Abstract: The present disclosure includes a filtration system having a pump in fluid communication with a pool or a spa and a hybrid filter assembly including: one or more membrane filters, a prefilter in fluid communication with the one or more membrane filters, a valve, and a controller. The valve includes a first port in fluid communication with the one or more membrane filters, a second port in fluid communication with the prefilter, a third port in fluid communication with the pump, a fourth port in fluid communication with the pool or the spa, and a fifth port in fluid communication with a waste system. The hybrid filter assembly also includes a chemical cleaning system with a container designed to retain a chemical cleaning agent, where the container is in fluid communication with the hybrid filter assembly. The controller is in communication with the valve to perform several functions described herein.

Abstract: A multi-filter modular pack assembly for filtering a fluid from an aquatic application is provided. The multi-filter modular pack assembly includes a vessel including a housing, a plurality of filtration modules contained within the housing designed to filter the fluid from the aquatic application and produce a filtered fluid, an inlet port designed to direct the fluid from the aquatic application into the vessel, and an outlet port designed to direct the filtered fluid out of the vessel to the aquatic application, and one or more valves designed to control a flow of fluid. The one or more valves are in fluid communication with at least one of the inlet port, the outlet port, or the plurality of filtration modules.

Abstract: A lid for a skimmer for an aquatic environment is disclosed. The lid includes a top member having a top side and a bottom side. The lid also includes a main body extending downwardly from the bottom side of the top member and a vision system disposed on the bottom side of the top member. The vision system is designed to detect objects in a filter of the skimmer. The lid includes a controller designed to output a signal to alert that the filter needs to be emptied.

Abstract: Deep Convolutional Neural Networks (CNNs) can be used to identify a non-linear control valve event in a control loop of a chemical process. Identifying the non-linear control valve event can be based on a predetermined feature of a red, green and blue (RGB) image, where the RGB image is obtained by merging respective matrices assembled from continuous wavelet transform coefficients derived from chemical plant operation controller signals. Once the non-linear control valve event is identified in a control loop, controller settings can be modified to minimize the non-linear control valve event and/or a root cause investigation can be conducted to address the issue.

Abstract: An advantageous isolated morphic form of trilaciclib which is 2?-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one in the form of a free base.

Abstract: A plant based cheese is made of a protein such as cashew protein, liquid low saturated fat vegetable oil, cultures and modified food starches. The ingredients are combined to form an emulsion, which is heated and held at a selected temperature for a selected time such that starches gelatinize. Shear is applied to the emulsion. The emulsion is liquid at the selected temperature but when cooled, the emulsion becomes solid. In its solid state, when it is heated, the product melts, closely resembling certain dairy cheeses. The liquid oil has relatively low saturated fat.

Abstract: An end effector device for use with a scanning electron microscope includes a body defining a shaft extending along a longitudinal axis between a distal end and a proximal end. The proximal end features a bulbous portion, while the distal end has a first aperture aligned with the longitudinal axis, designed to receive a stem of a scanning electron microscope sample holder. The proximal end has a second aperture aligned with the longitudinal axis to receive an extension rod. The body also has a clip aperture, defined as a blind bore extending partially into the shaft, substantially orthogonal to the longitudinal axis. A clip is positioned within the clip aperture, held in place with a pin traversing through a pin aperture, allowing the clip to transition between a stem-engaging and a release configuration. A spring is positioned between the clip and the body to bias the clip to the stem-engaging configuration. The body is 3D printed, starting at the planar proximal end defined by the bulbous portion.

Abstract: A data encoding method includes identifying within an image at least a foveal zone and a peripheral zone, the foveal zone of the image being estimated to coincide with the fovea of a user's eye when viewed by the user, encoding for transmission the different zones of the image at different qualities, the encoding quality for the foveal zone being higher than for the peripheral zone, and transmitting the encoded image to a remote viewing device; meanwhile, a data decoding method includes receiving an encoded image, different portions of the encoded image having been encoded at different qualities according to whether they are in at least a foveal zone and a peripheral zone, the foveal zone of the image being estimated to coincide with the fovea of a user's eye when viewed by the user, and the encoding quality for the foveal zone being higher than for the peripheral zone, decoding the portions of the image according to a respective decoding scheme corresponding to the respective encoding of each portion of the

Abstract: Dosages and regimens based on the discovery of unexpectedly high and sustained exposure of INX-315 in humans in need thereof which results in increased efficacy per dose and minimizes adverse events during treatment, including by minimizing the ratio of Cmax to Cmin, resulting in a decrease in an initial drug spike after administration.

Abstract: An advantageous isolated morphic form of trilaciclib which is 2?-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

Abstract: An advantageous isolated morphic form of trilaciclib which is 2?-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

Abstract: An advantageous isolated morphic form of trilaciclib which is 2?-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

Abstract: A fuel composition comprising as an additive the reaction product of a polycarboxylic acid having no more than 5 carbon atoms per carboxylic acid group, or an anhydride thereof and an alcohol having at least 5 carbon atoms.

Abstract: Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.

Abstract: The present invention relates to the prevention and/or treatment of retinal disorders, such as cone dystrophies, cone-rod dystrophies, in particular Achromatopsia.

Abstract: This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of for advantageous therapeutic pharmaceutical efficacy and dosage form stability.

Abstract: The invention relates to the use of gene therapy vectors to improve vision by introducing into healthy rod photoreceptor cells of a patient suffering from cone photoreceptor dysfunction and/or degeneration a nucleic acid encoding a gene product that is light-sensitive and/or that modulates endogenous light-sensitive signalling in a photoreceptor cell, such that the range of light intensities to which the rod photoreceptor responds is extended and/or the speed at which the rod photoreceptor responds to light is increased

Abstract: An advantageous isolated morphic form of trilaciclib which is 2?-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

Abstract: An advantageous isolated morphic form of trilaciclib which is 2?-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

Abstract: An advantageous isolated morphic form of trilaciclib which is 2?-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.