Patents by Inventor Alexander L. Watters

Alexander L. Watters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11312949
    Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: April 26, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
  • Publication number: 20210364522
    Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
    Type: Application
    Filed: August 4, 2021
    Publication date: November 25, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo-Hun KANG, Donald E. INGBER, Michael SUPER, Alexander L. WATTERS, Harry Scott DRISCOLL
  • Publication number: 20210277079
    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
    Type: Application
    Filed: May 12, 2021
    Publication date: September 9, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Alexander L. WATTERS, Donald E. INGBER, Mark J. CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelia MURRAY, Brendon DUSEL
  • Patent number: 11112410
    Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: September 7, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo-Hun Kang, Donald E. Ingber, Michael Super, Alexander L. Watters, Harry Scott Driscoll
  • Patent number: 11034744
    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: June 15, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
  • Publication number: 20210155677
    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.
    Type: Application
    Filed: November 10, 2020
    Publication date: May 27, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin ROTTMAN, Alexander L. WATTERS
  • Patent number: 10865235
    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: December 15, 2020
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
  • Publication number: 20200248158
    Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.
    Type: Application
    Filed: October 23, 2019
    Publication date: August 6, 2020
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael SUPER, Alexander L. WATTERS, Philip T. SNELL, Donald E. INGBER
  • Publication number: 20200239552
    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.
    Type: Application
    Filed: November 14, 2019
    Publication date: July 30, 2020
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin ROTTMAN, Alexander L. WATTERS
  • Publication number: 20200079828
    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
    Type: Application
    Filed: October 31, 2019
    Publication date: March 12, 2020
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Alexander L. WATTERS, Donald E. INGBER, Mark J. CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelia MURRAY, Brendon DUSEL
  • Patent number: 10526399
    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: January 7, 2020
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
  • Patent number: 10513546
    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: December 24, 2019
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
  • Patent number: 10501729
    Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: December 10, 2019
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
  • Publication number: 20190144567
    Abstract: This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 16, 2019
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniel Christopher LESLIE, Thomas DOYLE, Anna WATERHOUSE, Melissa RODAS, Alexander L. WATTERS, Michael SUPER, Donald E. INGBER
  • Patent number: 10245355
    Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: April 2, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Donald Ingber, Daniel C. Leslie, Michael Super, Alexander L. Watters, Anna Waterhouse
  • Publication number: 20180320157
    Abstract: Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.
    Type: Application
    Filed: May 1, 2018
    Publication date: November 8, 2018
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael SUPER, Alexander L. WATTERS, Philip T. SNELL, Donald E. INGBER
  • Patent number: 9988617
    Abstract: Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: June 5, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
  • Publication number: 20160144079
    Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.
    Type: Application
    Filed: July 10, 2014
    Publication date: May 26, 2016
    Inventors: Donald INGBER, Daniel C. LESLIE, Michael SUPER, Alexander L. WATTERS, Anna WATERHOUSE
  • Publication number: 20160090583
    Abstract: Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of for example, sepsis and rhabdomyolysis.
    Type: Application
    Filed: May 21, 2014
    Publication date: March 31, 2016
    Inventors: Michael SUPER, Alexander L. WATTERS, Philip T. SNELL, Donald E. INGBER
  • Publication number: 20150173883
    Abstract: Articles, methods of making, and uses for modifying surfaces for simultaneously providing repellency and selective binding of desired moieties are disclosed. The repellant surfaces comprise a substrate and a lubricating layer immobilized over the substrate surface having a lubricating liquid having an affinity with the substrate. The substrate and the lubricating liquid are attracted to each other together by non-covalent attractive forces. The repellent surface further includes a binding group extending over the surface of the lubricating layer and the binding group has an affinity with a target moiety. The lubricating layer and the substrate form a slippery or repellent surface configured and arranged for contact with a material that is immiscible with the lubricating liquid and the immiscible material contains the target moiety.
    Type: Application
    Filed: July 12, 2013
    Publication date: June 25, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Donald Ingber, Michael Super, Daniel C. Leslie, Tohid Didar, Alexander L. Watters, Julia Bellows Berthet, Anna Waterhouse