Abstract: The present invention relates to a verification method of tablets, in particular pharmaceutical tablets. It further relates to an invisible secure marking or information which is a part of such tablet. The invention further relates to tablets suitable for such verification method, to processes for manufacturing such tablets and methods for reading the information.

Abstract: A simple and quick verification of the authenticity of a blister of elements, such as pills in the pharmaceutical industry, is provided. The pills packaged in a blister can be authenticated using mobile imaging devices such as a mobile smartphone. Generally speaking, an image of the pills and their differentiating physical characteristics in the blister is acquired and compared to at least one code which is marked on the blister itself. This code may also be encrypted. A dedicated software application on the mobile smartphone can be used to decrypt the code and compare the code to the image of the pills in the blister, to thereby evaluate authenticity of the blister and its contents.

Abstract: An authentication system reads at random or in a predetermined sequence a few, typically 3 to 5, unique product identifiers inside the package to decide whether the content is authentic or not. This cross-referencing check does not require a database connection to a central repository or database. The unique product identifiers are produced when pharmaceutical products are manufactured using embossing, for example, and a product sequence is defined by physical attributes and locations of pharmaceutical products in the packaging, the product sequence then being encrypted and used to mark the packaging of the one or more packaging levels with a coding. The coding is used to authenticate the products in the packaging downstream in the supply chain.

Abstract: A solid pharmaceutical dosage form has micro- or nanostructures impressed on the surface thereof or an interface thereof. The dosage form includes a suitable quantity and distribution of ingredients, such as one or more dyes, so as to enhance the optical contrast effect caused by the micro- or nanostructures so that the micro- or nanostructures are observable by the human eye and thereby able to provide anti-counterfeiting characteristics to the dosage form.

Abstract: A simple and quick verification of the authenticity of a blister of elements, such as pills in the pharmaceutical industry, is provided. The pills packaged in a blister can be authenticated using mobile imaging devices such as a mobile smartphone. Generally speaking, an image of the pills and their differentiating physical characteristics in the blister is acquired and compared to at least one code which is marked on the blister itself. This code may also be encrypted. A dedicated software application on the mobile smartphone can be used to decrypt the code and compare the code to the image of the pills in the blister, to thereby evaluate authenticity of the blister and its contents.

Abstract: A tablet for pharmaceutical use has on at least one part of its surface a diffractive microstructure which generates diffraction effects which can be perceived in the visible spectral range and which serve as visual safety feature. The tablet includes a plurality of individual powder particles, where the diffractive microstructures are impressed into the surface of the individual powder particles. A compression tool to produce such tablets has on one pressing surface of the compression tool micro-structures, where the microstructures have dimensions which are smaller than the dimensions of the individual crystallites of the material of the pressing surface of the compression tool. The micro-structures of the compression tool can be produced for example by ion etching or by imprinting.

Abstract: The present invention relates to a verification method of tablets, in particular pharmaceutical tablets. It further relates to an invisible secure marking or information which is a part of such tablet. The invention further relates to tablets suitable for such verification method, to processes for manufacturing such tablets and methods for reading the information.

Abstract: This inventive method assures the authenticity of drugs or other valuable substances that reside within product containers, such as syringes. The method includes initially measuring the 3D topology of the glass surface while determining the distance to the glass surface. Thereafter, a desired 3D code is written below the glass surface with a pulsed laser system. The written 3D code is readable using optical coherence topography (OCT) or parallel optical coherence tomography (pOCT) to verify the authenticity of the product container. A system uses this method with a plurality of syringes held within a tray, and a writing apparatus that moves relative to the tray to write a predetermined 3D code on each of the syringes held in the tray, during processing of the syringes along a process line while in the tray.

Abstract: The present invention relates generally to an apparatus for embossing a flexible substrate. More specifically, the present invention relates to an apparatus for embossing a curable composition coated flexible substrate with an optically variable image transferred from an embossing foil, especially belt, or sheet of an optically transparent fluoropolymer. The optically variable image is irradiated through the embossing belt, or sheet with ultraviolet light contemporaneously with the embossing so that the transferred imprint pattern cures, hardens, and retains its shape.

Abstract: The present invention discloses an isotropic optical filter comprising high-index refraction material positioned between low-index-refraction matter. At least some of the high-index refraction material has a grated structure and lateral and vertical dimensions with respect to the low-index-refraction matter such that the high-index refraction material is operative to act as a leaky waveguide for light incident on the ZOF. The grated structure comprises at least two different grating patterns. Each of the at least two grating patterns constitutes a subpixel. A plurality of subpixels is operative to diffract incident light to at least two zero-order wavelength spectra respective of the at least two grating patterns such to exhibit an isotropic color effect with respect to the rotational orientation of the isotropic optical filter. The plurality of subpixels constitute an isotropic pixel.

Abstract: The present invention relates to a method for the authentication of dosage forms such as tablets, in particular pharmaceutical tablets, by reading, i.e. detecting, code structure from the tablet, reading additional information from the package or on an information sheet, and then comparing the readings to verify authenticity. The code structure may be randomized on a plurality of tablets disposed in identifiable locations in a shared package such that the detected code structures define a unique digital signature for the package of tablets.

Abstract: Pharmaceutical tablets and dosage forms are stored in a blister pack or other type of packaging which include additional anti-counterfeiting measures that are difficult to simulate and easy to reveal with a laser pointer. The blister pack is embossed with a hidden security feature including hidden information that is revealed only when a laser beam is directed through the packaging to be deflected at the hidden security feature. The hidden security feature may also accompany other covert and/or overt security features, including multi-level hologram features embossed into the blister pack at the same time as the hidden security feature.

Abstract: The present invention discloses a method for manufacturing a zero-order diffractive filter comprising a high-index material having an upper surface and a lower surface. The high-index material is positioned between a first low-index matter and a second low-index matter; the lower surface is adjacent to said first low-index matter and the upper surface is adjacent to the second low-index matter. Moreover, the high-index material has an index of refraction that is higher than the index of refraction of both said first low-index matter and said second low-index matter. The method comprises at least the following procedure: selectively providing, by employing at least one wet-coating technique, at least one of the following at least partially: the high-index material onto said first low-index matter.

Abstract: A sensor which reacts on influences from an environment. The sensor includes a zero-order diffractive color filter. The zero-order diffractive color filter includes a high-index waveguide layer, a zero-order diffractive grating structure and a layer of an reactive material, wherein the reactive material is in contact with the environment and wherein the reactive material changes its optical properties upon interaction with the environment. The reactive material is embedded in the waveguide layer and/or the reactive material is located at a maximum distance d from the waveguide layer. The distancing is effected by an intra layer having a low index of refraction.

Abstract: This inventive method assures the authenticity of drugs or other valuable substances that reside within product containers, such as syringes. The method includes initially measuring the 3D topology of the glass surface while determining the distance to the glass surface. Thereafter, a desired 3D code is written below the glass surface with a pulsed laser system. The written 3D code is readable using optical coherence topography (OCT) or parallel optical coherence tomography (pOCT) to verify the authenticity of the product container. A system uses this method with a plurality of syringes held within a tray, and a writing apparatus that moves relative to the tray to write a predetermined 3D code on each of the syringes held in the tray, during processing of the syringes along a process line while in the tray.

Abstract: A solid pharmaceutical dosage form [19] has micro- or nanostructures [10a, 10b, 10c, 10d] impressed on the surface thereof or an interface thereof. The dosage form [19] includes a suitable quantity and distribution of ingredients, such as one or more dyes, so as to enhance the optical contrast effect, C, caused by the micro- or nanostructures so that the micro- or nanostructures are observable by the human eye and thereby able to provide anti-counterfeiting characteristics to the dosage form.

Abstract: A security device including a zero order diffractive microstructure buried within a substrate. One or more optical structures, such as microlenses, may be formed on a surface of the substrate. The optical structures modify the optical characteristics of the zero order diffractive microstructure. Various alternatives or additional optical structures and methods of producing the security device are described in additional embodiments.

Abstract: An assay assembly that includes an assay bar having a plurality flow cells is disclosed. Each of the flow cells includes an inlet, an outlet, and an inside surface defining an inner volume. The outlet includes a valve that is configured to retain liquid within the inner volume of the flow cell. Each assay bar is configured to be reversibly stacked upon another assay bar, such that the flow cells of the stacked assay bars are in fluid communication with each other. This way, the outlet of a first flow cell of a first assay bar is in fluid communication with the inlet of a second flow cell of a second assay bar. The assay assembly may include a multitude of assay bars to form a composite assay assembly, with the flow cells of the stacked assay bars being in fluid communication with each other.

Abstract: The present invention relates to a verification method for tracking and tracing tablets, particularly pharmaceutical tablets. It further relates to a visible secure marking or information that is a part of such tablet (10). The invention further relates to tablets suitable for such verification method, processes for manufacturing such tablets, and methods for reading the information.

Abstract: A method of tracking and tracing tablets, in particular pharmaceutical tablets, includes reading, i.e. detecting, code structure from the tablet, reading additional information from the package on an information sheet, and then comparing the readings to verify authenticity. The code structure may be two-dimensional or three-dimensional. The detected code may further be compared with information stored in a database.