Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: The present invention relates to the prevention and/or treatment of retinal disorders, such as cone dystrophies, cone-rod dystrophies, in particular Achromatopsia.

Abstract: A system includes a ring oscillator including an odd number of inverters arranged in a ring. The system also includes a time to digital converter including an odd number of flops, where each of the flops is coupled to an output of a different inverter. The system includes a level shifter coupled to the inverters and to the flops. The system also includes a Gray counter coupled to at least one of the flops. The system includes a decoder coupled to the time to digital converter. The system also includes a phase frequency detector coupled to the decoder.

Abstract: Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia secondary to or associated with non-dialysis dependent chronic kidney disease anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.

Abstract: A method includes displaying a home ER environment characterized by home ER world coordinates, including one or more diorama-view representation of one or more respective ER environments. Each diorama-view representation includes ER objects arranged in a spatial relationship according to corresponding ER world coordinates. In some implementations, in response to detecting an input directed to a first diorama-view representation, the method includes transforming the home ER environment. Transforming the home ER environment includes transforming the spatial relationship between a subset of the ER objects as a function of the home ER world coordinates and corresponding ER world coordinates.

Abstract: The disclosure provides a device and methods for delivering a multi-component fluid. In some cases, the device may comprise a tube, a mixer, and a nozzle. The tube may comprise a plurality of lumens carrying components of a multi-component fluid separately, and a dispersant. The mixer may receive and mix the separate multiple components to form the multi-component fluid. The dispersant may travel in a dispersant passageway disposed within the mixer. The multi-component fluid and the dispersant may be delivered through a nozzle outlet. In some cases, the dispersant and/or nozzle aerosolize the delivered multi-component fluid.

Abstract: A tangential on-board injector (TOBI), comprising: a body defining an annular passageway to receive cooling air, the TOBI defining a plurality of discharge nozzles; a rotating component mounted for rotation relative to the body about an axis of rotation; a seal extending between the body and the rotating component; a plurality of vanes circumferentially distributed about the axis of rotation and located downstream of the plurality of discharge nozzles relative to a flow of the cooling air circulating toward the seal from the plurality of discharge nozzles and upstream of the seal; and flow passages defined between the plurality of vanes, a flow passage of the flow passages extending along a passage axis, the passage axis having a tangential component at an outlet of the flow passage that is different than a tangential component of an exit flow axis of a nozzle of the plurality of discharge nozzles.

Abstract: A glitch filter system includes an input stage to receive an input signal, a first output to provide a first digital signal, and a second output to provide a second digital signal. A C-element of such system receives the first digital signal and the second digital signal and provides a third digital signal at a first logic state in response to each of the first and second digital signals having a second logic state opposite the first logic state. An output latch of such system provides an output signal at the second logic state in response to the first logic state of the third digital. The output latch also receives the first and second digital signals to maintain the first logic state of the third digital signal in response to one of the first and second digital signals changing from the second logic state to the first logic state.

Abstract: A variety of thermoplastic parts are provided with precise micro-scale features and long-range macro-scale reproducibility. By combining the advantages of rigid tool molding and soft tooling into a hybrid tooling, complex and challenging microfeatures can be created in thermoplastic parts with remarkable positional accuracy and reproducibility. The parts described herein can demonstrate orders of magnitude smaller inter-part variations and order of magnitude smaller variations with respect to a master part as compared to conventional hard and soft tooling methods. In some aspects, a plurality of thermoplastic parts having precision micro-scale features and reproducible macro-scale dimensions are provided wherein the precision micro-scale features on each part comprise at least one challenging microfeature; and wherein a mean normalized displacement of the micro-scale features is about or less when measured between the parts in the plurality of thermoplastic parts.

Abstract: Systems and methods for image tagging are described. In some embodiments, images with problematic tags are identified after applying an auto-tagger. The images with problematic tags are then sent to an object detection network. In some cases, the object detection network is trained using a training set selected to improve detection of objects associated with the problematic tags. The output of the object detection network can be merged with the output of the auto-tagger to provide a combined image tagging output. In some cases, the output of the object detection network also includes a bounding box, which can be used to crop the image around a relevant object so that the auto-tagger can be reapplied to a portion of the image.

Abstract: Systems, apparatus, and methods for thread-based scheduling within a multicore processor. Neural networking uses a network of connected nodes (aka neurons) to loosely model the neuro-biological functionality found in the human brain. Various embodiments of the present disclosure use thread dependency graphs analysis to decouple scheduling across many distributed cores. Rather than using thread dependency graphs to generate a sequential ordering for a centralized scheduler, the individual thread dependencies define a count value for each thread at compile-time. Threads and their thread dependency count are distributed to each core at run-time. Thereafter, each core can dynamically determine which threads to execute based on fulfilled thread dependencies without requiring a centralized scheduler.

Abstract: Systems, apparatus, and methods for thread-based scheduling within a multicore processor. Neural networking uses a network of connected nodes (aka neurons) to loosely model the neuro-biological functionality found in the human brain. Various embodiments of the present disclosure use thread dependency graphs analysis to decouple scheduling across many distributed cores. Rather than using thread dependency graphs to generate a sequential ordering for a centralized scheduler, the individual thread dependencies define a count value for each thread at compile-time. Threads and their thread dependency count are distributed to each core at run-time. Thereafter, each core can dynamically determine which threads to execute based on fulfilled thread dependencies without requiring a centralized scheduler.

Abstract: The embodiments described herein provide for lightning protection in aircrafts constructed with Carbon Fiber Reinforced Plastic (CFRP). In one embodiment, the apparatus includes a first Carbon Fiber Reinforced Plastic (CFRP) panel, a second CFRP panel that overlaps with the first CFRP panel in a vertical direction, and a fastener to join the first CFRP panel with the second CFRP panel, the fastener extending in the vertical direction in an area where the first CFRP panel and the second CFRP panel overlap. The apparatus further includes a plurality of electrically conductive pins in each of the first CFRP panel and the second CFRP panel, wherein the pins extend in the vertical direction proximate to the fastener to electrically connect the first CFRP panel and the second CFRP panel in the area where the first CFRP panel and the second CFRP panel overlap.

Abstract: A method includes displaying a home ER environment characterized by home ER world coordinates, including one or more diorama-view representation of one or more respective ER environments. Each diorama-view representation includes ER objects arranged in a spatial relationship according to corresponding ER world coordinates. In some implementations, in response to detecting an input directed to a first diorama-view representation, the method includes transforming the home ER environment. Transforming the home ER environment includes transforming the spatial relationship between a subset of the ER objects as a function of the home ER world coordinates and corresponding ER world coordinates.

Abstract: A gaze tracking system comprising a first camera operable to capture images of a user within an environment, a second camera, having a smaller field of view than the first camera, operable to capture images of at least one of the user's eyes, an eye identification unit operable to identify a location of at least one of the user's eyes from images captured by the first camera, a camera control unit operable to modify the position and/or orientation of the second camera in dependence upon the detected location of the at least one of the user's eyes, so as to cause the second camera to be able to capture images of at least one of the user's eyes, and a gaze direction identification unit operable to identify a gaze direction of the user from images captured by the second camera.

Abstract: A method and system for monitoring an activity. The system may include a mobile device and a control center being in at least transient electronic communication with each other, the system further including a first user profile accessed via the mobile device and a chronograph and global positioning system (GPS) tracking feature. The tracking feature is used to monitor a geographical location of a first user against passage of time and is configured to activate the first user profile when the first user is within a first predetermined distance from a location and to deactivate the first user profile when the user is within a second predetermined distance from the location. The invention extends to a method.

Abstract: A method is provided to produce a custom calendar user interface (UI) display on an electronic device display screen comprising: providing a search query to a user device; sending the search query over the network to a server system; receiving over the network by one or more user devices from a server system, information that identifies one or more code objects that match the search query; using the identified one or more identified code objects by the one or more user devices to generate one or more visual content items within a calendar user interface (UI) grid display on their device display screens.

Abstract: An electronic circuit includes an oscillator circuit, a first divider circuit, a synchronization control circuit, and a peripheral circuit. The oscillator circuit is configured to generate a base frequency clock. The first divider circuit is configured to divide the base frequency clock by a first selectable divisor to generate a divided clock. The synchronization control circuit is configured to generate a synchronization pulse that controls a change of the first selectable divisor in the first divider circuit from a first value to a second value. A pulse width of the synchronization pulse is based on the first value of the first selectable divisor. The peripheral circuit is coupled to the first divider circuit and the synchronization control circuit. The peripheral circuit includes a second divider circuit. The second divider circuit divides the divided clock by a second selectable divisor, and change the second selectable divisor responsive to the synchronization pulse.

Abstract: The present invention relates to the prevention and/or treatment of retinal disorders, such as cone dystrophies, cone-rod dystrophies, in particular Achromatopsia.

Abstract: Systems, apparatus, and methods for thread-based scheduling within a multicore processor. Neural networking uses a network of connected nodes (aka neurons) to loosely model the neuro-biological functionality found in the human brain. Various embodiments of the present disclosure use thread dependency graphs analysis to decouple scheduling across many distributed cores. Rather than using thread dependency graphs to generate a sequential ordering for a centralized scheduler, the individual thread dependencies define a count value for each thread at compile-time. Threads and their thread dependency count are distributed to each core at run-time. Thereafter, each core can dynamically determine which threads to execute based on fulfilled thread dependencies without requiring a centralized scheduler.