of people. The group is defined based on subject matter, interest, geography, or any other category. Based on the vision of a community, an initial definition of the community is created, including a community charter. Based on the community charter, the community is designed. The design of the community includes creating a matrix showing processes performed by members of the community and the outcomes of these processes, developing knowledge maps that show the knowledge used and created in performing processes, and defining metrics to measure the benefit derived from the sharing of knowledge within the community.

Abstract: A rapid measuring system for the determination of the concentration of propofol in the respiratory flow, which can be designed in a compact form, has the features of a breathing gas line (1) including a breathing gas sensor (2) detecting the respiration, wherein the breathing gas sensor (2) is connected to an evaluating unit (3), a propofol sensor (5) with a downstream pump (6) is in gas flow connection with the breathing gas line (1), wherein the evaluating unit (3) is connected with the propofol sensor (5) and the pump (6), so that the evaluating unit (3) actuates the pump (6) for breathing gas sampling depending on the signal of the breathing gas sensor (2), and the propofol sensor (5) sends a measured signal for the concentration of propofol in the breathing gas to the evaluating unit (3).

Abstract: A method is disclosed for analyzing an oil and gas production project with a computer system. Using a computer program, a user inputs characteristics of systems for the project and inputs characteristics of the expected production of the project, such as production life (years) and the production rate of the project. Based on the characteristics, the program generates a plurality of projected case profiles, each of which defines characteristics of the systems for a period of the production life of the project. A controlling case is then created using information from the plurality of case profiles. In the controlling case, each of the systems is analyzed to determine in which profile the system has the greatest cost, weight, area, or other criterion. From the analysis, characteristics of the systems are generated for the project that best meet the expected production over the entire production life of the project.

Abstract: The invention relates to an airbag system for motor vehicles, integrated in an inner trim piece, in particular, in a dashboard (16), comprising an airbag (5, 5?, 5?), which is inflatable by means of a gas generator (8, 8?, 8?). The inner trim piece comprises at least one dimensionally stable support (1, 1?,k 1?) and an airbag cover (2, 2?, 2?), which opens outwards under the pressure of the airbag (5, 5?, 5?) filling with gas. The airbag cover (2, 2?, 2?) is flexible and designed to yield to the pressure of the filling airbag (5, 5?, 5?). The airbag (5, 5?, 5?) is arranged under the cover (2, 2?, 2?) in a housing (4, 4?, 4?), connected to the support (1, 1?, 1?).

Abstract: The invention relates to an airbag system for motor vehicles, integrated in an inner trim piece, in particular, in a dashboard (16), comprising an airbag (5, 5′, 5″), which is inflatable by means of a gas generator (8, 8′, 8″). The inner trim piece comprises at least one dimensionally stable support (1, 1′,k 1″) and an airbag cover (2, 2′, 2″), which opens outwards under the pressure of the airbag (5, 5′, 5″) filling with gas. The airbag cover (2, 2′, 2″) is flexible and designed to yield to the pressure of the filling airbag (5, 5′, 5″). The airbag (5, 5′, 5″) is arranged under the cover (2, 2′, 2″) in a housing (4, 4′, 4″), connected to the support (1, 1′, 1″).