Patents by Inventor Alexander Smith

Alexander Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE THERAPY TO IMPROVE VISION
    Publication number: 20180030477
    Abstract: The invention relates to the use of gene therapy vectors to improve vision by introducing into healthy rod photoreceptor cells of a patient suffering from cone photoreceptor dysfunction and/or degeneration a nucleic acid encoding a gene product that is light-sensitive and/or that modulates endogenous light-sensitive signaling in a photoreceptor cell, such that the range of light intensities to which the rod photoreceptor responds is extended and/or the speed at which the rod photoreceptor responds to light is increased.
    Type: Application
    Filed: February 19, 2016
    Publication date: February 1, 2018
    Inventors: Matteo Rizzi, Robin Ali, Alexander Smith, Koji Nishiguchi
  • Optimized RPE65 Promoter and Coding Sequences
    Publication number: 20180021458
    Abstract: The present invention relates to the prevention and/or treatment of retinal dystrophyin a patient, including Leber congenital amaurosis (LCA).
    Type: Application
    Filed: February 8, 2016
    Publication date: January 25, 2018
    Inventors: Alexander Smith, Robin Ali
  • KINETIC ENERGY HARVESTING METHODS AND APPARATUS
    Publication number: 20180026513
    Abstract: A system, method, and apparatus for kinetic energy harvesting are disclosed. An example electronic device includes a processor and a battery. The electronic device also includes first and second magnet housings. Each of the first and second magnet housing contains a central magnet and a ferrous shield connected to the respective magnet housings. One of the ferrous shields is located on a first side of the first magnet housing that is opposite of a second side facing the second magnet housing. The other of the ferrous shields is located on a first side of the second magnet housing that is opposite of a second side facing the first magnet housing.
    Type: Application
    Filed: October 2, 2017
    Publication date: January 25, 2018
    Inventors: Tejas Attreya Shastry, Michael Geier, Alexander Smith
  • COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20180022741
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Application
    Filed: February 27, 2017
    Publication date: January 25, 2018
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • Passive thermal system comprising combined heat pipe and phase change material and satellites incorporating same
    Patent number: 9868551
    Abstract: A passive thermal system for use in a satellite and other aerospace applications includes a container having a heat-pipe working fluid disposed in a first chamber and a Phase Change Material (PCM) disposed in a second chamber that substantially surrounds the first chamber. The first chamber contains a wick for transporting the heat-pipe working fluid. The exterior of the first chamber has fins, etc., that extend into the PCM for heat spreading and increased interface area.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 16, 2018
    Assignee: WorldVu Satellites Limited
    Inventors: Alexander Smith, Daniel W. Field, Armen Askijian, James Grossman
  • Kinetic energy harvesting methods and apparatus
    Patent number: 9780633
    Abstract: A system, method, and apparatus for kinetic energy harvesting are disclosed. An example kinetic energy harvesting apparatus includes first and second magnet housings configured to each have a tubular shape. Each of the first and second magnet housing contains a central magnet and a ferrous shield connected to the respective magnet housings. One of the ferrous shields is located on a first side of the first magnet housing that is opposite of a second side facing the second magnet housing. The other of the ferrous shields is located on a first side of the second magnet housing that is opposite of a second side facing the first magnet housing.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: October 3, 2017
    Assignee: Stryde Technologies Inc.
    Inventors: Tejas Attreya Shastry, Michael Geier, Alexander Smith
  • Reciprocally-cycled weapon
    Patent number: 9702649
    Abstract: A reciprocally-cycled weapon delinks and fires cartridges in open-end linked ammunition belts or close-end linked ammunition belts. The weapon has first round select and first cycle fire capabilities. The bolt carrier assembly translates out of phase with the extractor assembly. The extractor assembly is configured for rearward extraction of the cartridges in close-end linked ammunition belts. The weapon works seamlessly with open-end linked and close-end linked ammunition belts.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: July 11, 2017
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Brian Hoffman, Alexander Smith, Hansen Lukman
  • RPGR-OFR15 VARIANT GENE IN THE TREATMENT OF RETINITIS PIGMENTOSA
    Publication number: 20170137480
    Abstract: The present invention relates to the treatment of ocular disease, specifically retinitis pigmentosa, by gene therapy using a modified version of the RPGR-ORF15 gene.
    Type: Application
    Filed: July 6, 2015
    Publication date: May 18, 2017
    Inventors: Robin ALI, Alexander SMITH
  • Ammunition magazine for reciprocally-cycled weapon
    Patent number: 9638483
    Abstract: An ammunition magazine is used with a reciprocally-cycled weapon for delinking and firing cartridges in close-end linked ammunition belts. The magazine includes a housing with an ammunition indexing mechanism fixed to one side of the housing. A magazine feed box is disposed above the ammunition indexing mechanism. The magazine feed box includes a movable follower having an upper and a lower position and cam pins that engage cam slots in the magazine feed box. The movable follower is configured to receive a cartridge from the weapon.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: May 2, 2017
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Brian Hoffman, Alexander Smith, Hansen Lukman
  • Motor control for externally-operated weapon
    Patent number: 9618284
    Abstract: An externally-operated weapon has a direct current servo motor that provides motive force to drive the weapon operating group at an average rate of fire. Within a single cycle, the weapon operating group is driven at rates greater than and less than the average rate of fire, while the overall rate for a single cycle is maintained at the average rate of fire. Some benefits of servo motor control include reduced power consumption, increased bolt dwell time, expansion of the weapon's battlefield role from one to many roles, and increased accuracy and shot-to-shot precision while firing from an open bolt position.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: April 11, 2017
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Brian Hoffman, Alexander Smith, Hansen Lukman
  • Passive Thermal System Comprising Combined Heat Pipe and Phase Change Material and Satellites Incorporating Same
    Publication number: 20160288928
    Abstract: A passive thermal system for use in a satellite and other aerospace applications includes a container having a heat-pipe working fluid disposed in a first chamber and a Phase Change Material (PCM) disposed in a second chamber that substantially surrounds the first chamber. The first chamber contains a wick for transporting the heat-pipe working fluid. The exterior of the first chamber has fins, etc., that extend into the PCM for heat spreading and increased interface area.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 6, 2016
    Inventors: Alexander Smith, Daniel W. Field, Armen Askijian, James Grossman
  • Compositions, formulations and methods for treating ocular diseases
    Patent number: 9440963
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 13, 2016
    Assignee: AERPIO THERAPEUTICS, INC.
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • KINETIC ENERGY HARVESTING METHODS AND APPARATUS
    Publication number: 20160248312
    Abstract: A system, method, and apparatus for kinetic energy harvesting are disclosed. An example kinetic energy harvesting apparatus includes a tubular-shaped magnet housing and an end-cap magnet configured to connect to an end of the magnet housing. The apparatus also includes a wire coil configured to be connected to the magnet housing. The apparatus further includes a central magnet configured to be located within the magnet housing and suspended via the end-cap magnet.
    Type: Application
    Filed: May 2, 2016
    Publication date: August 25, 2016
    Inventors: Tejas Attreya Shastry, Michael Geier, Alexander Smith
  • COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20160220541
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Application
    Filed: April 14, 2016
    Publication date: August 4, 2016
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20160220540
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Application
    Filed: April 14, 2016
    Publication date: August 4, 2016
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • Server side system and method for search backed calendar user interface
    Patent number: 9405810
    Abstract: A method is provided to produce a custom calendar user interface for display on an electronic device display screen comprising: receiving over a network code objects adapted for use to generate visual content items on the different user device display screens; receiving over the network from a user device, receiving a search query; identifying one or more respective received code objects that match the received search query; and sending over the network to one or more user devices, information indicating the identified matching code objects.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: August 2, 2016
    Assignee: Asana, Inc.
    Inventors: Joshua R. Smith, Anne DuBois, Cliff Chang, John Stahl, Jr., David Braginsky, Scott Alexander Smith
  • SERVER SIDE SYSTEM AND METHOD FOR SEARCH BACKED CALENDAR USER INTERFACE
    Publication number: 20160147773
    Abstract: A method is provided to produce a custom calendar user interface for display on an electronic device display screen comprising: receiving over a network code objects adapted for use to generate visual content items on the different user device display screens; receiving over the network from a user device, receiving a search query; identifying one or more respective received code objects that match the received search query; and sending over the network to one or more user devices, information indicating the identified matching code objects.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 26, 2016
    Inventors: Joshua R. Smith, Anne DuBois, Cliff Chang, John Stahl, JR., David Braginsky, Scott Alexander Smith
  • CLIENT SIDE SYSTEM AND METHOD FOR SEARCH BACKED CALENDAR USER INTERFACE
    Publication number: 20160147846
    Abstract: A method is provided to produce a custom calendar user interface (UI) display on an electronic device display screen comprising: providing a search query to a user device; sending the search query over the network to a server system; receiving over the network by one or more user devices from a server system, information that identifies one or more code objects that match the search query; using the identified one or more identified code objects by the one or more user devices to generate one or more visual content items within a calendar user interface (UI) grid display on their device display screens.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 26, 2016
    Inventors: Joshua R. Smith, Anne DuBois, Cliff Chang, John Stahl, JR., David Bragrinsky, Scott Alexander Smith
  • Kinetic energy harvesting methods and apparatus
    Patent number: 9331559
    Abstract: A system, method, and apparatus for kinetic energy harvesting are disclosed. An example kinetic energy harvesting apparatus includes a tubular-shaped magnet housing, a first end-cap magnet configured to connect to a first end of the magnet housing and a second end-cap magnet configured to connect to a second end of the magnet housing. The apparatus also includes a first wire coil configured to be connected to the magnet housing between the first end and a center of the magnet housing and a second wire coil configured to be connected to the magnet housing between the second end and the center of the magnet housing. The apparatus further includes a central magnet configured to be located within the magnet housing between the first end and the second end such that the central magnet is suspended within the magnet housing.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: May 3, 2016
    Assignee: Stryde Technologies Inc.
    Inventors: Tejas Attreya Shastry, Michael Geier, Alexander Smith
  • DEVICES AND METHODS COMPRISING NEUROMUSCULAR JUNCTIONS
    Publication number: 20160041150
    Abstract: Disclosed herein are devices comprising one or more cantilevers comprising one or more neuromuscular junctions formed by a co-culture of myotubes and motoneurons. Disclosed herein are methods of using the disclosed devices comprising one or more cantilevers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: August 7, 2015
    Publication date: February 11, 2016
    Inventors: James Hickman, Alexander Smith, Christopher Long, Kristen Pirozzi