Patents by Inventor Alexander L. Watters
Alexander L. Watters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11939608Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.Type: GrantFiled: March 18, 2022Date of Patent: March 26, 2024Inventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
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Patent number: 11919971Abstract: This disclosure provides, e.g., methods for coupling Formation of Surface Carboxylates on PES an entity to a solid substrate. The method can comprise treating the with Exposure Time substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.Type: GrantFiled: May 16, 2017Date of Patent: March 5, 2024Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Daniel Christopher Leslie, Thomas Doyle, Anna Waterhouse, Melissa Rodas, Alexander L. Watters, Michael Super, Donald E. Ingber
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Patent number: 11795212Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: GrantFiled: November 10, 2020Date of Patent: October 24, 2023Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
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Patent number: 11718651Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: GrantFiled: May 12, 2021Date of Patent: August 8, 2023Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
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Publication number: 20220267749Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.Type: ApplicationFiled: March 18, 2022Publication date: August 25, 2022Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Michael SUPER, Alexander L. WATTERS, Philip T. SNELL, Donald E. INGBER
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Publication number: 20220195017Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. The microbe-targeting or microbe-binding molecules can comprise a microbe surface-binding domain linked to a portion of an Fc region. Further, the microbe-targeting molecules can be conjugated to substrate (e.g., a magnetic particle) to form a microbe-targeting substrate. Such microbe-targeting molecules and/or substrates and the kits comprising the same can be used in various applications, such as diagnosis and/or treatment of an infection caused by microbes. Moreover, the microbe-targeting molecules and/or substrates can be easily regenerated after use.Type: ApplicationFiled: December 30, 2021Publication date: June 23, 2022Applicant: President and Fellows of Harvard CollegeInventors: Donald E. Ingber, Michael Super, Alexander L. Watters
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Patent number: 11312949Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.Type: GrantFiled: October 23, 2019Date of Patent: April 26, 2022Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
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Publication number: 20210364522Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.Type: ApplicationFiled: August 4, 2021Publication date: November 25, 2021Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Joo-Hun KANG, Donald E. INGBER, Michael SUPER, Alexander L. WATTERS, Harry Scott DRISCOLL
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Publication number: 20210277079Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: ApplicationFiled: May 12, 2021Publication date: September 9, 2021Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. WATTERS, Donald E. INGBER, Mark J. CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelia MURRAY, Brendon DUSEL
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Patent number: 11112410Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.Type: GrantFiled: April 10, 2017Date of Patent: September 7, 2021Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Joo-Hun Kang, Donald E. Ingber, Michael Super, Alexander L. Watters, Harry Scott Driscoll
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Patent number: 11034744Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: GrantFiled: October 31, 2019Date of Patent: June 15, 2021Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
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Publication number: 20210155677Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: ApplicationFiled: November 10, 2020Publication date: May 27, 2021Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin ROTTMAN, Alexander L. WATTERS
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Patent number: 10865235Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: GrantFiled: November 14, 2019Date of Patent: December 15, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
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Publication number: 20200248158Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.Type: ApplicationFiled: October 23, 2019Publication date: August 6, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Michael SUPER, Alexander L. WATTERS, Philip T. SNELL, Donald E. INGBER
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Publication number: 20200239552Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: ApplicationFiled: November 14, 2019Publication date: July 30, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin ROTTMAN, Alexander L. WATTERS
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Publication number: 20200079828Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: ApplicationFiled: October 31, 2019Publication date: March 12, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. WATTERS, Donald E. INGBER, Mark J. CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelia MURRAY, Brendon DUSEL
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Patent number: 10526399Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: GrantFiled: January 25, 2017Date of Patent: January 7, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
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Patent number: 10513546Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: GrantFiled: December 18, 2014Date of Patent: December 24, 2019Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
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Patent number: 10501729Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.Type: GrantFiled: May 1, 2018Date of Patent: December 10, 2019Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
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Publication number: 20190144567Abstract: This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.Type: ApplicationFiled: May 16, 2017Publication date: May 16, 2019Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Daniel Christopher LESLIE, Thomas DOYLE, Anna WATERHOUSE, Melissa RODAS, Alexander L. WATTERS, Michael SUPER, Donald E. INGBER