Abstract: A cosmetic apparatus, comprising: (i) a first member, comprising a body, an actuator at a first end of the body, and an aperture at a second end of the body, distal from the first end; and (ii) a second member comprising a pump, a storage volume, the storage volume configured to store cosmetic, and an engaging member for fitting the second member at least partially through the aperture and at least partially within the body.

Abstract: Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). In particular, disclosed are toxic RNAi sequences in polyplexes or lipopolyplexes and methods of using said the same for killing cancer cells and treating cancer.

Abstract: In certain aspects of the disclosure, a method includes creating ink specimens. The method includes solidifying, via solvent evaporation, the ink specimens to identify Ni powders and Ti powders. The method includes debinding and pre-sintering the Ni powders and the Ti powders to form a porous NiTi skeleton. The method includes infiltrating the porous NiTi skeleton with a transient liquid. The method includes reaction sintering the NiTi of the porous NiTi skeleton and the Sn to reactively form TiNiSn. Ternary-phase thermoelectric materials formed by the method are also provided.

Abstract: Disclosure herein are an implantable cell containing device, its subcomponent scaffold, methods of making the same and their methods of use. The implantable cell containing device includes a scaffold and a cell-containing hydrogel encapsulating the scaffold. The scaffold has a tracheal-like internal system of continuous air-filled, hydrophobic micro-channels that traverse the scaffold's dimensions and a hydrophilic external surface. The implantable cell containing device, when implanted in a subject, can be used for delivering a therapeutic agent to a subject in need thereof for the treatment of various conditions and diseases.

Abstract: Butterfly valve housing for a butterfly valve having a closing element mounted rotatably in the housing, wherein receiving openings are arranged in the housing between the two flange connection discs and between the reinforcement structure, wherein the receiving openings are directed from the outer circumference in the direction of the vertical centre axis, into which the inserts can be inserted into the housing, wherein the inserts are arranged form-fittingly in the receiving openings.

Abstract: The present disclosure is directed to devices and systems for oxygenating encapsulated cells. The disclosure further relates to individual components of these devices and systems and methods of using the devices and systems to deliver a therapeutic agent to a subject in need thereof.

Abstract: Method for the preparation of moldings in a layer-by-layer process in which selectively areas of a powdered layer are melted, sintered, fused, or otherwise solidified, characterized in that as a powder for the powdered layer a thermoplastic, ground polyamide powder is used, in which the polyamide comprises laurolactam and caprolactam, preferably exclusively, and wherein the proportion of caprolactam is in the range of 40-60 mol % of the lactams used.

Abstract: A separating device for forming a standing area for livestock, in particular pigs, and for reducing emissions in pens, in particular in pig pens, comprises a base frame, a drainage element with a plurality of drainage channels which each comprise an outflow end, and shoulders, between which the plurality of drainage channels extends orthogonally to a drainage direction, a liquid-permeable endless belt with an upper run and a lower run, wherein the drainage element is arranged on the base frame such that a drainage direction of the plurality of drainage channels is directed in the direction of the outflow end.

Abstract: The present application relates cell replacement devices, comprising a frame cap and a frame base, where the frame cap includes a first connecting member and one or more ports that traverse a thickness of the frame cap. The frame base of the cell replacement device includes one or more walls defining an interior chamber, defining a first opening to the interior chamber on one side of the frame base, and defining a second opening to the interior chamber on another side of the frame base. The first opening of the frame base is configured to receive the frame cap, and the frame base further includes a second connecting member constructed to connect with the first connecting member. The frame base further comprises a mesh disposed adjacent the second opening.

Abstract: A separating device for forming a standing area for livestock, in particular pigs, and for reducing emissions in pens, in particular in pig pens, comprises a base frame, a drainage element with a plurality of drainage channels which each comprise an outflow end, and shoulders, between which the plurality of drainage channels extends orthogonally to a drainage direction, a liquid-permeable endless belt with an upper run and a lower run, wherein the drainage element is arranged on the base frame such that a drainage direction of the plurality of drainage channels is directed in the direction of the outflow end.

Abstract: A separating device for forming a standing area for livestock, in particular pigs, and for reducing emissions in pens, in particular in pig pens, comprises a base frame, a drainage element with a plurality of drainage channels which each comprise an outflow end, and shoulders, between which the plurality of drainage channels extends orthogonally to a drainage direction, a liquid-permeable endless belt with an upper run and a lower run, wherein the drainage element is arranged on the base frame such that a drainage direction of the plurality of drainage channels is directed in the direction of the outflow end.

Abstract: A semiconductor device, semiconductor device assembly, and method of forming a semiconductor device assembly that includes a barrier on a pillar. The semiconductor device assembly includes a semiconductor device disposed over another semiconductor device. At least one pillar extends from one semiconductor device towards a pad on the other semiconductor device. The barrier on the exterior of the pillar may be a standoff to control a bond line between the semiconductor devices. The barrier may reduce solder bridging and may prevent reliability and electromigration issues that can result from the IMC formation between the solder and copper portions of a pillar. The barrier may help align the pillar with a pad when forming a semiconductor device assembly and may reduce misalignment due to lateral movement of the semiconductor devices. Windows or slots in the barrier may permit the expansion of solder in predetermined directions while preventing bridging in other directions.

Abstract: A semiconductor device, semiconductor device assembly, and method of forming a semiconductor device assembly that includes a barrier on a pillar. The semiconductor device assembly includes a semiconductor device disposed over another semiconductor device. At least one pillar extends from one semiconductor device towards a pad on the other semiconductor device. The barrier on the exterior of the pillar may be a standoff to control a bond line between the semiconductor devices. The barrier may reduce solder bridging and may prevent reliability and electromigration issues that can result from the IMC formation between the solder and copper portions of a pillar. The barrier may help align the pillar with a pad when forming a semiconductor device assembly and may reduce misalignment due to lateral movement of the semiconductor devices. Windows or slots in the barrier may permit the expansion of solder in predetermined directions while preventing bridging in other directions.

Abstract: The present invention relates to an electrical actuating drive (1) for devices to be adjusted mechanically, having an electrical drive motor (2) and an output-drive shaft (4) which can be adjusted over a rotation actuating range of more than 360°, comprising an integrated contactless sensor angle measurement system (6) for determining and feeding back the respective rotation position of the output-drive shaft (4). The sensor angle measurement system (6) produces an output signal which largely simulates the characteristics of a conventional multiple potentiometer system.

Abstract: An indoor ski slope (1) comprises a continuous peripheral wall (2) and a floor (3) which extends obliquely downwards relative to the peripheral wall (2). A roof (5) is arranged on the peripheral wall (2). Furthermore, a layer of snow is provided on the surface of the floor (3), as well as a cooling installation (9) for cooling the floor to a temperature which is suitable for maintaining the layer of snow. The surface of the floor (3) is at least partially curved concavely.

Abstract: The present invention relates to an electrical actuating drive (1) for devices to be adjusted mechanically, having an electrical drive motor (2) and an output-drive shaft (4) which can be adjusted over a rotation actuating range of more than 360°, comprising an integrated contactless sensor angle measurement system (6) for determining and feeding back the respective rotation position of the output-drive shaft (4). The sensor angle measurement system (6) produces an output signal which largely simulates the characteristics of a conventional multiple potentiometer system.

Abstract: An indoor ski slop (1) comprises a continuous peripheral wall (2) and a floor (3) which extends obliquely downwards relative to the peripheral wall (2). A roof (5) is arranged on the peripheral wall (2). Furthermore, a layer of snow is provided on the surface of the floor (3), as well as a cooling installation (9) for cooling the floor to a temperature which is suitable for maintaining the layer of snow. The surface of the floor (3) is at least partially curved concavely.

Abstract: Substituted N-oxidanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds according to the invention can be used as or in the case of psoriasis, Kaposi's sarcoma, restenosis, endometriosis, Crohn's disease, Hodgkin's disease, leukemia; arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma; eye diseases, such as diabetic retinopathy, neovascular glaucoma; renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejections and glomerulopathy; fibrotic diseases, such as cirrhosis of the liver, mesangial cell proliferative diseases, arteriosclerosis, injuries to nerve tissue, and inhibition of the reocclusion of vessels after balloon catheter treatment, in vascular prosthetics or after mechanical devices are used to keep vessels open, such as, e.g.

Abstract: Substituted cyanoanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds according to the invention can be used as or in the case of psoriasis, Kaposi's sarcoma, restenosis, such as, e.g., stent-induced restenosis, endometriosis, Crohn's disease, Hodgkin's disease, leukemia; arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma; eye diseases, such as diabetic retinopathy, neovascular glaucoma; renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejections and glomerulopathy; fibrotic diseases, such as cirrhosis of the liver, mesangial cell proliferative diseases, arteriosclerosis, injuries to nerve tissue, and inhibition of the reocclusion of vessels after balloon catheter treatment, in vascular prosthetics or after mechanical devices are used to keep vessels open, such as, e.g.

Abstract: This invention relates to 2-heteroaryl-pyrimidine derivatives of general formula I or If as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.